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This meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was a risk factor for cutaneous melanoma in population-based subgroup.
We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR (zeige AHR Proteine), CYP1A1 (zeige CYP1A1 Proteine), and XRCC1 polymorphisms had lower birth size.
Study suggested that RAD51 (zeige RAD51 Proteine), XRCC1, and XRCC3 (zeige XRCC3 Proteine) polymorphisms may be predictive factors for radiation-induced acute toxicity in rectal cancer patients treated with preoperative combined therapy.
Allelic variants in ERCC1 and ERCC2 are not associated with an increased risk of developing pre-senile cataract. The presence of Gln/Gln in XRCC1 in the pre-senile cataract group with regard to the group without cataract is associated with a major risk of developing pre-senile cataract.
XRCC1 Arg399Gln Gln/Gln genotype, Gln allele, and homozygote variants of XRCC3 Thr241Met polymorphism may be a risk factor for predisposition of Oral Squamous Cell Carcinoma in Turkish. In addition, XRCC3 Thr241Met genotype could be associated with tumor size and level of daily smoking.
XRCC1 polymorphism is associated with colorectal cancer.
We demonstrated an association between six previously published single nucleotide polymorphisms (rs15869 [ BRCA2 (zeige BRCA2 Proteine)], rs1805389 [ LIG4 (zeige LIG4 Proteine)], rs8079544 [ TP53 (zeige TP53 Proteine)], rs25489 [ XRCC1], rs1673041 [ POLD1 (zeige POLD1 Proteine)], and rs11615 [ ERCC1 (zeige ERCC1 Proteine)]) and subsequent CNS tumors in survivors of childhood cancer treated by radiation therapy.
our study provided preliminary evidence that the ERCC2 (zeige ERCC2 Proteine) rs50872 T allele was associated with a favorable survival while the XRCC1 rs25487 A allele was associated with a worse survival outcome for advanced NSCLC patients.
Study confirmed an association between XRCC1 codon 399 genotype and the risk of acute radiation dermatitis in locally advanced nasopharyngeal carcinoma patients during intensity-modulated radiation therapy.
This study demonstrates that the presence of His allele and Gln allele in case of SULT1A1 (zeige SULT1A1 Proteine) rs9282861 and XRCC1 rs25487, respectively, involve in lung cancer prognosis in Bangladeshi population.
this review focuses on the role of the oxidized form of XRCC1 in protection against extreme oxidative stress
Repair independent of the well documented XRCC1-PNKP (zeige PNKP Proteine) interaction was studied. XRCC1 can mediate repair of strand breaks without PNKP (zeige PNKP Proteine) binding.
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (zeige PARP1 Proteine) as a therapeutic target in DNA strand break repair-defective disease
We have characterized the nuclear localization signal (NLS (zeige ALDH1A2 Proteine)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (zeige OGG1 Proteine), Neil1 (zeige NEIL1 Proteine), Mutyh (zeige MUTYH Proteine) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (zeige AFG3L2 Proteine) serves to recruit XRCC1 that in turn binds and recruits pol beta (zeige POLB Proteine), the primary DNA polymerase (zeige POLB Proteine) of the base excision repair pathway.
Lig4 (zeige LIG4 Proteine) and XRCC1 double-deficient cells switch as efficiently as Lig4 (zeige LIG4 Proteine)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (zeige LIG1 Proteine)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein