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Human ICAM-1 Protein expressed in Human Cells - ABIN2002637
Bhalla, Chugh, Mehrotra, Rathore, Tousif, Prakash Dwivedi, Prakash, Kumar Samuchiwal, Kumar, Kumar Singh, Ghanwat, Kumar, Das, Mohmmed, Malhotra, Ranganathan: Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. in Nature communications 2015
ICAM-1 (and IL-17 (zeige IL17A Proteine)) polymorphisms showed significant association with Guillian-Barre syndrome.
Airway ICAM-1 expression is markedly upregulated in CAL (zeige FBLIM1 Proteine) group, which could be crucial in rhinoviral and NTHi infections. The parenchymal ICAM-1 is affected by smoking, with no further enhancement in CAL (zeige FBLIM1 Proteine) subjects.
Atorvastatin strengthens Skp2 binding to FOXO1 or ICAM1, leading to ubiquitination and degradation. Skp2-dependent ubiquitination of major pathogenic molecules is the key mechanism for statin's protective effect on endothelial function in diabetes.
Augmented expression of endothelial adhesion molecules ICAM1/VCAM1 (zeige VCAM1 Proteine) is involved in the pathophysiology of patients with antiphospholipid syndrome.
CD133(+) CD44 (zeige CD44 Proteine)(+) CD54(+) cellular subpopulation of circulating tumor cells has a prognostic value in colorectal cancer patients with liver metastasis, especially in the survival of CRC (zeige CALR Proteine) patients with liver metastasis who did not undergo surgical treatment for metastasis.
Data suggest that the residue volume at phenylalanine (Phe) in alpha1-helix is critical for alpha(L)/beta(2) integrin (CD49a (zeige ITGA1 Proteine)/CD18 (zeige ITGB2 Proteine)) activation and binding with soluble/immobilized ICAM1 (intercellular cell adhesion molecule 1 (zeige CADM1 Proteine)).
Elevated serum uric acid concentration is significantly associated with inflammation of maternal systemic vasculature as indicated by increased TNF-alpha (zeige TNF Proteine) and ICAM-1 expression in women with preeclampsia.
Data indicate that CDH11, ICAM1 and CLDN3 (zeige CLDN3 Proteine) were overexpressed in tumors when compared to normal esophagus, normal gastric and non-dysplastic Barrett's.
High levels of serum ICAM-1 was associated with the development of multiple organ failure . High levels of VCAM-1 (zeige VCAM1 Proteine) was associated with both multiple organ failure and in-hospital mortality.
matrix stiffness-dependent ICAM-1 clustering is an important regulator of vascular inflammation
Endotoxaemia enhanced early venous thrombosis occurs in a TLR-4 (zeige TLR4 Proteine) and ICAM-1 dependent fashion, and is potentiated by neutropenia.
Neither the lack of CD36 (zeige CD36 Proteine) nor the deletion of the smac (zeige DIABLO Proteine) gene from Plasmodium chabaudi significantly impacted on acute-stage pathology or parasite sequestration. By contrast, in the absence of ICAM-1, infected animals experience less anaemia and weight loss, reduced parasite accumulation in both spleen and liver and higher peripheral blood parasitaemia during acute stage malaria.
Data show that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 (zeige ICAM2 Proteine) on B cells are essential for long-lasting cognate T follicular helper (Tfh)-B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion
in T cells, PI3Kdelta attenuates the activation of Rac1, but sustains the activation of Rap1.
PTPN22 (zeige PTPN22 Proteine) colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 (zeige ITGAL Proteine) ligand intercellular adhesion molecule-1 (ICAM-1).
These results suggest that SHP-2-via association with ICAM-1-mediates ICAM-1-induced Src activation and modulates VE-cadherin switching association with ICAM-1 or actin, thereby negatively regulating neutrophil adhesion to endothelial cells and enhancing their transendothelial migration.
Following transepithelial migration, neutrophils adhesion to ICAM-1 resulted in activation of Akt (zeige AKT1 Proteine) and beta-catenin (zeige CTNNB1 Proteine) signaling, increased epithelial-cell proliferation, and wound healing.
Blocking CD54 inhibited NK cell-mediated cytotoxicity of the GM-CSF (zeige CSF2 Proteine)-stimulated Flt3 ligand (zeige FLT3LG Proteine) conventional dendritic cells. NK cell-mediated lysis of GM-CSF (zeige CSF2 Proteine)-stimulated cDCs was, in part, a result of increased expression of CD54.
These results indicate that, whereas T cells use ICAM-1 and -2 for temporary pulmonary entrapment, neutrophils get sequestered and extravasate into inflamed lungs independent of ICAMs.
This study indicates that the ANG II (zeige AGT Proteine) effects are, in part, mediated or triggered by Gal-3 (zeige LGALS3 Proteine) together with the related intercellular signaling (ICAM-1 and IL-6 (zeige IL6 Proteine)), leading to cardiac inflammation and fibrosis.
ADMA has potent adverse effects on cell proliferation, intracellular ROS (zeige ROS1 Proteine) generation, cell permeability, levels of ICAM-1, and the tight-junction protein occludin (zeige OCLN Proteine)
Neutrophil lung infiltrations in porcine reproductive and respiratory syndrome virus infection infected animals is both ICAM-1 dependent and independent.
Chitosan oligosaccharides downregulate the expression of E-selectin (zeige SELE Proteine) and ICAM-1 by inhibiting the phosphorylation of Mitogen-Activated Protein Kinases and the activation of NF-kappaB (zeige NFKB1 Proteine) in lipopolysaccharides treated porcine iliac artery endothelial cells.
Data show that all five molecules, BNP, ICAM-1, TNF-alpha (zeige TNF Proteine), VCAM-1 (zeige VCAM1 Proteine) and IL-6 (zeige IL6 Proteine), quickly and reliably signaled adverse interactions.
Altered shear stress stimulates upregulation of endothelial VCAM-1 (zeige VCAM1 Proteine) and ICAM-1 in a BMP-4 (zeige BMP4 Proteine)- and TGF-beta1 (zeige TGFB1 Proteine)-dependent pathway.
ICAM1 and IL10 (zeige IL10 Proteine) were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (zeige JUN Proteine) may be responsible for this upregulation.
Hepatocellular glycogen (zeige GYS1 Proteine) decreases the expression of ICAM-1 mRNA of hepatic stellate cells.
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
intercellular adhesion molecule 1
, intercellular adhesion molecule 1-like
, cell surface glycoprotein P3.58
, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
, major group rhinovirus receptor
, leukocyte adhesion molecule