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anti-Human ERCC2 Antikörper:
anti-Mouse (Murine) ERCC2 Antikörper:
anti-Rat (Rattus) ERCC2 Antikörper:
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Human Polyclonal ERCC2 Primary Antibody für IHC - ABIN966088
Weber, Salazar, Stewart, Thompson: ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3. in The EMBO journal 1990
Show all 9 Pubmed References
meta-analysis indicates that XRCC2 (zeige XRCC2 Antikörper) rs3218536 and ERCC2 rs13181 polymorphisms may not be associated with the risk of ovarian cancer
Results show that the response to treatment depended of the variability in genes engaged in drugs' transport ABCC2 (zeige ABCC2 Antikörper) c.-24C>T and ABCB1 (zeige ABCB1 Antikörper) p.Ser893Ala/Thr (zeige TRH Antikörper) and in DNA repair machinery ERCC2 p.Lys751Gln.
Results indicate that ERCC excision repair 2 (ERCC2) is a potential target of miR (zeige MLXIP Antikörper)-770-5p.
The allele combination of CGC from hOGG1, ITGA2 (zeige ITGA2 Antikörper) and XPD polymorphisms was significantly associated with increased odds of nasopharyngeal carcinoma.
CHD1 (zeige CHD1 Antikörper) facilitates substrate handover from XPC (zeige XPC Antikörper) to the downstream TFIIH (zeige GTF2H1 Antikörper) (transcription factor IIH).
Allelic variants in ERCC1 and ERCC2 are not associated with an increased risk of developing pre-senile cataract. The presence of Gln/Gln in XRCC1 in the pre-senile cataract group with regard to the group without cataract is associated with a major risk of developing pre-senile cataract.
our study provided preliminary evidence that the ERCC2 rs50872 T allele was associated with a favorable survival while the XRCC1 (zeige XRCC1 Antikörper) rs25487 A allele was associated with a worse survival outcome for advanced NSCLC patients.
Genetic polymorphism in ERCC2 gene is associated with response to chemotherapy in osteosarcoma.
XPD 312 single nucleotide polymorphism is associated with Non-Small-Cell Lung Cancer.
At 24 months of follow-up, patients with xeroderma pigmentosum group D protein (XPD) c.934AA genotype presented lower progression-free survival and overall survival in Kaplan-Meier estimates.
Results describe a recessive cataract caused by a mutation in the Xpd/Ercc2 gene and demonstrate the importance of the gene not only for lens fiber cell differentiation, but also for the sensitivity to ionizing radiation.
Compound TTD (zeige GTF2H5 Antikörper)/XPCS heterozygosity partially rescues metabolic phenotype associated with homozygous XPD alleles. TTD (zeige GTF2H5 Antikörper) allele dominates over XPCS allele in measures of UV-sensitivity.
premature aging associated with XPD mutation in mice
Mutations in XPD subunit of TFIIH (zeige GTF2H4 Antikörper) result in transactivation defect of PPARs in the adipose tissue and the liver.
New pathology features support the premature aging phenotype of Xpd(TTD) mutant mice and further strengthen the link between DNA damage, DNA repair and aging.
XPCS with a G602D-encoding mutation in the Xpd helicase (zeige DNA2 Antikörper) gene is the most skin cancer-prone NER (zeige NR1H2 Antikörper) model to date, and it shows an unusual NER (zeige NR1H2 Antikörper) dysfunction that is likely responsible for this susceptibility
a variety of biallelic effects on organismal phenotype which attributes to combinations of recessive Xpd alleles
results support a general model for premature aging in Xpd DNA repair deficient mice based on cellular responses to DNA damage that impair normal tissue homeostasis
ERCC2 plays role in lung cancer development in a Chinese population.
XPD expression significantly inhibited HepG2 cell proliferation, promoted HepG2 cell apoptosis, inhibited HepG2 colony formation, decreased HepG2 cells' migratory ability, and significantly lowered HepG2 cells' invasive capacity.
A novel Crb-Galla-Xpd complex and its function for proper chromosome segregation.
The multitask protein Xpd also plays an essential role in cell cycle regulation that appears to be independent of transcription or nucleotide excision repair.
The variant genotypes of XPD Lys751Gln polymorphism are associated with a higher risk of esophageal adenocarcinoma.
the regulation and expression of XPD
The zebrafish cDNA encoding xpd was isolated and examined its spatial-temporal expression during early development as well as its tissue distribution in adult zebrafish.
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, DNA excision repair protein ERCC-2
, DNA repair protein complementing XP-D cells
, TFIIH 80 kDa subunit
, TFIIH basal transcription factor complex 80 kDa subunit
, TFIIH basal transcription factor complex helicase XPD subunit
, TFIIH basal transcription factor complex helicase subunit
, TFIIH p80
, basic transcription factor 2 80 kDa subunit
, xeroderma pigmentosum complementary group D
, xeroderma pigmentosum group D-complementing protein
, excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)
, excision repair cross-complementing rodent repair deficiency, complementation group 2 protein
, excision repair cross-complementing rodent repair deficiency, complementation group 2
, excision repair cross-complementing 2
, DNA-repair protein complementing XP-D cells
, excision repair cross-complementing rodent repair deficiency, complementation group 6-like group 2
, lethal (2) SH2137
, xeroderma pigmentosum D