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Study presents the first demonstration that GBP2 inhibits mitochondrial fission and cell metastasis in breast cancer cells both in vitro and in vivo.
Low GBP2 expression is associated with metastasis in breast cancer.
GBP1 (zeige GBP1 Proteine)/2 are critical effectors of antichlamydial interferon (IFN)gamma (zeige IFNA Proteine)-mediated pathogen clearance via rerouting of bacterial inclusions in macrophages for lysosomal degradation.
Downregulation of MIR (zeige MLXIP Proteine)-433 is associated with myeloproliferative neoplasms.
The in vivo localization of GBP-2 at cellular membranes is regulated by isoprenylation and dimerization.
hGBP-1, hGBP-2 showed dimerization-related GTPase (zeige RACGAP1 Proteine) activity for GMP (zeige NT5C2 Proteine) formation.
Guanylate-binding protein 2 mRNA in peripheral blood leukocytes may have a role in acute cellular rejection after liver transplantation
Sky1p utilizes the same docking groove to bind yeast SR-like protein (zeige PNN Proteine) Gbp2p and phosphorylates all three serines present in a contiguous RS dipeptide stretch
GBP-2 is regulated by p53 (zeige TP53 Proteine) and may have a role in esophageal squamous cell carcinomas
GBP2 can effectively regulate beta-glucan-induced maturation of DCs, thus suppressing the proliferation of T cells.
GBP1 (zeige GBP1 Proteine) GBP2 enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
this study identified guanylate-binding proteins GBP2 and GBP5 as key activators of AIM2 (zeige AIM2 Proteine) during infection with F. novicida.
This study begins to define the properties of mGBP-2 responsible for inhibiting cell spreading.
Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.
the inducible multimerization of mGBP2 is dependent on a functional GTPase (zeige RACGAP1 Proteine) domain.
IRGM (zeige IRGM Proteine) proteins indirectly modulate the localization of GBP2 through a distinct mechanism from that through which they regulate IRG protein localization
mGBP-2 inhibits TNF-alpha (zeige TNF Proteine) activation of endogenous Rac1 and constitutively activate Rac (zeige AKT1 Proteine) can restore NF-kappaB (zeige NFKB1 Proteine) transcription in the presence of mGBP-2. This is a novel mechanism by which IFNs can inhibit the cytokine induction of MMP-9 (zeige MMP9 Proteine) expression.
Both IFN-gamma (zeige IFNG Proteine) and mGBP-2 also inhibit cell spreading initiated by platelet-derived growth factor treatment, which is also accompanied by inhibition of Rac (zeige AKT1 Proteine) activation by mGBP-2.
inhibits replication of both vesicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV); a wild type GTP binding (zeige RND2 Proteine) motif was not required for VSV inhibition but was required for inhibition of EMCV
cDNA sequences were cloned and the genomic structure of porcine GBP1 (zeige GBP1 Proteine) (poGBP1) and GBP2 (poGBP2), was analyzed.
Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP.
GTP-binding protein 2
, guanine nucleotide-binding protein 2
, interferon-induced guanylate-binding protein 2
, guanylate nucleotide binding protein 2
, isoprenylated 67 kDa protein