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these findings emphasize the potential involvement of CCR5 signaling in central nervous system inflammation and damage in multiple sclerosis
As patients with and without CCR5Delta32 mutations were similar in terms of histological activity (p = 0.84) and fibrosis stage (p = 0.20) as well as CCR5 tissue expression, the authors reasonably exclude that this CCR5 mutation is significantly involved in the pathogenesis of chronic hepatitis C.
This study demonstrates that, CCR5 promoter polymorphisms correlate with CD4 (zeige CD4 Proteine) T cell loss possibly by regulating CD4 (zeige CD4 Proteine) T cell apoptosis in HIV patients.
Results suggest that monocytes from Crohn's disease patients in remission produced high levels of CSF-1 that upregulate CCR5 expression. Consequently, monocytes differentiated in these conditions had a characteristic phenotype and lower production of inflammatory cytokines.
The findings provide genetic and epidemiological evidence for an association of UGT1A and CCR5 polymorphisms with hepatitis B virus infection in Chinese Yi and Yao populations.
Authors also demonstrated that Treg migration to the tumor microenvironment is mediated by CCR5, and these cells are promoting tumor growth via inhibition of antitumor cells such as cytotoxic CD8 (zeige CD8A Proteine)(+) T cells.
These data indicate that cardiac surgery influences the expression of CD162 (zeige SELPLG Proteine), CD166 (zeige ALCAM Proteine) and CD195 and that the intensity of the immune system response, displayed as the change in the CD162 (zeige SELPLG Proteine), CD166 (zeige ALCAM Proteine), CD195 expression, varies, depending on the surgical technique used.
the interaction between CCR5 and its ligands promotes the proliferation of CCR5(+) polymorphonuclear-myeloid-derived suppressor cells at the bone marrow
engineered CCR5Delta32/Delta32 mutations endowed CD4 (zeige CD4 Proteine)+ U87 cells with resistance against HIV1 infection; this sitespecific, sizecontrolled and homozygous DNA deletion technique was able to induce precise genomic editing
KLF5-regulating cancer-associated fibroblasts affect gastric cancer cells progression by CCL5 secretion and activation of CCR5.
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCR5 by coronary artery transmural and perivascular cells in a sequential pattern
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CCR5 expression.
CCR5 inhibition may provide a cardioprotective benefit in SIV infection by preventing cardiomyocyte CCR5 signaling.
A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
CCR5 downregulation on CD4(+) T cells by TCR activation has no measurable effect on susceptibility to SAIDS.
CD4 and CD8 T cells are more vulnerable to SIV infection, indicating the the ability to express CCR5 may activate and hassten T cell death by SIV infection in vitro.
Results estimate the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut (zeige GUSB Proteine).
observed a significantly higher loss of CCR5(+) CD45RA(-) CD4 (zeige CD4 Proteine)(+) T cells in CD8 (zeige CD8A Proteine)(+) lymphocyte-depleted macaques than in controls
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 (zeige CXCR4 Proteine) for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 (zeige CXCR4 Proteine) almost exclusively
Blockade of CCR5-mediated myeloid derived suppressor cell accumulation enhances anti-PD1 (zeige PDCD1 Proteine) efficacy in gastric cancer
ANG II is up-regulated in serum and heart tissues of mice with EAM and that ANG II significantly drives monocyte/macrophage infiltration through the C-C chemokine receptor 2/5 (CCR2/5) axis.
This study suggested a potential neuroprotection in the absence of CCR5 receptor during global brain ischemia and reperfusion injury.
Studied the effects of CCL5-CCR5 interactions in breast cancer metabolism, and findings suggest that CCL5-CCR5 interactions in the tumor microenvironment modulate metabolic events during tumor onset to promote tumorigenesis.
Loss of CCR5 is associated with astrogliosis, amyloid-beta deposit and impaired memory function.
These findings suggest that CCR5 is likely participating in demyelination in the spinal cord in experimental autoimmune encephalomyelitis
These results demonstrate that CCR5 plays an important role in neuroplasticity, learning and memory, and indicate that CCR5 has a role in the cognitive deficits caused by HIV.
The Ccr5 is crucial in directing T cells toward the Langat virus -infected brain, as well as in suppressing neutrophil-mediated inflammation within the Central Nervous System.
This study showed that CCR5 ablation exacerbated Japanese encephalitis without altering viral burden in the extraneural and CNS tissues, as manifested by increased CNS infiltration of Ly-6C(hi) monocytes and Ly-6G(hi) granulocytes.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
C-C chemokine receptor type 5
, C-C motif chemokine receptor 5 A159A
, HIV-1 fusion coreceptor
, chemokine receptor CCR5
, C-C CKR-5
, MIP-1 alpha receptor
, chemokine (C-C) receptor 5
, chemokine C-C motif receptor 5
, C-C chemokine receptor 11 like
, CC chemokine receptor 5
, chemokine receptor 5
, CC chemokine receptor type 5
, C-C chemokine receptor 5
, chemokine (C-C motif) receptor 5
, C-C chemokine receptor type 5-like