Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
The changes in MGMT expression reflect the impairment of DNA repair, which probably serves as a stage in the development and progression of endometriosis.
MGMT methylation was observed in 37% of cases with primary CNS diffuse large B-cell lymphoma
Methylguanine methyltransferase (MGMT) is a key gene that encodes for a protein that repairs DNA.
Study provides evidence that low-expression of TET1 (zeige TET1 Proteine) in oral squamous cell carcinoma (OSCC) stem cells may stimulate MGMT promoter methylation, while inhibiting MGMT mRNA expression, which ultimately strengthens the sensitivity of OSCC stem cells in regards to chemotherapeutics.
High MGMT expression is associated with glioblastoma multiforme resistance to temozolomide
This study shows that when cell death and cell cycle arrest pathways are inhibited, p53 (zeige TP53 Proteine) can still mediate MGMT-dependent repair, to promote cell survival upon DNA damage.
Data suggest that MGMT promoter methylation could be an important factor in determining which melanoma patients should receive melphalan regional chemotherapy.
MGMT promoter methylation may be correlated with esophageal cancer carcinogenesis and could be associated with age, lymph node status, and clinical stage.
DNA promoter hypermethylation and gene expression of MGMT may associate with recursive mutagenesis and is a promising biomarker for OSCC prediction.
Results show that folate concentrations >45.3 nmol/L increased the risk of methylation in specific CpG sites of MGMT.
Snell, GHKRO, and PAPPA (zeige PAPPA Proteine)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1 (zeige NDRG1 Proteine)).
This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (zeige C16orf35 Proteine), as a key node in determining a carcinogenic threshold.
Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.
Loss of MGMT expression and high Ezrin (zeige EZR Proteine) protein expression leads to esophageal cancer.
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.
ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.
Roles of MGMT and MLH1 (zeige MLH1 Proteine) proteins in alkylation-induced apoptosis and mutagenesis.
Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer
GAMT (zeige GAMT Proteine) and AGAT (zeige GATM Proteine) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (zeige DMD Proteine) muscle compared to C57
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a
, O6-methylguanine-DNA methyltransferase
, methylated-DNA--protein-cysteine methyltransferase
, methylguanine-DNA methyltransferase
, O-6-alkylguanine-DNA alkyltransferase
, 0-6-methylguanine-DNA methyltransferase
, O(6)-alkylguanine-DNA alkyltransferase
, O6-alkylguanine-DNA alkyltransferase
, O6-methylguanine-DNA methyltranferase