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Human MCM5 Protein expressed in Wheat germ - ABIN1310557
Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011
the decrease in recombination observed in females homozygous for mcm5(A7) is not due to a failure to create or repair meiotically induced double strand breaks (DSBs), but rather to a failure to resolve those DSBs into meiotic crossovers
different tissues may employ distinct cellular programs in responding to the depletion of MCM5
Minichromosome maintenance 5 was shown as an independent prognostic biomarker for patients with cervical cancer
MCM5 expression is associated with the malignant status and poor prognosis in cervical adenocarcinoma patients.
The RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5) promoters have the specificity and strength needed for cancer-specific expression-targeted gene therapy.
reveal the Minichromosome Maintenance Complex to be a critical and directly regulated node within the miR-183 signaling network in MYCN-amplified neuroblastoma cells. Randomly selected MCMs 3 and 5 were experimentally confirmed as direct targets of miR-183.
the incorporation of physiological levels of MCM5 into HIV-1 virions facilitates viral cDNA accumulation in newly infected cells, probably by modifying nucleic acid configuration during reverse transcription.
MCM5 is a novel gene involved in Meier-Gorlin syndrome.
Our findings support the hypothesis that MCM5 targeting may be regarded as an effective molecular therapy against anaplastic thyroid carcinoma
we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets.
The increased expression of MCM5 protein begins at the oral pre-cancerous stage and is significantly associated with the aggressive progression and poor prognosis of OSCC.
Mcm2-7 loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
Data indicate that MCM-BP binds USP7 on chromatin and can mediate an interaction between the USP7 and MCM proteins.
The results of this study demonistrated that Mcm5 shows a highly significant correlation with Alcohol use disorders-induced decreases in the volume of the left parietal supramarginal gyrus and neuropsychological measures.
MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival.
lack of MCM5 proteins expression which may explain commonly known low mitotic activity of desmoid tumour cells
MCM-5 expression was significantly associated with tumor size, presence of lymph node metastases and tumor histopathological stage. Patients with high MCM-5 expression had significantly shorter survival times.
Could use the urinary hTERT, SENP1, PPP1CA, and MCM5 mRNA to detect bladder cancer recurrence.
Results further confirm the importance of MCM5 in malignant transformation and in the pathogenesis of cervical dysplasia.
The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation.
MCM5 is part of the GINS complex.
MCM-2 and MCM-5 proteins appear to be promising as prognostic markers in patients with ovarian adenocarcinomas.
SOX10 directly activates MCM5 transcription by binding to conserved SOX10 consensus DNA sequences in the MCM5 promoter.
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.
, mini-chromosome maintenance 5
, minichromosome maintenance 5
, MCM5 minichromosome maintenance deficient 5, cell division cycle 46
, DNA replication licensing factor mcm5
, DNA replication licensing factor MCM5
, CDC46 homolog
, minichromosome maintenance deficient 5 (cell division cycle 46)
, minichromosome maintenance deficient protein 5
, CDC46 homolog A
, DNA replication licensing factor mcm5-A
, minichromosome maintenance deficient 5, cell division cycle 46
, mini chromosome maintenance deficient 5