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Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
defensin, alpha 1, myeloid-related sequence
, defensin, alpha 2
, myeloid-related sequence
, neutrophil defensin 1
, alpha-defensin 1
, defensin related cryptdin peptide 1
, defensin-related cryptdin peptide
, defensin alpha 1
, Paneth cell-specific alpha-defensin 2
, alpha-defensin 5, Paneth cell-specific
, defensin NP-2
, neutrophil antibiotic peptide NP-1
, neutrophil antibiotic peptide NP-2
, neutrophil defensin 2
, Neutrophil defensin 1
, Neutrophil defensin 3
, neutrophil defensin 8