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Studied association of C-C motif chemokine receptor 5 delta 32 variant (CCR5Delta32) and its association with HCV/HIV co-infection, and HCV-related diseases.
Single-cell analysis revealed CCR5 governs PI3K/Akt, ribosomal biogenesis, and cell survival signaling.
These findings support the hypothesis that CCR2-CCR5 genes and their haplotypes are associated with chronic Chagas cardiomyopathy; however, depending on the population studied, different associations can be found.
Antibody blocking experiments confirmed HLA-DR+ Teff cells, but not the fraction depleted of HLA-DR+ effectors, to be resistant to Treg suppression mediated via CCR5 and PD-L1 associated pathways in pulmonary tuberculosis.
In the association analysis of resistant versus susceptible subjects, CCR5Delta32 mutant allele-carriers proved significantly protected against chronic (OR 0.49; 95% CI 0.29-0.83; p-value 0.01) and aggressive (OR 0.46; 95% CI 0.22-0.94; p-value 0.03) periodontitis.
Conditioned media or microparticles released from obese omental adipose tissue increased CD16 and CCR5 expression on CD14(+)CD16(-) monocytes and augmented their migratory capacity towards the conditioned media from obese omental adipose tissue, itself.
The block of the protein kinases phosphorylation mediated by staurosporine treatment abrogates the capture of the chemokine receptor CCR5 (CCR5) signalosome into the early endosomes. This suggests the relevant role of phosphorylation events to form steady receptor-beta-arrestin2 complexes, mediated by an ubiquitination of beta-arrestin2 and a durable phosphorylation of ERK1, which are concentrated into the early endoso...
data suggests that the exposure of myeloid cells to Meth in the context of presence of HIV peptides such as Tat, may affect the number of HIV targets by modulating CCR5 expression, through a combination of DA-dependent and-independent mechanisms.
We use CPRC prostate cancer model and demonstrate that endothelial cells secrete large amount of CCL5 and induces autophagy by suppressing AR expression in prostate cancer cell lines. Consequently, elevated autophagy accelerates focal adhesions proteins disassembly and promoted prostate cancer invasion. Inhibition of both CCL5/CCR5 signaling and autophagy significantly reduces metastasis in vivo
Data provides evidence that CCR5 has an essential role in bone-destructive conditions through the functional regulation of osteoclasts.
A critical role for CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma microenvironment.
these findings emphasize the potential involvement of CCR5 signaling in central nervous system inflammation and damage in multiple sclerosis
As patients with and without CCR5Delta32 mutations were similar in terms of histological activity (p = 0.84) and fibrosis stage (p = 0.20) as well as CCR5 tissue expression, the authors reasonably exclude that this CCR5 mutation is significantly involved in the pathogenesis of chronic hepatitis C.
This study demonstrates that, CCR5 promoter polymorphisms correlate with CD4 T cell loss possibly by regulating CD4 T cell apoptosis in HIV patients.
Results suggest that monocytes from Crohn's disease patients in remission produced high levels of CSF-1 that upregulate CCR5 expression. Consequently, monocytes differentiated in these conditions had a characteristic phenotype and lower production of inflammatory cytokines.
The findings provide genetic and epidemiological evidence for an association of UGT1A and CCR5 polymorphisms with hepatitis B virus infection in Chinese Yi and Yao populations.
Authors also demonstrated that Treg migration to the tumor microenvironment is mediated by CCR5, and these cells are promoting tumor growth via inhibition of antitumor cells such as cytotoxic CD8(+) T cells.
These data indicate that cardiac surgery influences the expression of CD162, CD166 and CD195 and that the intensity of the immune system response, displayed as the change in the CD162, CD166, CD195 expression, varies, depending on the surgical technique used.
the interaction between CCR5 and its ligands promotes the proliferation of CCR5(+) polymorphonuclear-myeloid-derived suppressor cells at the bone marrow
CCR5Delta32 allele is not associated with susceptibility to HIV-1 infection in Iranian population.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCR5 by coronary artery transmural and perivascular cells in a sequential pattern
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CCR5 expression.
