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TIP1;1 and TIP1;2 single or double mutants did not show significant changes in water content or water retention, and showed no sign of early senescence or growth retardation. [TIP1;2]
Morpholino knockdown of synectin in zebrafish impaired formation of the thoracic duct, due to selective defects in (zeige PROX1 Proteine)lymphangiogenic but not angiogenic sprouting.
Silencing of gipc1 in tadpoles caused lymphatic defects due to an underdevelopment and impaired migration of Prox-1 (zeige PROX1 Proteine)(+) lymphatic endothelial cells.
Results indicate that kermit 2/XGIPC is a novel component of the IGF pathway, potentially functioning through modulation of the IGF1 (zeige IGF1 Proteine) receptor.
Upregulated expression of GIPC1 is associated with glioma.
Drd3 (zeige DRD3 Proteine) palmitoylation acts as a molecular switch for Drd3 (zeige DRD3 Proteine)-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs.
The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment.
GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells.
GIPC binds LPA(1 (zeige LPAR1 Proteine)) and promotes its trafficking from APPL (zeige APPL1 Proteine)-containing signaling endosomes to EEA1 (zeige EEA1 Proteine) early endosomes and thus attenuates LPA (zeige APOA Proteine)-mediated Akt (zeige AKT1 Proteine) signaling from APPL (zeige APPL1 Proteine) endosomes.
Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer.
a novel non-Smad (zeige SMAD1 Proteine) function for endoglin (zeige ENG Proteine) and GIPC in regulating endothelial cell function during angiogenesis
The placental lectins reduced the binding of IGF-I (zeige IGF1 Proteine) to IGF-1 (zeige IGF1 Proteine) receptor in a dose-dependent manner.
Knockdown of ADRM1 (zeige Adrm1 Proteine) in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK (zeige RECK Proteine) RNA and protein
GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells
GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI (zeige MYO6 Proteine). PlexinD1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI (zeige MYO6 Proteine). GIPCs and myosin VI (zeige MYO6 Proteine) interact through two distinct interfaces and form an open-ended alternating array.
Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells.
Higher ratios of PSD-95 (zeige DLG4 Proteine)/GluN2B (zeige GRIN2B Proteine) and GAIP-interacting protein C (zeige PROC Proteine)-terminus (GIPC)/GluN2B (zeige GRIN2B Proteine) were associated with poorer learning index scores across all ages.
findings identify Gipc1 as a new interactor for Vangl2 (zeige VANGL2 Proteine); show that a myosin VI (zeige MYO6 Proteine)-Gipc1 protein complex can regulate Vangl2 (zeige VANGL2 Proteine) traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization
TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3 (zeige TGFBR3 Proteine)(-/-) mice
GIPC1-MyoGEF (zeige PLEKHG6 Proteine) complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.
Synectin is widely distributed in adult cells and tissues, and in the embryo apparent at day 4.5, peaks at day 12.5 and declines by day 18.5, and may be involved in mediation of outside-in signaling.
Synectin selectively regulates arterial branching morphogenesis.
Results define an important role for the Myo6 (zeige MYO6 Proteine)-GIPC1 motor complex in presynaptic function and in BDNF (zeige BDNF Proteine)-TrkB (zeige NTRK2 Proteine)-mediated synaptic plasticity.
a prototypical GIPC/synectin-binding receptor, revealed that deletion of its PDZ-binding motif drastically reduced GIPC/synectin and myosin VI (zeige MYO6 Proteine) recruitment to endocytic vesicles
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008
GIPC PDZ domain containing family, member 1
, GIPC PDZ domain containing family, member 3
, regulator of G-protein signalling 19 interacting protein 1
, RGS-GAIP interacting protein GIPC
, rgs-gaip interacting protein gipc
, PDZ domain-containing protein GIPC1
, PDZ domain-containing protein
, regulator of G-protein signaling 19-interacting protein 1
, developmental regulator
, GAIP C-terminus-interacting protein
, GLUT1 C-terminal binding protein
, IGF-1 receptor interacting protein 1
, RGS-GAIP-interacting protein
, RGS19-interacting protein 1
, tax interaction protein 2
, Tax interacting protein, clone 2
, regulator of G-protein signaling 19 interacting protein 1
, semaF cytoplasmic domain associated protein
, semaF cytoplasmic domain-associated protein 1
, GLUT1 C-terminal-binding protein
, RGS-GAIP interacting protein C-terminus
, RGS-GAIP interacting protein, C-terminus