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Lipopolysaccharide/tumor necrosis factor-alpha (zeige TNF Proteine) treatment increased the expression of iNOS (zeige NOS2 Proteine), arginase II (zeige ARG2 Proteine), CAT-1, and CAT-2 (zeige SLC7A2 Proteine) mRNA.
Estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK. Progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation.
The rs41318021 polymorphism in the SLC7A1 gene was not associated with essential hypertension in 50-year-old subjects.
Overexpression of arginine transporter CAT-1 (zeige CRAT Proteine) is associated with accumulation of L-arginine (zeige GATM Proteine) and cell growth in human colorectal cancer tissue.
CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution.
mRNA levels for high-affini (zeige CRAT Proteine)ty CAT-1, expressed as a percentage of the wild-type value, are increased by an average 12% an (zeige DMD Proteine)d 32% in mdx and transgenic mdx:utr mice respectively.
The data demonstrates that CAT1 (zeige CRAT Proteine) significantly (but most likely not exclusively) contributes to the cellular uptake of asymmetric dimethylarginine.
In hypoxic human pulmonary microvascular endothelial cells, overexpression of CAT-1 (zeige CRAT Proteine) resulted in significantly greater L-arginine (zeige GATM Proteine) transport and NO production
In acute congestive heart failure acute renal impairment function and the modulation of metabolism and extracellular transport by the DDAH-1 (zeige DDAH1 Proteine)/CAT-1 (zeige CRAT Proteine) system determine high ADMA and SDMA levels after therapy for acute congestive heart failure.
Insulin (zeige INS Proteine) increased hCATs-L-arginine (zeige GATM Proteine) transport, maximal transport capacity, and hCAT-1 expression. Sp1 (zeige PSG1 Proteine) nuclear protein (zeige RDBP Proteine) abundance and binding to DNA, and SLC7A1 promoter activity was increased by insulin (zeige INS Proteine).
Data show that the CAT-1 (zeige CRAT Proteine) isoform plays a role in arginine uptake.
Arginine supplementation enhances small intestinal expression of SLC7A7 (zeige Slc7a7 Proteine) and SLC7A1.
Changes in the expression of b(0,+) and CAT-1 in pigs fed on amino acid supplemented versus high proteins diets.
Data show that in minipigs, increased weight and cholesterol resulting from a high-cholesterol diet are correlated with a decrease in the expression of miRNA-122, and that gene expression levels of CAT1 do not differ between groups.
Radiation hybrid mapping data indicate that the porcine SLC7A1 maps to the distal end of the short arm of pig chromosome 11
Study showed that TRPV6 (zeige TRPV6 Proteine)-expressing elements seem to be discretely organized in the brain of mouse. TRPV6 (zeige TRPV6 Proteine)-immunoreactive arcuate neurons co-express estrogen receptor alpha (zeige ESR1 Proteine) and the ion channel protein (zeige TRPC3 Proteine) expression in the mediobasal hypothalamus showed correlation with estrous cycle.
TRPV6 (zeige TRPV6 Proteine)-/- mice spontaneously developed osteoarthritis at a younger age and had more severe manifestations of OA than wild-type controls. TRPV6 (zeige TRPV6 Proteine) could regulate certain chondrocyte functions, including ECM (zeige MMRN1 Proteine) secretion, cell proliferation, and apoptosis.
A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
TRPV6 (zeige TRPV6 Proteine) plays an essential role in bone metabolism and is a critical regulator in osteoclasts differentiation and bone resorption.
CAT1 overexpression prevents obesity-induced hypertension by reducing the influence of the SNS (zeige SCN10A Proteine) on the maintenance of arterial pressure but not by buffering pressor responses to stress.
Adra2a (zeige ADRA2A Proteine) is expressed in the mesenchyme of the mouse stomach primordium at E11.5. Fzd5 and Trpv6 (zeige TRPV6 Proteine) are expressed in the epithelial layer of the stomach primordium after E11.5.
Endothelial CAT-1 overexpression can counter the ability of oxidative stress.
focus on TRPV6 (zeige TRPV6 Proteine) gene polymorphisms, the start of TRPV6 (zeige TRPV6 Proteine) translation at a non-AUG codon and the functions of TRPV6 (zeige TRPV6 Proteine) in intestinal Ca(2 (zeige CA2 Proteine)+) uptake, sperm maturation, and male fertility.
these data indicate that obesity-induced down-regulation of CAT1 expression and subsequent reduced bioavailability of nitric oxide may contribute to the development of obesity-induced hypertension.
Fibroblasts from two long-lived mice mutants (Snell dwarf (zeige POU1F1 Proteine) and PAPP-A (zeige PAPPA Proteine) knockout) expressed higher levels of CAT1 (a ATF4 (zeige ATF4 Proteine) target gene) during stress, suggesting a connection to longevity.
acts as a cationic amino acid transporter and as an ecotropic retrovirus receptor\; plays a role in the Na+-independent y+ cationic amino acid transport system
high affinity cationic amino acid transporter 1
, cationic amino acid transporter 1
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
, solute carrier family 7 member 1
, system Y+ basic amino acid transporter
, high affinity cationic amino acid transporter 1-like
, amino acid transporter, cationic 1
, ecotropic retroviral leukemia receptor homolog
, ecotropic retroviral receptor
, ecotropic retrovirus receptor homolog
, cationic amino acid transporter-1
, ecotropic retroviral leukemia receptor
, ecotropic retrovirus receptor
, Solute carrier family 7 member A1 (amino acid transporter cationic 1)
, cationic amino acid transporter, y+ system
, cationinc amino acid transporter 1
, solute carrier family 7, member 1
, calcium transport protein 1
, epithelial calcium channel 2
, osmosensitive transient receptor potential channel 3
, transient receptor potential cation channel subfamily V member 6