Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Rat (Rattus) Antikörper:
anti-Mouse (Murine) Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Monoclonal WHSC2 Primary Antibody für ICC, FACS - ABIN1724801
Yung, Narita, Komori, Yamaguchi, Handa: Cellular dynamics of the negative transcription elongation factor NELF. in Experimental cell research 2009
Show all 2 Pubmed References
Human Monoclonal WHSC2 Primary Antibody für ICC, FACS - ABIN1724802
Kerzendorfer, Hannes, Colnaghi, Abramowicz, Carpenter, Vermeesch, ODriscoll: Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome. in Human molecular genetics 2012
Show all 2 Pubmed References
The finding that both phenotypes of arrested embryos are obtained in embryos that lack maternally provided NELF-A as well as in embryos with reduced levels of maternal NELF-E show that these phenotypes result from the reduced activity of the NELF complex.
analysis of the interactions between DSIF (zeige SUPT4H1 Antikörper) (DRB sensitivity inducing factor), NELF (negative elongation factor (zeige RDBP Antikörper)), and the Drosophila RNA polymerase II transcription elongation complex
A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B (zeige COBRA1 Antikörper). NELF-B (zeige COBRA1 Antikörper) is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E (zeige RDBP Antikörper), which is confirmed to bind RNA in vivo.
These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A and NELF-B (zeige COBRA1 Antikörper), relative to other factors in the overall gene induction sequence.
data show that NELF subunits exhibit highly specific subcellular localizations, such as in NELF bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF from cells can lead to enlarged and/or multiple nuclei
haploinsufficiency of SLBP (zeige SLBP Antikörper) and/or WHSC2 (NELF-A) contributes to several novel cellular phenotypes of WHS (zeige WHSC1 Antikörper).
NELF-C (zeige TH1L Antikörper) and NELF-D (zeige TH1L Antikörper) are highly related or identical to the protein called TH1 (zeige TH1L Antikörper), of unknown function. NELF-B (zeige COBRA1 Antikörper) and NELF-C (zeige TH1L Antikörper) or NELF-D (zeige TH1L Antikörper) are integral subunits that bring NELF-A and NELF-E (zeige RDBP Antikörper) together. [NELF-B (zeige COBRA1 Antikörper)] [NELF-C (zeige TH1L Antikörper)]
connection between the syndrome phenotype and cytogenetic abnormalities, through gradual shortening of the length of the critical region WHSCR (finally up to 165 kb), and sequencing it, at least 2 genes (WHSC1 (zeige WHSC1 Antikörper) and WHSC2) were identified.
Negative elongation factor (NELF (zeige RDBP Antikörper)) is a four subunit transcription factor. Our results point to a surprising role of NELF in the 3' end processing of histone mRNAs and suggest that NELF is a new factor that coordinates mRNA processing in transcription
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
, negative elongation factor A
, Wolf-Hirschhorn syndrome candidate 2 protein
, Wolf-Hirschhorn syndrome candidate 2
, negative elongation factor A-like
, wolf-Hirschhorn syndrome candidate 2 protein
, Wolf-Hirschhorn syndrome candidate 2 homolog