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L3mbtl1 loss-of-function was associated with significant decreases in depression and and anxiety in some of the behavioral paradigms.
generation and analysis of mice after disruption of L3MBTL1
Loss of the paternally derived allele of the imprinted L3MBTL1 gene is associated with Shwachman-Diamond syndrome.
The polycomb group protein L3MBTL1 represses a SMAD5 (zeige SMAD5 Proteine)-mediated hematopoietic transcriptional program in human pluripotent stem cells.
High expression of L3MBTL1 was associated with low grade and hormone receptor (zeige NR4A1 Proteine)-positive tumors, as well as low risk of disease recurrence and breast cancer death.
depletion of L3MBTL1 does not affect hESC self-renewal, rather it enhances differentiation toward extra-embryonic trophoblast tissues
Data suggest that the loss of L3MBTL1 contributes to the development of 20q(-) hematopoietic malignancies by inducing replicative stress, DNA damage, and genomic instability.
SET8 (zeige SETD8 Proteine)-mediated methylation of p53 (zeige TP53 Proteine) at Lys (zeige LYZ Proteine)-382 promotes the interaction between L3MBTL1 and p53 (zeige TP53 Proteine) in cells.
haploinsufficiency of L3MBTL1 contributes to some (20q-) myeloproliferative neoplasms, especially polycythemia vera (zeige IGF2BP3 Proteine), by promoting erythroid differentiation
The ability of TEL (zeige ETV6 Proteine) to repress TEL (zeige ETV6 Proteine)-responsive promoters is enhanced by the presence of H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL (zeige ETV6 Proteine) interacting domains, which are mapped to their respective SPM (zeige NPC1 Proteine)/SAM (zeige TTN Proteine) domains.
represents a previously undescribed imprinted locus, a vertebrate Polycomb (zeige CBX2 Proteine) group gene shown to be regulated by this mechanism, and has implications for the pathogenesis of myeloid malignancies associated with 20q deletions
L3MBTL may have a role in myeloid leukemia (zeige BCL11A Proteine)
This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
, L(3)mbt protein homolog
, lethal(3)malignant brain tumor-like protein 1
, l(3)mbt protein homolog
, lethal (3) malignant brain tumor l(3)
, L(3)malignant brain tumor-like protein