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Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544531
Novak, Bryer, Cheng, Nguyen, Conley, Cunningham, Xue, Sisson, You, Hornberger, Koh: Macrophage-specific expression of urokinase-type plasminogen activator promotes skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 13 Pubmed References
Human PLAU Protein expressed in Human - ABIN491612
Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. in Circulation 2011
Show all 6 Pubmed References
Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544476
Zhang, Kernan, Thomas, Collins, Song, Li, Zhu, Leboeuf, Eddy: A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis. in The Journal of biological chemistry 2009
Show all 3 Pubmed References
Human PLAU Protein expressed in Insect Cells - ABIN491607
Wu, Catano, Echeverry, Torre, Haile, An, Chen, Cheng, Nicholson, Tong, Park, Yepes: Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544534
Bryer, Fantuzzi, Van Rooijen, Koh: Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2008
Human PLAU Protein expressed in Human - ABIN491028
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
Human PLAU Protein expressed in Insect Cells - ABIN491613
Kim, Tirloni, Radulovic, Lewis, Bakshi, Hill, da Silva Vaz, Logullo, Termignoni, Mulenga: Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions. in International journal for parasitology 2015
Rabbit PLAU Protein expressed in Insect Cells - ABIN2544614
Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids. in American journal of physiology. Lung cellular and molecular physiology 2013
The personalization of the patients' treatment using uPA (zeige PRAP1 Proteine)/PAI-1 (zeige SERPINE1 Proteine) tumor levels allows the reversion of the well-known poor prognostic impact of high uPA (zeige PRAP1 Proteine)/PAI-1 (zeige SERPINE1 Proteine) levels and strongly supports the use of this biomarker in clinical practice.
High Expressions of PLAU is associated with lung adenocarcinoma.
Adjuvant chemotherapy was 9% less likely to be recommended by a multidisciplinary board when using the current criteria compared with using a combination of the St. Gallen criteria and Ki67 (zeige MKI67 Proteine) and uPA (zeige PRAP1 Proteine)/PAI-1 (zeige SERPINE1 Proteine) status (P = 0.03). Taken together, our data show discordance among markers in identifying the risk of recurrence, even though each marker may prove to be independently valid.
Increased expression of uPA (zeige PRAP1 Proteine) in epidermal cells in psoriasis and in tumor cells in basal cell carcinomas suggests an important role of the uPA (zeige PRAP1 Proteine) system for aggressively proliferating and invading cells of epidermal origin.
study provides strong support in the role of L. reuteri in suppression of GC cell invasion by downregulation of pathways which is involved in extracellular matrix degradation such as uPA (zeige PRAP1 Proteine) and uPAR (zeige PLAUR Proteine)
uPA (zeige PRAP1 Proteine) protection is independent of its catalytic activity, as the amino terminal fragment of uPA (zeige PRAP1 Proteine) showed similar protection. A key enzyme for repairing oxidative DNA damage is the p53 (zeige TP53 Proteine) target hOGG1. We found a significant increase of hOGG1 after pretreatment of HACM with uPA (zeige PRAP1 Proteine). Knockdown of hOGG1 completely abrogated the protective effect of uPA (zeige PRAP1 Proteine)
We show that the tumor-suppressive actions of MEPs are mediated by PAI-1 (zeige SERPINE1 Proteine), uPA (zeige PRAP1 Proteine) and its receptor, uPAR (zeige PLAUR Proteine), and are sustained even in the presence of the CAFs (zeige TBX1 Proteine), which themselves enhance DCIS tumorigenesis via IL-6 (zeige IL6 Proteine) signaling.
Gelsolin (zeige GSN Proteine) enhances the invasive capacity of colon cancer cells via elevating intracellular superoxide (O2.-) levels by interacting with Cu/ZnSOD (zeige SOD1 Proteine), and gelsolin (zeige GSN Proteine) gene expression positively correlates with urokinase plasminogen (zeige PLG Proteine) activator (uPA (zeige PRAP1 Proteine)), an important matrix-degrading protease invovled in cancer invasion.
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (zeige IL6 Proteine) (40.2pg/mL), VEGF-A (zeige VEGFA Proteine) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (zeige PRAP1 Proteine) (248.1pg/mL), sHER-2/neu (zeige ERBB2 Proteine) (5010pg/mL) and PLGF (zeige PGF Proteine) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
Study provides evidence that the stimulation of u-PA/u-PAR (zeige PLAUR Proteine) system contributes to the activated phenotype and function of cancer-associated fibroblasts during multiple myeloma.
data presented here reveal important information about dynamics in uPA by demonstrating how various ligands can modulate uPA activity by mediating long-range conformational changes
Lymphangioleiomyomatosis is fatal lung disease associated with germline/somatic inactivating mutations in TSC2 genes. Data suggest lung lymphangioleiomyomatosis lesions and renal angiomyolipomas overexpress uPA; Tsc2-/- (or Tsc1 (zeige TSC1 Proteine)-/-) embryonic fibroblasts from knockout mice express higher uPA levels than wild-type cells. (uPA = urokinase-type plasminogen activator; Tsc (zeige SLC12A3 Proteine) = tuberous sclerosis complex protein)
The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.
an intricate link between caveolin-1 (zeige CAV1 Proteine) and Src kinase (zeige CSK Proteine)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (zeige SFTPC Proteine) expression through p53 (zeige TP53 Proteine) and uPA system-mediated cross-talk, is reported.
These studies identify uPA-dependent de-repression of vegfr1 (zeige FLT1 Proteine) and vegfr2 (zeige KDR Proteine) gene transcription through binding to HHEX/PRH (zeige HHEX Proteine) as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF (zeige VEGFA Proteine) and identifies a potential new target for control of pathologic angiogenesis.
Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.
GM-CSF (zeige CSF2 Proteine) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI.
we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (zeige PLAUR Proteine))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.
uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.
Data suggest endogenous uPA activity plays important role in oocyte maturation; these studies were conducted using in vitro oocyte maturation techniques.
Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR (zeige PLAUR Proteine)) and plasminogen activator inhibitor-1 (PAI-1 (zeige SERPINE1 Proteine)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
uPA/uPAR (zeige PLAUR Proteine) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
These data indicated that E. coli LPS (zeige IRF6 Proteine) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (zeige PLAUR Proteine) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
The plasminogen/plasminogen (zeige PLG Proteine) activator/plasmin (zeige PLG Proteine) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (zeige SERPINE2 Proteine) production, consistent with a role in extracellular matrix remodeling during follicle growth.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
urokinase-type plasminogen activator
, U-plasminogen activator
, plasminogen activator, urokinase
, plasminogen activator, urinary
, Urinary plasminogen activator, urokinase
, urokinase plasminogen activator preproprotein