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Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544531
Novak, Bryer, Cheng, Nguyen, Conley, Cunningham, Xue, Sisson, You, Hornberger, Koh: Macrophage-specific expression of urokinase-type plasminogen activator promotes skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 13 Pubmed References
Human PLAU Protein expressed in Human - ABIN491612
Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. in Circulation 2011
Show all 6 Pubmed References
Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544476
Zhang, Kernan, Thomas, Collins, Song, Li, Zhu, Leboeuf, Eddy: A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis. in The Journal of biological chemistry 2009
Show all 3 Pubmed References
Human PLAU Protein expressed in Insect Cells - ABIN491613
Kim, Tirloni, Radulovic, Lewis, Bakshi, Hill, da Silva Vaz, Logullo, Termignoni, Mulenga: Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions. in International journal for parasitology 2015
Rabbit PLAU Protein expressed in Insect Cells - ABIN2544614
Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids. in American journal of physiology. Lung cellular and molecular physiology 2013
Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544534
Bryer, Fantuzzi, Van Rooijen, Koh: Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2008
Human PLAU Protein expressed in Insect Cells - ABIN491607
Wu, Catano, Echeverry, Torre, Haile, An, Chen, Cheng, Nicholson, Tong, Park, Yepes: Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Human PLAU Protein expressed in Human - ABIN491028
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (zeige IL6 Proteine) (40.2pg/mL), VEGF-A (zeige VEGFA Proteine) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (zeige PRAP1 Proteine) (248.1pg/mL), sHER-2/neu (zeige ERBB2 Proteine) (5010pg/mL) and PLGF (zeige PGF Proteine) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
Study provides evidence that the stimulation of u-PA/u-PAR (zeige PLAUR Proteine) system contributes to the activated phenotype and function of cancer-associated fibroblasts during multiple myeloma.
OB-Rb (zeige LEPR Proteine), RhoA (zeige RHOA Proteine)/ROCK, PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine), JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) pathways and NF-kB activation are involved in leptin (zeige LEP Proteine)-induced upA (zeige PRAP1 Proteine) expression.
Results provide evidence that uPA (zeige PRAP1 Proteine) and IGF1R (zeige IGF1R Proteine) directly interact with uPAR (zeige PLAUR Proteine) enhancing malignant potential of triple-negative breast cancer.
suggest that the low endogenous levels of uPA (zeige PRAP1 Proteine) in blood are actively regulated, and that the regulatory mechanisms are disrupted in QPD in a megakaryocyte-specific manner
an intricate link between caveolin-1 (zeige CAV1 Proteine) and Src kinase (zeige CSK Proteine)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (zeige SFTPC Proteine) expression through p53 (zeige TP53 Proteine) and uPA (zeige PRAP1 Proteine) system-mediated cross-talk, is reported.
results show that the uPA (zeige PRAP1 Proteine)/uPAR (zeige PLAUR Proteine)/LRP1 (zeige LRP1 Proteine) system is a potential target for the development of therapeutic strategies to promote axonal recovery following a CNS injury
The present research concluded that aspirin suppressed prostate cancer cell invasion by reducing MMP-9 (zeige MMP9 Proteine) activity and uPA (zeige PRAP1 Proteine) expression through decreasing of IKK-beta (zeige IKBKB Proteine)-mediated NF-kappaB (zeige NFKB1 Proteine) activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.
These studies identify uPA (zeige PRAP1 Proteine)-dependent de-repression of vegfr1 (zeige FLT1 Proteine) and vegfr2 (zeige KDR Proteine) gene transcription through binding to HHEX/PRH (zeige HHEX Proteine) as a novel mechanism by which uPA (zeige PRAP1 Proteine) mediates the pro-angiogenic effects of VEGF (zeige VEGFA Proteine) and identifies a potential new target for control of pathologic angiogenesis.
We concluded that overexpression of MMP-3 (zeige MMP3 Proteine) and uPA (zeige PRAP1 Proteine), altogether with diminished expression of PAI-1 (zeige SERPINE1 Proteine) from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.
Lymphangioleiomyomatosis is fatal lung disease associated with germline/somatic inactivating mutations in TSC2 genes. Data suggest lung lymphangioleiomyomatosis lesions and renal angiomyolipomas overexpress uPA; Tsc2-/- (or Tsc1 (zeige TSC1 Proteine)-/-) embryonic fibroblasts from knockout mice express higher uPA levels than wild-type cells. (uPA = urokinase-type plasminogen activator; Tsc (zeige SLC12A3 Proteine) = tuberous sclerosis complex protein)
The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.
an intricate link between caveolin-1 (zeige CAV1 Proteine) and Src kinase (zeige CSK Proteine)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (zeige SFTPC Proteine) expression through p53 (zeige TP53 Proteine) and uPA system-mediated cross-talk, is reported.
These studies identify uPA-dependent de-repression of vegfr1 (zeige FLT1 Proteine) and vegfr2 (zeige KDR Proteine) gene transcription through binding to HHEX/PRH (zeige HHEX Proteine) as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF (zeige VEGFA Proteine) and identifies a potential new target for control of pathologic angiogenesis.
Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.
GM-CSF (zeige CSF2 Proteine) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI.
we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (zeige PLAUR Proteine))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.
Study shows that the competitive expression or activity of tPA (zeige PLAT Proteine) and/or PAI-1 (zeige SERPINE1 Proteine), rather than an altered uPA expression, determines the plasmin (zeige PLG Proteine)-mediated Abeta (zeige APP Proteine) proteolysis in brains affected by Alzheimer's disease
uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.
Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR (zeige PLAUR Proteine)) and plasminogen activator inhibitor-1 (PAI-1 (zeige SERPINE1 Proteine)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
uPA/uPAR (zeige PLAUR Proteine) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
These data indicated that E. coli LPS (zeige IRF6 Proteine) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (zeige PLAUR Proteine) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
The plasminogen/plasminogen (zeige PLG Proteine) activator/plasmin (zeige PLG Proteine) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (zeige SERPINE2 Proteine) production, consistent with a role in extracellular matrix remodeling during follicle growth.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
urokinase-type plasminogen activator
, U-plasminogen activator
, plasminogen activator, urokinase
, plasminogen activator, urinary
, Urinary plasminogen activator, urokinase
, urokinase plasminogen activator preproprotein