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anti-Mouse (Murine) TP53BP1 Antikörper:
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Fish Polyclonal TP53BP1 Primary Antibody für ChIP, FACS - ABIN151770
Riballo, Kühne, Rief, Doherty, Smith, Recio, Reis, Dahm, Fricke, Krempler, Parker, Jackson, Gennery, Jeggo, Löbrich: A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. in Molecular cell 2004
Show all 289 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody für ChIP, ICC - ABIN151771
Silverman, Takai, Buonomo, Eisenhaber, de Lange: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. in Genes & development 2004
Show all 70 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody für ICC, IF - ABIN152191
Murga, Jaco, Fan, Soria, Martinez-Pastor, Cuadrado, Yang, Blasco, Skoultchi, Fernandez-Capetillo: Global chromatin compaction limits the strength of the DNA damage response. in The Journal of cell biology 2007
Show all 69 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody für ICC, FACS - ABIN151311
Kang, Lee, Hoan, Sohn, Chang, You: Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage. in The Journal of biological chemistry 2009
Show all 11 Pubmed References
Human Monoclonal TP53BP1 Primary Antibody für BI, WB - ABIN968860
Iwabuchi, Bartel, Li, Marraccino, Fields: Two cellular proteins that bind to wild-type but not mutant p53. in Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 3 Pubmed References
Human Monoclonal TP53BP1 Primary Antibody für BI, WB - ABIN968861
Iwabuchi, Li, Massa, Trask, Date, Fields: Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. in The Journal of biological chemistry 1998
Show all 3 Pubmed References
Human Monoclonal TP53BP1 Primary Antibody für FACS, IHC - ABIN1724820
Nakada, Yonamine, Matsuo: RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1. in Cancer research 2012
Show all 2 Pubmed References
Human Monoclonal TP53BP1 Primary Antibody für FACS, IHC - ABIN1724821
Mok, Henderson: The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci. in The international journal of biochemistry & cell biology 2012
Show all 2 Pubmed References
Human Polyclonal TP53BP1 Primary Antibody für IF (p), IHC (p) - ABIN682993
Cai, Cao, Zhang, Xue, Zhang, Zhou, Zhou, Sun, Fu: Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. in The Journal of biological chemistry 2015
Human Polyclonal TP53BP1 Primary Antibody für ICC, IF - ABIN4252095
Kondratova, Watanabe, Marotta, Cannon, Segall, Serre, Tanaka: Replication fork integrity and intra-S phase checkpoint suppress gene amplification. in Nucleic acids research 2015
this study shows that 53BP1 is required for three-dimensional organization of the immunoglobulin heavy chain locus and provides a plausible explanation for the link with 53BP1 enforcement of deletional immunoglobulin class switch recombination
Genomic instability can be rescued by the deletion of Trp53bp1, which encodes the DNA damage response factor 53BP1, and mice expressing RING-less BRCA1 (zeige BRCA1 Antikörper) do not show an increased susceptibility to tumors in the absence of 53BP1.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (zeige RAD51 Antikörper) and 53BP1 were recruited to these sites. H2AX (zeige H2AFX Antikörper) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (zeige H2AFX Antikörper) foci formation and DSB repair, whereas H2AX (zeige H2AFX Antikörper) was barely stabilized in response to secondary DSBs, in which gammaH2AX (zeige H2AFX Antikörper) foci were small and DSBs were not efficiently repaired
Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (zeige SGMS1 Antikörper) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.
These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (zeige PRKDC Antikörper)-deficient telomeres throughout the cell cycle.
Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (zeige LMNA Antikörper) deficiency, which was not observed for heterochromatin-related proteins HP1beta (zeige CBX1 Antikörper) and BMI1 (zeige BMI1 Antikörper).
Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (zeige E2F1 Antikörper) target genes and allows pRb (zeige PGR Antikörper) activity to be effectively integrated with the DNA damage response.
study uncovers novel ATM (zeige ATM Antikörper)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection
Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 (zeige RIF1 Antikörper) and PTIP (zeige PAXIP1 Antikörper).
Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination
Study demonstrates a consistent resistance profile to PARPi and a unique cross-resistance profile to non-PARPi drugs in different PARPi-resistant U251 glioblastoma cells and reveals 53BP1 loss and SAMHD1 (zeige SAMHD1 Antikörper) overexpression as the primary mechanisms responsible for their resistance to PARPi and Ara (zeige FOXC1 Antikörper)-C, respectively.
number of gammaH2AX (zeige H2AFX Antikörper) foci did not significantly change following cardiac MR (median foci per cell pre-MR = 0.11, post-MR = 0.11, p = .90), but the number of 53BP1 foci significantly increased following MR
premature maturation of post-replicative chromatin restores Histone h4 lysine 20 methylation and rescues 53BP1 accumulation on replicated chromatin.
UVA-induced progerinlamin A complex formation was largely responsible for suppressing 53BP1-mediated NHEJ DSB repair activity. The present study is the first to demonstrate that UVA-induced progerin upregulation adversely affects 53BP1-mediated NHEJ DSB repair in human keratinocytes via progerinlamin A complex formation.
53BP1/RIF1 (zeige INSL6 Antikörper) has a role in limiting BRCA1/CtIP (zeige RBBP8 Antikörper)-mediated end resection to control double strand break repair pathway choice
It observed a distinct accumulation of 53BP1 protein to UV-induced DNA lesions: in R273C mutants, 53BP1 appeared transiently at DNA lesions, during 10-30 min after irradiation; the mutation R282W was responsible for accumulation of 53BP1 immediately after UVA-damage; and in L194F mutants, the first appearance of 53BP1 protein at the lesions occurred during 60-70 min.
A reciprocal regulation between 53BP1 and APC (zeige APC Antikörper)/C that is required for response to mitotic stress.
The authors identified 53BP1 and USP28 (zeige USP28 Antikörper) as essential components acting upstream of p53 (zeige TP53 Antikörper), evoking p21 (zeige CDKN1A Antikörper)-dependent cell cycle arrest in response not only to centrosome loss, but also to other distinct defects causing prolonged mitosis.
BRCA1 promotes PP4C (zeige PPP4C Antikörper)-dependent 53BP1 dephosphorylation and RIF1 (zeige INSL6 Antikörper) release, directing repair toward homologous recombination.
Co-localization of gammaH2AX (zeige H2AFX Antikörper) and 53BP1 indicates promotion of (in)effective nonhomologous end-joining repair mechanisms at sites of DSB. Moreover, gammaH2AX (zeige H2AFX Antikörper)/53BP1 foci distribution presumably reveals a non-random spatial organization of the genome in MDS (zeige PAFAH1B1 Antikörper) and AML (zeige RUNX1 Antikörper).
May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).
tumor protein p53 binding protein 1
, tumor protein p53 binding protein, 1
, tumor suppressor p53-binding protein 1-like
, tumor protein p53 binding protein 1 (predicted), 5 prime
, tumor protein p53 binding protein 1 (predicted), 3 prime
, murine p53-binding protein
, p53-binding protein 1
, transformation related protein 53 binding-protein 1
, tumor suppressor p53-binding protein 1
, tumor protein 53-binding protein, 1
, tumor protein p53-binding protein, 1
, transformation related protein 53 binding protein 1