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Human FABP1 Protein expressed in Wheat germ - ABIN1353338
Bronsky, Karpísek, Bronská, Pechová, Jancíková, Kotolová, Stejskal, Prusa, Nevoral: Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: proteins newly identified in human breast milk. in Clinical chemistry 2006
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Our data suggests that the polymorphism in genes IL-1beta (zeige IL1B Proteine), IL-1Ra (zeige IL1RN Proteine) and FABP1 included in this study are not associated with PCOS development, but can influence important biochemical and metabolic parameters in PCOS.
On PICU day 1, interleukin-18 (zeige IL18 Proteine) predicted acute kidney injury with area under the curve=0.82, but neutrophil gelatinase-associated lipocalin (zeige LCN2 Proteine) and liver fatty acid binding protein predicted acute kidney injury with area under the curve of less than or equal to 0.69; on PICU day 2, area under the curve was higher. Interleukin-18 (zeige IL18 Proteine) and liver fatty acid binding protein on day 1 predicted prolonged acute kidney injury.
In total, 68 miRNAs potentially targeting FABP1 were selected; of these, miR (zeige MLXIP Proteine)-3941, miR (zeige MLXIP Proteine)-4517, and miR (zeige MLXIP Proteine)-4672 directly targeted the FABP1 3' untranslated region. Mimics of the three miRNAs substantially repressed FABP1 expression at translational level and led to HepG2 cell resistance to steatosis and cell injury induced by free fatty acids mixture, which rescue of FABP1 overexpression reversed.
This study demonstrated that the loss of FABP1 expression is associated with MSI (zeige MSI1 Proteine) carcinomas and that interferon gamma (zeige IFNG Proteine) stimulation plays a role in this process via its interaction with PPARgamma (zeige PPARG Proteine).
Hepatic adenomas co-occurring with fibrolamellar carcinomas show LFABP loss and are negative for PRKACA (zeige PRKACA Proteine) rearrangements, indicating they are genetically distinct lesions. These data also demonstrate that LFABP loss, which characterizes HNF1-alpha (zeige HNF1A Proteine) inactivation, is a consistent feature of fibrolamellar carcinoma, indicating HNF1-alpha (zeige HNF1A Proteine) inactivation is an important event in fibrolamellar carcinoma pathogenesis.
studies indicate that FABP1 is essential for proper lipid metabolism in differentiated enterocytes, particularly concerning fatty acids uptake and its basolateral secretion.
CDH5 (zeige CDH5 Proteine) and FABP1 expression levels were both elevated in drug-induced liver injury.
A high resolution NMR comparative molecular analysis of L-FABP T94T and L-FABP T94A in their unbound states and in the presence of representative ligands of the fatty acid and bile acid classes showed that threonine to alanine replacement did not result in strongly perturbed structural and dynamic features, although differences in oleic acid binding by the two variants were detected.
Studies show that despite overall tertiary structure similarity, the hFABP1 differs significantly from rat FABP1 in secondary structure, much larger ligand binding cavity, and affinities/specificities for some ligands. Moreover, while both mouse and hFABP1 mediate ligand induction of PPARA (zeige PPARA Proteine), they differ markedly in genes induced. hFABP1 T94A variant is associated with altered body mass index.[review]
Urinary L-FABP, NGAL (zeige LCN2 Proteine), Kim-1 (zeige HAVCR1 Proteine) and albumin (zeige ALB Proteine) levels increased during the acute phase of kidney injury and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase. These markers could detect higher risk of progression to CKD.
role of Fabp1/Scp-2 (zeige CRISP3 Proteine) in hepatic phytol metabolism
Individually ablating SCPx (zeige SCP2 Proteine) or SCP2/SCPx (zeige SCP2 Proteine) elicited concomitant upregulation of L-FABP.
Lack of a significant decrease in the flux of HDL-[(3)H]CE to biliary FC or bile acids in FABP1(-/-) mice indicates the likely compensation of its function by an as yet unidentified mechanism. Taken together, these studies demonstrate that FABP1 and SCP2 facilitate the preferential movement of HDL-CEs to bile for final elimination
data showed that Fabp1 gene ablation markedly diminished the impact of high-fat diet on brain endocannabinoid levels, especially in male mice
Studies show that despite overall tertiary structure similarity, the hFABP1 differs significantly from rat FABP1 in secondary structure, much larger ligand binding cavity, and affinities/specificities for some ligands. Moreover, while both mouse and hFABP1 mediate ligand induction of PPARA (zeige PPARA Proteine), they differ markedly in genes induced.
FABP1 knockout increased brain levels of arachidonic acid-containing endocannabinoids
L-FABP was more important in hepatic retention of bile acids, while SCP-2/SCP-x (zeige SCP2 Proteine) more broadly affected biliary bile acid and phospholipid levels.
These findings suggest that some of the phenotypic divergence between the two L-Fabp(-/-) lines may reflect unanticipated differences in genetic background, underscoring the importance of genetic background in phenotypic characterization.
Loss of L-FABP and SCP-2 (zeige CRISP3 Proteine), or both induces hepatic lipid accumulation in female mice and mimics non-alcoholic fatty liver disease.
L-FABP appears to function more in hepatic retention of bile acids as well as hepatic uptake and biliary secretion of HDL (zeige HSD11B1 Proteine)-cholesterol
combinatorial interactions between multiple regulatory factors are responsible for the gene expression of L-FABP in the liver
This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.
fatty acid-binding protein 1
, fatty acid-binding protein, liver
, liver-type fatty acid-binding protein
, 14 kDa selenium-binding protein
, fatty acid binding protein liver
, squalene- and sterol-carrier protein
, fatty acid binding protein 1, liver
, fafatty acid binding protein 1, liver
, fatty acid-binding protein
, liver fatty acid binding protein
, fatty acid binding protein 1-A, liver
, LOW QUALITY PROTEIN: fatty acid-binding protein, liver