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anti-Human JDP2 Antikörper:
anti-Mouse (Murine) JDP2 Antikörper:
anti-Rat (Rattus) JDP2 Antikörper:
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In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC (zeige FAM126A Antikörper) and better survival.
Preeclamptic plasma induces transcription modifications involving the AP-1 (zeige FOSB Antikörper) transcriptional regulator JDP2 in endothelial cells.
Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE.
the recruitment of multiple HDAC (zeige HDAC3 Antikörper) members to JDP2 and ATF3 (zeige ATF3 Antikörper) is part of their transcription repression mechanism.
The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed.
JDP2 is crucial to triggering reactivation from latency to lytic replication
JDP2 expression was downregulated in pancreatic carcinoma & this correlated with metastasis & decreased post-surgery survival.
c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene
JDP2 is a cellular survival protein whose presence is necessary for normal cellular function
JDP2 acts as a repressor and could be functionally associated with HDAC3 (zeige HDAC3 Antikörper) to inhibit CHOP (zeige DDIT3 Antikörper) transcription
Female JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litters, and early reproductive senescence. JDP2 null females had increased levels of circulating FSH (zeige BRD2 Antikörper) and higher expression of the Fshb (zeige FSHB Antikörper) subunit in the pituitary, resulting in elevated serum estrogen and higher numbers of large ovarian follicles
JDP2 acts as a novel transcriptional activator of the mouse Mc2r (zeige MC2R Antikörper) gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R (zeige MC2R Antikörper)-mediated steroidogenesis as well as cell signaling in adrenal glands.
High JDP2 expression in the bone marrow contributes to metastatic spread in the lung.
results suggest a negative feedback loop between JDP2 and p53 (zeige TP53 Antikörper), and a direct link between JDP2 and a key oncogenic pathway
Tbx3 (zeige TBX3 Antikörper) plays an important role in osteoclastogenesis at least in part by regulating CSF1 (zeige CSF1 Antikörper)-dependent expression of JDP2.
Using transgenic mice overexpressing the AP-1 (zeige JUN Antikörper) inhibitor JDP2, a central role of AP-1 (zeige JUN Antikörper) in the induction of hypertrophy and apoptosis in cardiomyocytes is demonstrated.
Jdp2 transcriptionally regulates the Trp53 (zeige TP53 Antikörper) promoter, via an atypical AP-1 (zeige JUN Antikörper) site, and Jdp2 expression negatively regulates Trp53 (zeige TP53 Antikörper) expression levels; a genetic mechanism for tumour formation in the context of Trp53 (zeige TP53 Antikörper) heterozygosity
Jdp2 plays pivotal roles in in vivo bone homeostasis and host defense by regulating osteoclast and neutrophil differentiation.
JDP2 phosphorylation by JNK (zeige MAPK8 Antikörper) results in rapid JDP2 destabilization and reduced expression levels following various cell stimuli
the kinase fragment of DCLK (zeige DCLK2 Antikörper) is translocated into the nucleus upon hyperosmotic stresses and the kinase efficiently phosphorylates JDP2, a possible target in the nucleus, with the aid of histones
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Jun dimerization protein 2
, jun dimerization protein 2
, progesterone receptor co-activator
, c-Jun dimerization protein 2