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In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC and better survival.
Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells.
Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE.
the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism.
The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed.
JDP2 is crucial to triggering reactivation from latency to lytic replication
3 SNPs (2 intronic: rs741846 & rs175646; & 1 in the untranslated region: rs8215) & their genotype distribution showed significant association in the Japanese & Korean but not Dutch intracranial aneurysm patients.
JDP2 expression was downregulated in pancreatic carcinoma & this correlated with metastasis & decreased post-surgery survival.
c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene
JDP2 is a cellular survival protein whose presence is necessary for normal cellular function
JDP2 acts as a repressor and could be functionally associated with HDAC3 to inhibit CHOP transcription
IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter.
A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain.
Female JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litters, and early reproductive senescence. JDP2 null females had increased levels of circulating FSH and higher expression of the Fshb subunit in the pituitary, resulting in elevated serum estrogen and higher numbers of large ovarian follicles
JDP2 acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands.
High JDP2 expression in the bone marrow contributes to metastatic spread in the lung.
results suggest a negative feedback loop between JDP2 and p53, and a direct link between JDP2 and a key oncogenic pathway
Tbx3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2.
Using transgenic mice overexpressing the AP-1 inhibitor JDP2, a central role of AP-1 in the induction of hypertrophy and apoptosis in cardiomyocytes is demonstrated.
Jdp2 transcriptionally regulates the Trp53 promoter, via an atypical AP-1 site, and Jdp2 expression negatively regulates Trp53 expression levels; a genetic mechanism for tumour formation in the context of Trp53 heterozygosity
Jdp2 plays pivotal roles in in vivo bone homeostasis and host defense by regulating osteoclast and neutrophil differentiation.
JDP2 phosphorylation by JNK results in rapid JDP2 destabilization and reduced expression levels following various cell stimuli
transcription of the gene for cyclin-A2 appears to be a direct target of JDP2 in the suppression of cell proliferation
JDP2 expression may play a critical role in liver cancer development.
JDP2, repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.JDP2 is key factor that controls the commitment of F9 cells to differentiation and shed light on AP-1 repressor functions
JDP2 protein plays a major role in promoting skeletal muscle differentiation via its involvement in cell cycle arrest and activation of the myogenic program
characterization of binding sites for stress mitogen-activated protein kinases on JDP2
Results suggest that Jun dimerization protein 2 (JDP2) may play an important role in the RANK-mediated signal transduction system, especially in osteoclast differentiation.
Fos/Jdp2/Batf locus is associated with SL3-3 mouse leukemia virus B cell lymphoma.
JDP2 inhibited both the acetylation of histone H3 in the promoter of the gene for C/EBPdelta and transcription from this promoter.
Results indicate that JDP2 is involved in the signaling pathway for senescence via epigenetic regulation of the expression of the gene for p16(Ink4a).
The authors identify Jdp2 as a key endoglin-dependent Wnt target, sufficient to establish haematopoietic fate in early mesoderm when BMP and Wnt crosstalk is disturbed.
the kinase fragment of DCLK is translocated into the nucleus upon hyperosmotic stresses and the kinase efficiently phosphorylates JDP2, a possible target in the nucleus, with the aid of histones
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Jun dimerization protein 2
, jun dimerization protein 2
, progesterone receptor co-activator
, c-Jun dimerization protein 2