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Human CSF3 Protein expressed in Escherichia coli (E. coli) - ABIN987880
Xie, Gorodetsky, Micewicz, Micevicz, Mackenzie, Gaberman, Levdansky, McBride: Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits. in The Journal of investigative dermatology 2013
Mouse (Murine) CSF3 Protein expressed in Escherichia coli (E. coli) - ABIN809713
Nasirikenari, Veillon, Collins, Azadi, Lau: Remodeling of marrow hematopoietic stem and progenitor cells by non-self ST6Gal-1 sialyltransferase. in The Journal of biological chemistry 2014
data provide novel information about the regulation of neutrophil migration in zebrafish, positioning Gcsf-Chr19 as a key signal during the course of an inflammatory process triggered by severe damage
Data indicate that Gcsf is required for the specification and proliferation of hematopoietic stem cells, suggesting that Gcsf represents an ancestral cytokine responsible for the broad support of hematopoietic stem and progenitor cells (HSPCs).
these data provide strong evidence for a role for G-CSF in the development of ACI after burn injury through suppression of EPO (zeige EPO Proteine) signaling in bone marrow erythroid cells.
physiologically produced G-CSF not only acts as a neutrophil mobilizer at the relatively late stage of acute inflammation, but also prevents exaggerated neutrophil mobilization.
data demonstrate that G-CSF is a pivotal driver of the disease progression in the K/BxN serum-transfer arthritis (STA (zeige SULT2A1 Proteine)) model and possibly acts in part by regulating neutrophil numbers in the circulation
SB203580 increases G-CSF expression in macrophages by increasing the stability of G-CSF mRNA via its 3'UTR, and the effect was not due to its inhibition of p38 MAPK (zeige MAPK14 Proteine) activity.
Results suggested that G-CSF plays an important role in preventing colitis, likely through populating immune regulatory macrophages in the intestine.
findings provide convincing evidence that monophosphoryl lipid A-induced G-CSF facilitates early expansion, mobilization, and recruitment of neutrophils to the site of infection after burn injury
Overexpression of VEGF (zeige VEGFA Proteine) may compensate for the G-CSF deficit through preservation of cellular components, including blood vessels, in the postinfarction heart.
G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy.
constitutive activation of the NF-kappaB (zeige NFKB1 Proteine) pathway in CAIX (zeige CA9 Proteine)-depleted cells restored G-CSF secretion
Exposure of Sca-1(+) cells to G-CSF in the culture medium for 72 h induced time-dependent but self-limiting cell cycle acceleration with a restricted effect on the CSC proliferation.
conclusion, there was an elevated lipolysis condition within the FF of Polycystic Ovary Syndrome (PCOS) with metabolic syndrome (MS) patients and the TNF-alpha (zeige TNF Proteine) and G-CSF levels in FF were associated with top-quality embryo percentage.
Oral and periodontal innate immunity is affected by HIV viremia and ART. GCF (zeige GUCY2F Proteine) IL-8 (zeige IL8 Proteine), G-CSF, as well as serum IL-8 (zeige IL8 Proteine), MCP-1 (zeige CCL2 Proteine) and GM-CSF (zeige CSF2 Proteine) may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use.
a set of IL-17A (zeige IL17A Proteine)-regulated genes in keratinocytes, which recapitulate typical psoriasis genes exemplified by DEFB4A (zeige DEFB4 Proteine), S100A7 (zeige S100A7 Proteine), IL19 (zeige IL19 Proteine) and CSF3, based on the differences in the expression profiles of cells stimulated with six cytokines versus cells stimulated with only five cytokines lacking IL-17A (zeige IL17A Proteine).
The results showed that the addition of recombinant IL-1 (zeige IL1A Proteine) markedly increased G-CSF expression in fibroblasts; however, IL-1 (zeige IL1A Proteine) receptor antagonist only partially abrogated KCM-stimulated G-CSF expression, indicating the role of additional keratinocyte-releasable factors
Data reviewed establish that any damage to brain tissue tends to cause an increase in G-CSF and/or GM-CSF (zeige CSF2 Proteine) (G(M)-CSF (zeige CSF1 Proteine)) synthesized by the brain. Glioblastoma cells themselves also synthesize G(M)-CSF (zeige CSF1 Proteine). G(M)-CSF (zeige CSF1 Proteine) synthesized by brain due to damage by a growing tumor and by the tumor itself stimulates bone marrow to shift hematopoiesis toward granulocytic lineages away from lymphocytic lineages.
CD146/MCAM (zeige MCAM Proteine) is the functional galectin-3 (zeige LGALS3 Proteine)-binding ligand on endothelial cell surfaces responsible for galectin-3 (zeige LGALS3 Proteine)-induced secretion of metastasis-promoting cytokines.
These results suggest that G-CSF could decrease the Th1 (zeige TH1L Proteine)/Th2 ratio in the context of immune thrombocytopenic purpura, and elucidate the direct and indirect immunomodulatory mechanisms underlying G-CSF functions in Th1 (zeige TH1L Proteine)/Th2 cells.
GCSF impairs CD8 (zeige CD8A Proteine)(+) T cell functionality by interfering with central activation elements.
High expression of G-CSF is associated with Tongue squamous cell carcinoma.
this study shows that haplotypes consisting of single nucleotide polymorphisms harboring PSMD3 (zeige PSMD3 Proteine), CSF3 and MED24 (zeige MED22 Proteine) genes are associated with asthma in Slovenian patients
Data suggest granulocyte-colony stimulating factor (G-CSF) as a possible candidate for agents in which neutrophils can provide protection.
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene.
colony stimulating factor 3 (granulocyte)
, granulocyte colony-stimulating factor
, granulocyte colony stimulating factor
, Granulocyte colony-stimulating factor