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MGMT promoter methylation in Epstein-Barr virus-associated oral squamous cell carcinomas
Data show that O(6)-methylguanine-DNA methyltransferase (MGMT) Leu84Phe was significantly related to temozolomide (TMZ) resistance and the prognosis of patients with malignant gliomas.
MGMT promoter methylation was determined by methylation-specific polymerase chain reaction
MGMT methylation is a prognostic factor in newly diagnosed glioblastoma. In this study, we evaluated the rate of change of MGMT methylation during the clinical course of the disease, and we found a significant concordance between the first and the second MGMT methylation assessments, with MGMT methylation being stable in 75% of the cases
Findings show the cell-context dependent effects of PRIMA (zeige PRIMA1 Proteine)-1MET irrespective of p53 (zeige TP53 Proteine) status and suggest the role of O6-methylguanine-DNA methyltransferase (MGMT) as a potential molecular target of PRIMA (zeige PRIMA1 Proteine)-1MET in MGMT-positive glioblastoma stem cell (GSCs).
MGMT methylation assay, of which PSQ appeared to be the best, could improve the predictive power for Glioblastoma patients with MGMT IHC- tumors
Both blood and tumor tissue MGMT and ERCC1 (zeige ERCC1 Proteine) methylation were associated with cancer rectum.
MGMT promoter methylation may be an early biomarker for the diagnosis of breast cancer (Meta-Analysis)
Low MGMT expression assessed by immunochemistry in temozolomide-treated patients with pancreatic neuroendocrine tumors is associated with radiological objective response and increased progression-free survival.
Rs16906252C>T is associated with elevated risk for MGMT-methylated colorectal cancer.
Snell, GHKRO, and PAPPA (zeige PAPPA Proteine)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1 (zeige NDRG1 Proteine)).
This study demonstrates for the first time a non-linear dose-response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG (zeige C16orf35 Proteine), as a key node in determining a carcinogenic threshold.
Findings suggest that O6-methylguanine-DNA methyltransferase (MGMT)-mediated temozolomide resistance is associated with increased histone acetylation.
Loss of MGMT expression and high Ezrin (zeige EZR Proteine) protein expression leads to esophageal cancer.
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.
ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.
Roles of MGMT and MLH1 (zeige MLH1 Proteine) proteins in alkylation-induced apoptosis and mutagenesis.
Repression of MGMT is associated with precancerous conditions in hyperplastic mucosa adjacent to colon cancer
GAMT (zeige GAMT Proteine) and AGAT (zeige GATM Proteine) mRNA are up-regulated 5.4- and 1.9-fold respectively in adult mdx (zeige DMD Proteine) muscle compared to C57
MGMT-deficient cells would likely exhibit an increased mutational burden, but only following exposures to specific environmental mutagens such as the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a
, O6-methylguanine-DNA methyltransferase
, methylated-DNA--protein-cysteine methyltransferase
, methylguanine-DNA methyltransferase
, O-6-alkylguanine-DNA alkyltransferase
, 0-6-methylguanine-DNA methyltransferase
, O(6)-alkylguanine-DNA alkyltransferase
, O6-alkylguanine-DNA alkyltransferase
, O6-methylguanine-DNA methyltranferase