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anti-Human EDNRB Antikörper:
anti-Rat (Rattus) EDNRB Antikörper:
anti-Mouse (Murine) EDNRB Antikörper:
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Human Polyclonal EDNRB Primary Antibody für IHC, IHC (p) - ABIN447514
Park, Mima, Li, Rask-Madsen, He, Mizutani, Katagiri, Maeda, Wu, Khamaisi, Preil, Maddaloni, Sørensen, Rasmussen, Huang, King: Insulin decreases atherosclerosis by inducing endothelin receptor B expression. in JCI insight 2016
Show all 2 Pubmed References
Cow (Bovine) Polyclonal EDNRB Primary Antibody für IHC, IHC (p) - ABIN441144
Kobayashi, Yoshimoto, Yamamoto, Kimura, Okuda: Roles of EDNs in regulating oviductal NO synthesis and smooth muscle motility in cows. in Reproduction (Cambridge, England) 2016
Dog (Canine) Polyclonal EDNRB Primary Antibody für ICC, IF - ABIN5541800
Tanaka, Sho, Takayama, Wakatsuki, Matsumoto, Migita, Ito, Hamada, Nakajima: Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma. in British journal of cancer 2014
Human Polyclonal EDNRB Primary Antibody für WB - ABIN927147
Ehrenreich, Nau, Dembowski, Hasselblatt, Barth, Hahn, Schilling, Sirén A-L, Brück: Endothelin b receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus. in Neuroscience 2000
our current findings suggest that human neutrophils display functional ETB receptors with calcium signaling capability, leading to accentuated adhesion to the endothelium.
Endothelin-1 (zeige EDN1 Antikörper) possesses an anti-apoptotic effect in vascular endothelial cells and this effect is mediated, to a great extent, via the activation of EDNRB, with a minor contribution via activation of EDNRA (zeige EDNRA Antikörper).
ETBR function contributes to diminished endothelium-dependent dilation in previously preeclamptic women.
ETA and ETB receptors are present in human haemorrhoids with ETB receptors predominating
An IL2 (zeige IL2 Antikörper)-targeted antibody failed to detect transfected ETB in HEK293 cultures. In contrast, the NT-targeted antibody accurately detected transfected ETB in HEK293 cultures by labeling a 37-kDa band.
In control arteries, ETAR (zeige EDNRA Antikörper) was expressed by vascular smooth muscle cells in the media whereas ETBR was hardly detected. In giant cell arteritis, both ETAR (zeige EDNRA Antikörper) and ETBR receptors were expressed by alphaSMA (zeige ACTA2 Antikörper)-positive cells at the intima-media border. Endothelial cells and inflammatory cells also expressed both ET receptors.
This study concluded that ETB receptors mediate vasodilation in young women, but this effect is lost after menopause.
Our results suggest that EDNRB rs5351 single nucleotide polymorphism is a strong independent predictor of essential hypertension in men of Tatar ethnic origin.
No rare EDNRB variants were identified among 57 patients with Hirschsprung disease.
Taking into account that the cohort we screened was deprived of patients previously found mutated in MITF (zeige MITF Antikörper) (about 15%) and SOX10 (zeige SOX10 Antikörper) (another 15%), our 8% mutation rate indicates that EDNRB heterozygous mutations represent about 5%-6% of all WS2 (zeige MITF Antikörper), making it the third gene of this subtype.
PDE5 (zeige PDE5A Antikörper) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB receptor blockade in the presence of PDE5 (zeige PDE5A Antikörper) inhibition.
ET(A (zeige EDNRA Antikörper))/ET(B) blockade decreased pulmonary vascular resistance but only during exercise.
endothelial endothelin ET(B) receptors induce NO and EDHF mediated vasodilatation in porcine coronary arteries; in organ culture, endothelial endothelin ET(B) receptors are down-regulated
PKC (zeige FYN Antikörper) and MAPK (zeige MAPK1 Antikörper) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries
extracellular ET-1 (zeige EDN1 Antikörper) regulates the abundance of ET-1 (zeige EDN1 Antikörper) mRNA in PAECs, in an ETB receptor-dependent manner, by modulating both mRNA stability and transcription via mechanisms involving receptor endocytosis and both ERK (zeige MAPK1 Antikörper) and p38 MAPK (zeige MAPK14 Antikörper) pathways
Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR (zeige EDNRA Antikörper) antagonists might be beneficial for treatment of laminitis in horses.
both ETA and ETB receptors are involved in the net tonic response to ET-1 (zeige EDN1 Antikörper) in normal laminar veins; a population of ETB receptors may be present on the vascular endothelium and on smooth muscle of laminar veins
Stimulation of ETA and ETB receptors activates native protein kinase C-dependent transient receptor potential channel (TRPC)1 through phospholipid pathways involving phosphoinositol-3,4,5-trisphosphate (PIP)3 and PIP2 in coronary artery myocytes.
ET(B) receptor stimulation relaxes the carbachol precontracted iris sphincter muscle, an effect that is mediated by the ET(B2) receptor subtype, through NO and the release of prostaglandins.
ETB receptor signaling is involved in skin sclerosis and in collagen synthesis by dermal fibroblasts
mmLDL increased the serum concentrations and expression of ICAM-1 (zeige ICAM1 Antikörper) and VCAM-1 (zeige VCAM1 Antikörper) by activating the ERK1/2 pathway, resulting in the expression of ETB receptors and the enhancement of contractile function in vascular smooth muscle.
ETB receptors in vascular smooth muscle make a small but significant contribution to ETB-dependent regulation of BP. These ETB receptors have no effect on vascular contraction or neointimal remodeling.
Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 (zeige EDN1 Antikörper) via upregulation of the ETB receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.
Wnt (zeige WNT2 Antikörper)-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R (zeige MSHR Antikörper) loss.
we show that ET-1 (zeige EDN1 Antikörper) acts selectively through EDNRB on astrocytes-and not oligodendrocyte progenitor cells-to indirectly inhibit remyelination.
EDNRB plays a key role in hypoxia tolerance
The cardiac expression of prepro-endothelin-1 (zeige EDN1 Antikörper) mRNA, endothelin-converting enzyme-1 (zeige ECEL1 Antikörper) mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight
results indicate that the Notch1 (zeige NOTCH1 Antikörper)-STAT3 (zeige STAT3 Antikörper)-ETB(R) axis connects a signaling network that promotes reactive astrocyte proliferation after brain injury
Ednrb-deficient mice showed altered goblet cell differentiation and surface mucus properties characteristic of human Hirschsprung disease.
Differential cell-specific and spatiotemporal expression of the EDN1 (zeige EDN1 Antikörper) system and NOS (zeige NOS Antikörper) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Elevated local expression of ET-1 (zeige EDN1 Antikörper) and Ednra/Ednrb during the peri (zeige PLIN1 Antikörper)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endothelin B receptor
, endothelin receptor non-selective type
, endothelin receptor subtype B
, endothelin-B receptor
, endothelin ETB receptor
, endothelin receptor B
, endothelin receptor type B