CCR5 inhibition may provide a cardioprotective benefit in SIV infection by preventing cardiomyocyte CCR5 signaling.
A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
CCR5 downregulation on CD4(+) T cells by TCR activation has no measurable effect on susceptibility to SAIDS.
CD4 and CD8 T cells are more vulnerable to SIV infection, indicating the the ability to express CCR5 may activate and hassten T cell death by SIV infection in vitro.
Results estimate the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut.
observed a significantly higher loss of CCR5(+) CD45RA(-) CD4(+) T cells in CD8(+) lymphocyte-depleted macaques than in controls
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
This study establishes a role of glial CCR5, unrelated to infective processes, in mediating neurotoxicity due to HIV-1 Tat and the interactive effects of Tat and morphine.
Blockade of CCR5-mediated myeloid derived suppressor cell accumulation enhances anti-PD1 efficacy in gastric cancer
ANG II is up-regulated in serum and heart tissues of mice with EAM and that ANG II significantly drives monocyte/macrophage infiltration through the C-C chemokine receptor 2/5 (CCR2/5) axis.
This study suggested a potential neuroprotection in the absence of CCR5 receptor during global brain ischemia and reperfusion injury.
Studied the effects of CCL5-CCR5 interactions in breast cancer metabolism, and findings suggest that CCL5-CCR5 interactions in the tumor microenvironment modulate metabolic events during tumor onset to promote tumorigenesis.
Loss of CCR5 is associated with astrogliosis, amyloid-beta deposit and impaired memory function.
These findings suggest that CCR5 is likely participating in demyelination in the spinal cord in experimental autoimmune encephalomyelitis
These results demonstrate that CCR5 plays an important role in neuroplasticity, learning and memory, and indicate that CCR5 has a role in the cognitive deficits caused by HIV.
The Ccr5 is crucial in directing T cells toward the Langat virus -infected brain, as well as in suppressing neutrophil-mediated inflammation within the Central Nervous System.
This study showed that CCR5 ablation exacerbated Japanese encephalitis without altering viral burden in the extraneural and CNS tissues, as manifested by increased CNS infiltration of Ly-6C(hi) monocytes and Ly-6G(hi) granulocytes.
this review discusses the role of CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma
These results suggested that CCR5 signaling is involved in embryo loss in Toxoplasma gondii infection during early pregnancy and that apoptosis is associated with embryo loss rather than direct damage to the fetoplacental tissues.
The upregulation of CCR5 on the surface of the CD8(+) T cells increases the number of contacts with Ag-bearing dendritic cells, which ultimately results in increased CD8(+) T cell response to Ag rechallenge.
CCL4-CCR5 axis can contribute to breast cancer metastasis to bone by mediating the interaction between cancer cells and fibroblasts in bone cavity.
Cytokine-induced killer cells interact with tumor lysate-pulsed dendritic cells via CCR5 signaling.
this study shows that diosgenin-mediated anti-allergic effects are associated with increased number of Foxp3+ Treg cells expressing CCR5
CCR5 deficiency increased the production of TNF-alpha following LPS treatment through increased activation of the p38 pathway in the kidney, resulting in renal apoptosis and leukocyte infiltration and led to exacerbation of LPS-induced acute kidney injury.
In West Nile virus infection of the central nervous system, CCR5 activity is required to limit viral burden in the cerebral cortex.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
C-C chemokine receptor type 5
, C-C motif chemokine receptor 5 A159A
, HIV-1 fusion coreceptor
, chemokine receptor CCR5
, C-C CKR-5
, MIP-1 alpha receptor
, chemokine (C-C) receptor 5
, chemokine C-C motif receptor 5
, C-C chemokine receptor 11 like
, CC chemokine receptor 5
, chemokine receptor 5
, CC chemokine receptor type 5
, C-C chemokine receptor 5
, chemokine (C-C motif) receptor 5
, C-C chemokine receptor type 5-like