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anti-Human RAD52 Antikörper:
anti-Mouse (Murine) RAD52 Antikörper:
anti-Rat (Rattus) RAD52 Antikörper:
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Human Polyclonal RAD52 Primary Antibody für ELISA, WB - ABIN2476306
Basu, Basu, Modak: Site-directed mutagenesis of Moloney murine leukemia virus reverse transcriptase. Demonstration of lysine 103 in the nucleotide binding site. in The Journal of biological chemistry 1990
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RAD52 gene polymorphism is associated with colorectal cancer.
our study demonstrated that RAD52 polymorphisms were associated with colorectal cancer in a Chinese Han cohort
DNA-bound RAD52 is efficient at capturing ssDNA in trans.
Structure of the human DNA-repair protein RAD52 containing surface mutations has been reported.
Rad52 inverse strand exchange plays an important role in RNA-templated double strand break repair in vivo.
The mitotic DNA synthesis is RAD52 dependent, and RAD52 is required for the timely recruitment of MUS81 (zeige MUS81 Antikörper) and POLD3 (zeige POLD3 Antikörper) to common fragile sites in early mitosis.
Human RAD52-null cells retain a significant level of single-strand annealing (SSA (zeige TRIM21 Antikörper)) activity demonstrating perforce that additional SSA (zeige TRIM21 Antikörper)-like activities must exist in human cells. Moreover, the SSA (zeige TRIM21 Antikörper) activity associated with RAD52 is involved in, but not absolutely required for, most homology-directed repair (HDR (zeige GATA3 Antikörper)) subpathways. Specifically, a deficiency in RAD52 impaired the repair of DNA DSBs.
Data suggest RAD52 binds tightly to RPA (zeige RPA1 Antikörper)/ssDNA complex in presynaptic complex and inhibits RPA (zeige RPA1 Antikörper) turnover; during presynaptic complex assembly, most of RPA (zeige RPA1 Antikörper) and RAD52 is displaced from ssDNA, but some RAD52/RPA (zeige RPA1 Antikörper)/ssDNA complexes persist as interspersed clusters surrounded by RAD51 (zeige RAD51 Antikörper) filaments. (RAD52 = Rad52 DNA repair/recombination protein (zeige RAD50 Antikörper); RPA (zeige RPA1 Antikörper) = replication protein A (zeige GPR153 Antikörper); ssDNA = single-stranded DNA; RAD51 (zeige RAD51 Antikörper) = Rad51 (zeige RAD51 Antikörper) recombinase (zeige RAG1 Antikörper))
The C-terminal region of yRad52, but not of hRAD52, is involved in ssDNA annealing. This suggests that the second DNA binding site is required for the efficient ssDNA annealing by yRad52. We propose an updated model of Rad52-mediated ssDNA annealing.
Study discovered two cis (zeige CISH Antikörper)-expression quantitative trait loci SNPs in the RAD52 gene that are associated with its expression and are also associated with lung squamous cell carcinomas (LUSC) risk.
Results demonstrate that Rad52 depletion increased cell death, decreased myeloid cell frequency, and augmented the activity of CD8 (zeige CD8A Antikörper)+ T cells and NK effectors that ultimately led to reduced tumor growth. These data provide support for the notion of RAD52 as a potential oncogene (zeige RAB1A Antikörper), implicating a major role for the combined processes of recombinational repair and host immunity in determining risk for Squamous Cell.
In cancer-prone, heterozygous APC (zeige APC Antikörper) mutant mice, homozygous deletion of the Rad52 gene suppressed tumor growth and prolonged lifespan.
Rad54 (zeige RAD54L Antikörper) has a key function in maintaining genomic integrity of the developing germ cells.
Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm (zeige ATM Antikörper)-deficient mice.
RAD52 modulates the outcome of recombinant HIV-l vector infection by markedly reducing the efficiency of productive integration events
Inactivation of RAD52 aggravates X-ray and mitomycine C sensitivity in mice with RAD54 (zeige RAD54L Antikörper) gene degect.
Cells expressing Rad52 splice variants favor sister chromatid repair.
Results indicate that RAD52 cooperates with OGG1 (zeige OGG1 Antikörper) to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress.
The complete cDNA sequences of the pig RAD51 (zeige RAD51 Antikörper), RAD52, and RAD54 (zeige RAD54L Antikörper) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
Rad51 (zeige RAD51 Antikörper) and Rad52 physically interact with CENP-ACaCse4 in vivo.
Rad52 prevents chromosome loss and truncation.
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair.
DNA repair protein RAD52 homolog
, recombination protein RAD52
, rhabdomyosarcoma antigen MU-RMS-40.23
, RAD52 homolog (S. cerevisiae)
, RAD52 homolog isoform alpha
, DNA repair protein RAD52
, DNA repair protein RAD52 homolog-like
, RAD52 homolog
, potential dsDNA break repair annealing factor
, DNA repair and recombination protein, putative
, RAD52 protein