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there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function
In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport.
Propose regulation of placental SNAT2/LAT1 (zeige LAT Proteine) ubiquitination by mTORC1 and Nedd4-2 (zeige NEDD4L Proteine).
Decreased placental mTOR (zeige FRAP1 Proteine) activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR.
GADD34 (zeige PPP1R15A Proteine) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter (zeige SLC43A2 Proteine) SNAT2.
Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression.
SLC38A1 and SLC38A2 transcript levels are altered in placental malaria with intervillositis.
SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows.
Placental mRNA expression of system A transporter isoforms SLC38A1 and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants.
findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA
Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 in the trophectoderm and placental lineages.
GADD34 (zeige PPP1R15A Proteine) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter ATA2.
These data reveal an unexpected role for amino acid uptake and the amino acid transporter SNAT2 in regulation of pluripotent cells in culture.
The inward current of Na(+) associated with the function of SNAT2 leads to membrane depolarization and activation of voltage-sensitive Ca(2 (zeige CA2 Proteine)+) channels that mediate Ca(2 (zeige CA2 Proteine)+) influx, thereby leading to an increase in the [Ca(2 (zeige CA2 Proteine)+)](i) in enteroendocrine cells.
Insulin (zeige INS Proteine) promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. (ATA2 or SAT2 (zeige SAT2 Proteine))
crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4 (zeige SLC38A4 Proteine), Slc38a2, and Slc2a3 (zeige SLC2A3 Proteine)) may be a component of the genetic control of nutrient supply and demand during mammalian development
ATA2 on the plasma membrane is subject to polyubiquitination by Nedd4-2 (zeige NEDD4L Proteine) with consequent endocytotic sequestration and proteasomal degradation
the insulin (zeige INS Proteine)-stimulated translocation pathways for ATA2 and GLUT4 (zeige SLC2A4 Proteine) in adipocytes are distinct, involving different storage sites
SNAT2 not only regulates mTOR (zeige FRAP1 Proteine) but also regulates proteolysis through PI3K and provides a link among acidosis, insulin (zeige INS Proteine) resistance, and protein wasting in skeletal muscle cells.
Despite increased ATF4 (zeige ATF4 Proteine) binding at the C/EBP (zeige CEBPA Proteine)-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1 (By similarity).
solute carrier family 38, member 2
, Amino acid transporter A2
, sodium-coupled neutral amino acid transporter 2
, sodium-coupled neutral amino acid transporter 2-like
, amino acid transporter A2
, system A amino acid transporter 2
, system A transporter 1
, system N amino acid transporter 2
, amino acid transporter 2
, protein 40-9-1
, solute carrier family 38 member 2
, amino acid system A transporter
, amino acid transporter cationic 2
, amino acid transporter system A2
, amino acid transporter, cationic 2 (low affinity)
, Sodium-coupled neutral amino acid transporter 2
, Solute carrier family 38 member 2
, System A amino acid transporter 2
, System A transporter 1
, System N amino acid transporter 2