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Human IL 18 Protein expressed in Escherichia coli (E. coli) - ABIN413464
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 4 Pubmed References
In conclusion, liver X receptor activation inhibits IL-18 production through regulation of its transcription and maturation into an active pro-inflammatory cytokine.
MyD88 (zeige MYD88 Proteine) signaling in myeloid and dendritic cells is dispensable for IFN-gamma (zeige IFNG Proteine)-dependent control of type A F. tularensis infection.
study found that IL-18 and IL-1beta (zeige IL1B Proteine) are differentially regulated. Despite being constitutively expressed, IL-18 expression was increased and sustained after stimulation of TLRs. In contrast, IL-1beta (zeige IL1B Proteine) was induced but not sustained after chronic treatment.
the GLA (zeige GLA Proteine)-SE adjuvant operates through interaction with IL-18-producing SCMsmall ef, Cyrillic for the rapid induction of B cell expansion and differentiation, Ab secretion, and Th1 (zeige HAND1 Proteine) responses
IL-18 is essentially involved in mediating C. jejuni infection in the gnotobiotic mouse model.
These results demonstrate a central role for the AIM2 (zeige AIM2 Proteine) inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18/IL-22BP (zeige IL22RA2 Proteine)/IL-22 (zeige IL22 Proteine) and STAT3 (zeige STAT3 Proteine) pathway
Aldosterone induced IL-18 gene expression in renal tubular epithelial cells in a concentration- and time-dependent manner.
this study demonstrated the critical function of IL-18 in lipid metabolism and these findings might contribute to the progress of novel treatments for nonalcoholic fatty liver disease or nonalcoholic steatohepatitis.
Results indicated that IL-18 has roles apart from those as a proinflammatory cytokine in cardiac myocytes and suggested that IL-18 contributes to the homeostatic maintenance of mitochondrial function and gap-junction turnover in cardiac myocytes, possibly by upregulating autophagy.
IL-18-elicited NK cell perforin (zeige PRF1 Proteine) responses seem to be critical for coordinating mucosal inflammation during early infection
Study reports that the monocyte-derived cytokines IL-12 (zeige IL12A Proteine) and IL-18 act synergistically on porcine gammadelta T cells to induce IFN-gamma (zeige IFNG Proteine) production. Additional stimuli such as the mitogen ConA and IL-2 (zeige IL2 Proteine) are necessary to activate the cells for enhanced proliferation.
IL-18 concentration in saliva (zeige RAG1AP1 Proteine) was significantly increased during a 60-min acute immobilization stress in thirteen 5-month-old pigs. These results are the first evidence of a stress-related change of IL-18 in pig saliva (zeige RAG1AP1 Proteine).
endometrial expression of CASP1 (zeige CASP1 Proteine) and IL18 associated with pregnancy establishment; alteration of CASP1 (zeige CASP1 Proteine) and IL18 following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
Porcine IL-18 regulates anti-pig cellular rejection in C57BL/6 mice.
cardiac IL-18 and circulating IL-18 are involved in the pathogenesis of Fabry cardiomyopathy and left ventricular hypertrophy.
Erdr1 is negatively expressed relative to Il-18 in psoriatic lesional skin.
IL-18 (mRNA) in skeletal muscle appears to be involved in the regulation of intramuscular lipid metabolism and hypertriglyceridemia
The evidence for influenza A virus activation via an indirect, IL-18-dependent mechanism indicates that MAIT cells are protective in influenza, and also possibly in any human disease process in which inflammation and IL-18 production occur.
The development of urticaria, asthma, dermatitis, rhinitis, and eosinophilic disorders all have demonstrated correlations to increased IL-18 levels either in the tissue or systemically. IL-18 represents a novel site of immune regulation in not only allergic conditions, but also autoimmune diseases and other instances of aberrant immune functioning.
tuberculous lymphadenitis (TBL) is therefore, characterized by reduced systemic and antigen-specific concentrations of IL-1beta (zeige IL1B Proteine) and IL-18, which are reversible following anti-TB treatment, indicating that these cytokines are potential correlates of protective immunity in TBL.
Results suggest that a common functional IL18 haplotype associated with heightened proinflammatory responses confers susceptibility to stress-related depression and anxiety through effects on threat-related amygdala function, a risk pathway specific to women.
human platelets contain transcripts for the IL-18 gene. They synthesize the cytokine de novo, process and release it upon activation.
abnormal IL-18 expression is induced by genital infection and induces damage to male reproductive capacity, thereby causing male infertility
IL-18 level was found to be significantly elevated in CAD patients compared with control individuals
These results suggest that BAPC-1 is a stem/progenitor cell line and modulates the immuno-endocrine function of the anterior pituitary cells through its production of interleukin-18 and the IL-18 receptor.
Pressure overload, while enhancing IL-18 and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 antagonist IL-18BP (zeige IL18BP Proteine).
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, IL-1 gamma
, interferon gamma-inducing factor
, interferon-gamma-inducing factor
, interleukin-1 gamma
, interferon gamma inducing factor
, Interferon gamma-inducing factor
, interleukin 18
, uncharacterized protein LOC100734451