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Human FCGR2B Protein expressed in Wheat germ - ABIN1353899
Sakamoto, Ito, Hatanaka, Soni, Mori, Sugimura: Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions. in The Journal of biological chemistry 2009
Human FCGR2B Protein expressed in Human Cells - ABIN2002450
Ravetch, Lanier: Immune inhibitory receptors. in Science (New York, N.Y.) 2000
Show all 5 Pubmed References
FcgammaRIIA and FcgammaRIIB both demonstrated increased methylation levels in Kawasaki disease (KD) patients that underwent IVIG treatment. FcgammaRIIA expression influenced the IVIG treatment response of KD patients. The FcgammaRIIA/IIB mRNA expression ratio was greater in KD patients with coronary artery lesion formation.
This first genome-wide association approach for cyclophosphamide response in lupus nephritis patients yielded a robust profile of genetic associations including large-effect SNP in the FCGR2B-FCRLA (zeige FCRLA Proteine) locus, which may provide better insights to cyclophosphamide metabolism and efficacy.
results indicate that FcgammaRIIB is not uniquely able to promote membrane recruitment of SHIP, but rather modulates its function via formation of distinct signaling complexes. Membrane recruitment of SHIP via Syk (zeige SYK Proteine)-dependent mechanisms may be an important factor modulating immunoreceptor signaling.
Fc gamma receptor IIb was significantly elevated in abdominal aortic aneurysm (AAA (zeige APP Proteine)) tissues compared to normal aortas. Fc gamma receptor IIb may be involved in the pathogenesis of AAA (zeige APP Proteine) by regulation of inflammatory reactions.
Fc-gamma receptor (zeige FCGR1A Proteine) polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.
LPS (zeige IRF6 Proteine) activation of TLR4 (zeige TLR4 Proteine) significantly increased MARCH3 (zeige MARCH3 Proteine) expression and that siRNA against MARCH3 (zeige MARCH3 Proteine) prevented the decrease in FcgammaRIIb following LPS (zeige IRF6 Proteine) treatment.
a rare FCGR2B null-variant allele was found, in which a polymorphic stop codon of FCGR2C is introduced into one FCGR2B gene
FcgammaRIIB requires Btk (zeige BTK Proteine) and p38 MAPK (zeige MAPK14 Proteine) to mediate antigen-independent inhibition in human B cells.
The FCGR2B variant leads to reduced serum IL-6 (zeige IL6 Proteine), later disease onset and reduced need for biological treatment, but does not seem to aggravate RA. The TM region variant is associated with a lower activation state of the Tregs and naive and memory B cells.
FcgIIb on GM-CSF (zeige CSF2 Proteine) macrophages has a role in controlling immune complex-mediated inhibition of inflammatory signals
CRP (zeige CRP Proteine) is pathogenic in type-2 diabetes (T2DN). CRP (zeige CRP Proteine) may promote CD32b- NF-kappaB (zeige NFKB1 Proteine) signaling to mediate renal inflammation; whereas, CRP (zeige CRP Proteine) may enhance renal fibrosis in T2DN via CD32b-Smad3 (zeige SMAD3 Proteine)-mTOR (zeige FRAP1 Proteine) signaling.
FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation.
PLCd1 (zeige PLCD1 Proteine) negatively regulates lipopolysaccharide-induced production of IL-1b (zeige IL1B Proteine) and Fc gamma receptor (zeige FCGR1A Proteine)-mediated phagocytosis in macrophages.
The authors concluded that the FcgammaRIIb-SHIP2 (zeige INPPL1 Proteine) axis links Abeta (zeige APP Proteine) neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
This study reports the creation of a mouse model of autoimmunity-associated atherosclerosis by transplanting bone marrow from FcgammaRIIB knockout (FcRIIB(-/-)) mice into LDL receptor (zeige LDLR Proteine) knockout mice.
These results reveal a novel and unexpected function of hepatic Fc-gamma-RIIB in the targeted downregulation of GPVI (zeige GP6 Proteine) in vivo.
Cytokine release was quantified from FVIII(-/-) splenocytes restimulated with FVIII in the absence or presence of different anti-FcgammaRIIB (CD32) Antibodies (anti-CD32 mAbs) over 6 days.
Collectively these findings reveal that by inhibiting eNOS (zeige NOS3 Proteine), endothelial FcgammaRIIB activation by CRP (zeige CRP Proteine) blunts insulin (zeige INS Proteine) delivery to skeletal muscle to cause insulin (zeige INS Proteine) resistance.
Macrophages' activating FcgammaR expression profile are associated with the development of ITP (zeige ITPA Proteine) in Treg-deficient mice.
this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1 (zeige INPP5D Proteine)/2 and Inpp4a (zeige INPP4A Proteine), and accelerates phagosome acidification
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
, Fc fragment of IgG, low affinity II, receptor for (CD32)
, Fc fragment of IgG, low affinity IIb, receptor for (CD32)
, Fc gamma RIIb
, fc-gamma RII-b
, igG Fc receptor II-b
, low affinity immunoglobulin gamma Fc region receptor II-b
, Fc fragment of IgG, low affinity IIb, receptor (CD32)
, Fc fragment of IgG, low affinity IIb, receptor
, IgG Fc gamma receptor II
, fc-gamma RII
, igG Fc receptor II
, low affinity immunoglobulin gamma Fc region receptor II
, Fc gamma RIIB
, fc gamma receptor IIB
, igG Fc receptor II beta
, lymphocyte antigen 17
, FC-gamma RII
, Fc receptor, IgG, low affinity IIb
, low affinity immunoglobulin gamma FC region receptor II
, Fc-gamma RII
, IgG Fc receptor II
, Fc gamma receptor II