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we observed an overall protective effect associated to the presence of the CCR5Delta32 allele against RA susceptibility that was evidenced in cities with a lower African genetic component. Our results highlight the importance of assessing the influence of CCR5 under different genetic backgrounds.
results suggest that the CCR5 gene and its product might play a role in the pathogenesis of Crimean-Congo hemorrhagic fever infection
the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia
genetic association studies in population in Poland: Data suggest that CCR5-delta32 gene polymorphism is associated with type 1 diabetes (T1D) and increases risk of celiac disease and autoimmune thyroid disorders in patients with T1D; risk of celiac disease or autoimmune thyroiditis in carriers of 32-bp deletion is more than threefold higher than for non-carriers.
differential distribution of the viral reservoir compartment in CCR5((WT/Delta32)) patients with perinatal HIV infection
The donor CCR5 -2086A/A genotype was associated with a lower incidence of grades 3-4 acute GVHD, which did not improve the survival outcomes. These findings suggest that the recipient CCR5 -2086A/A genotype affects the induction of the graft-versus-tumor effect without augmenting the development of GVHD.
searched for the relationship between single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and 32 base pair deletion in CCR5 coding region (Delta 32) with the human predisposition to development of various clinical presentations of tick-borne encephalitis
Deficiency of CCR5 exacerbates alcoholic fatty liver disease by hepatic inflammation induced by pro-inflammatory cytokines and chemokines and oxidative stress.
CCR5-tropic HIV infection is limited to more differentiated progenitor cells with life spans that are less well understood.
Data provide evidence that CCR5 activation mediates CCL5 (zeige CCL5 Proteine) enhances the proliferation and the invasive capacity of human breast cancer cell lines.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCR5 by coronary artery transmural and perivascular cells in a sequential pattern
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CCR5 expression.
CCR5 inhibition may provide a cardioprotective benefit in SIV infection by preventing cardiomyocyte CCR5 signaling.
A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
CCR5 downregulation on CD4(+) T cells by TCR activation has no measurable effect on susceptibility to SAIDS.
CD4 and CD8 T cells are more vulnerable to SIV infection, indicating the the ability to express CCR5 may activate and hassten T cell death by SIV infection in vitro.
Results estimate the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut (zeige GUSB Proteine).
observed a significantly higher loss of CCR5(+) CD45RA(-) CD4 (zeige CD4 Proteine)(+) T cells in CD8 (zeige CD8A Proteine)(+) lymphocyte-depleted macaques than in controls
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 (zeige CXCR4 Proteine) for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 (zeige CXCR4 Proteine) almost exclusively
This study suggested a potential neuroprotection in the absence of CCR5 receptor during global brain ischemia and reperfusion injury.
Studied the effects of CCL5-CCR5 interactions in breast cancer metabolism, and findings suggest that CCL5-CCR5 interactions in the tumor microenvironment modulate metabolic events during tumor onset to promote tumorigenesis.
Loss of CCR5 is associated with astrogliosis, amyloid-beta deposit and impaired memory function.
These findings suggest that CCR5 is likely participating in demyelination in the spinal cord in experimental autoimmune encephalomyelitis
These results demonstrate that CCR5 plays an important role in neuroplasticity, learning and memory, and indicate that CCR5 has a role in the cognitive deficits caused by HIV.
The Ccr5 is crucial in directing T cells toward the Langat virus -infected brain, as well as in suppressing neutrophil-mediated inflammation within the Central Nervous System.
This study showed that CCR5 ablation exacerbated Japanese encephalitis without altering viral burden in the extraneural and CNS tissues, as manifested by increased CNS infiltration of Ly-6C(hi) monocytes and Ly-6G(hi) granulocytes.
this review discusses the role of CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma
These results suggested that CCR5 signaling is involved in embryo loss in Toxoplasma gondii infection during early pregnancy and that apoptosis is associated with embryo loss rather than direct damage to the fetoplacental tissues.
The upregulation of CCR5 on the surface of the CD8 (zeige CD8A Proteine)(+) T cells increases the number of contacts with Ag-bearing dendritic cells, which ultimately results in increased CD8 (zeige CD8A Proteine)(+) T cell response to Ag rechallenge.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
C-C chemokine receptor type 5
, C-C motif chemokine receptor 5 A159A
, HIV-1 fusion coreceptor
, chemokine receptor CCR5
, C-C CKR-5
, MIP-1 alpha receptor
, chemokine (C-C) receptor 5
, chemokine C-C motif receptor 5
, C-C chemokine receptor 11 like
, CC chemokine receptor 5
, chemokine receptor 5
, CC chemokine receptor type 5
, C-C chemokine receptor 5
, chemokine (C-C motif) receptor 5
, C-C chemokine receptor type 5-like