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Human GSTP1 Protein expressed in Wheat germ - ABIN1306100
Andrukhova, Salama, Krssak, Wiedemann, El-Housseiny, Hacker, Gildehaus, Andrukhov, Mirzaei, Kocher, Zuckermann, Aharinejad: Single-dose GSTP1 prevents infarction-induced heart failure. in Journal of cardiac failure 2014
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The aims of this study were to test the influence of XRCC1 rs25487, XRCC3 rs861539, XRCC3 rs1799794, RAD51 rs1801320 and GSTP-1 rs1695 single nucleotide polymorphisms on progression free survival (PFS) and overall survival (OS) in glioblastoma patients treated with chemoradiotherapy.
GSTP1 inactivating polymorphism is associated with acute myeloid leukemia.
the null GSTM1 and the GG genotype of GSTP1 IIe105Val were associated with improved treatment response to cisplatin-based chemotherapy (GSTT1 present/null: OR=1.328; 95% CI, 1.074-1.643) (GSTP1 GG + AG vs. AA: OR=0.596; 95% CI, 0.468-0.759).
data suggest that GSTP1 expression is not associated with bladder cancer (BC) development, limiting its use as a biomarker for BC management in Morocco. Moreover, difference in GSTP1 expression among BC cases is not due to GSTP1 promoter methylation.
Methylation GSTP1 is associated with Breast Cancer.
Prenatal fine particulate exposure in late pregnancy was associated with impaired childhood lung function and hypermethylation of GSTP1 in nasal epithelium.
The study revealed association of GSTP1 I105V with Infectious Endocarditis, but the disease proved unrelated to GSTP1 A114V polymorphism.
The results of this meta-analysis suggest that GSTP1 hypermethylation induces the inactivation of GSTP1 gene, plays an important role in hepatocarcinogenesis, and is associated with an increased risk of HCC.
The expression levels of LRP and GSTP1 in primary epithelial ovarian cancer were the highest, followed by borderline adenoma tissues, and lowest levels in benign tumor tissues. The difference between resistant gene negative-expression and positive-expression of chemotherapy efficiency, disease free survival time, and recurrence time were statistically significant.
polymorphisms do not have any large effect on risk of cutaneous malignant melanoma [meta-analysis]
There is a multifarious interaction between the DNA repair gene ERCC5 SNPs (rs2094258 and rs873601) and the metabolic gene GSTP1 rs1695, which may form the basis for various inter-individual susceptibilities to atrophic gastritis in Chinese population.
Design and synthesis of 2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors.
The present study findings provide the insights that miR133b reduces cisplatin resistance and its overexpression contributes to the suppression of the malignant growth and aggressiveness of cisplatinresistant nonsmall cell lung cancer cells by targeting GSTP1.
Through translational prospective study, the GSTP1 Ile105Val polymorphism emerges as prognostic marker in de novo large B-cell lymphoma patients.
GSTP1 polymorphism is associated with Cervical Cancer in Human Papilloma Virus Infected patients.
The current analyses suggests significant association was found between GSTM1 variants and the risk of childhood acute lymphoblastic leukemia (ALL), while no association were found between GSTT1 and GSTP1 Ile105Val polymorphism and childhood ALL risk
GSTP1 Ile105Val was associated with increased lung function, reduced risk for lung cancer and tobacco-related cancer, and reduced all-cause mortality in the general population.
the recessive model of GSTP1 g.313A>G is the best fit inheritance model to predict the susceptible gene effect (OR: 2.3, 95% CI: 1.11-4.92, P = 0.020). In conclusion, statistically significant associations of GSTP1 g.313A>G (A/G, G/G) and g.341C>T (C/T) genotypes with coronary artery disease were observed.
The GSTP1 AG genotype of Alzheimer's disease was significantly lower (p = 0.005; OR = 0.57, 95% CI: 0.38-0.84) in the patients (41.1%) than the control group (56.5%).
Study provides evidence that high expression of CLDN6 confers chemoresistance on breast cancer which is mediated by GSTP1, the activity of which is regulated by p53.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS- or IKKbeta-induced production of GM-CSF. These studies indicate a complex role for GSTP in modulating NF-kappaB, which may involve S-glutathionylation of IKK proteins, and interaction with NF-kappaB family members.
GSTP can exert redox regulation in the oxidative ER environment and indicate that, within the ER, GSTP influences the cellular consequences of the UPR through S-glutathionylation of a series of key interrelated proteins. Antioxid.
our study reveals the novel role of GSTP1 in regulation of iNOS by affecting S-nitrosylation, dimerization, and stability.
These observed differences contribute to our understanding of how genetic ablation of GSTP causes different levels of myeloproliferation and migration [corrected]
GSTP1/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.
GSTP1 expression in retina increases with developmental age in mice and accompanies murine retinal maturation.
GSTP knock-out mice display decreased ubiquitination capacity and overall increased susceptibility to oxidative stress.
Report increased GSTP1 in airways of asthmatic mice.
DNIC storage function of GST P1-1 and ability of MRP1 to efflux DNICs are vital in protection against NO cytotoxicity
Gst-pi expression of the prostate cancers are dependent on metastatic site.
GSTP plays a major role in carcinogenesis distinct from its role in detoxification and provides evidence that the enzyme is a key determinant of the proinflammatory tumor environment.
This study analysed the kinetic behaviour of all the various cysteine to alanine mutants of Gstp1. These mutations introduce cooperativity and a novel 'ping pong' mechanism in the case of the C169A mutant.
Sequential catalysis of Aldr1 by glutathione S-transferase P and glutaredoxin may be a general redox switching mechanism that regulates the reduction of protein sulfenic acids to cysteines regulates the reduction of protein sulfenic acids to cysteines
Apc(Min/+)Gstp1/p2(-/-) (Gstp-null Apc(Min)) mice had a 6-fold increase in colon adenoma incidence, and a 50-fold increase in colorectal adenoma multiplicity, relative to Gstp-wt Apc(Min).
role in activating Pi-class glutathione S-transferase gene in conjunction with androgens
These results suggest that GSTpi may play a protective role in the development of spontaneous tumors.
Differential expression of GSTpi contributes to the sensitivity to xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders including Parkinson's disease.
Like Mrp2, GSTpi protein expression increased with pregnane X receptor activation
GSTP1 attenuates the severity of allergic airways disease. However, the efficacy of GSTP1 correlated with mouse strain-dependent variation in Gstp1 expression.
Results suggest that GSTpi expression may be part of the mechanism underlying the ability of glial cells to elicit protection against the mechanisms involved in MPTP-induced neuronal death.
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
, deafness, X-linked 7
, fatty acid ethyl ester synthase III
, glutathione S-transferase P
, GST 7-7
, Glutathione-S-transferase placental enzyme pi type
, Glutathione-S-transferase, placental enzyme pi type
, chain 7
, glutathione S-transferase pi 2
, glutathione S-transferase, pi 2
, glutathione-S-transferase, pi 1
, Glutathione S-transferase P
, GST-pi enzyme
, glutathione S-transferase P 1
, GST YF-YF
, Gst p-1
, gst P1
, preadipocyte growth factor