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anti-Human alpha Defensin 1 Antikörper:
anti-Mouse (Murine) alpha Defensin 1 Antikörper:
anti-Rat (Rattus) alpha Defensin 1 Antikörper:
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Human Polyclonal alpha Defensin 1 Primary Antibody für ELISA, WB - ABIN2473294
Castañeda-Delgado, Cervantes-Villagrana, Serrano-Escobedo, Frausto-Lujan, Rivas-Santiago, Enciso-Moreno, Rivas-Santiago: Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection. in Memórias do Instituto Oswaldo Cruz 2014
Human Polyclonal alpha Defensin 1 Primary Antibody für ELISA, IHC - ABIN4279832
Chang, Vargas, DelPortillo, Klotman: Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. in The Journal of clinical investigation 2005
DEFA1, DEFA3 (zeige DEFa3 Antikörper), and PPBP (zeige PPBP Antikörper) expression was significantly increased in hyperlipidemia and coronary heart disease patients compared with controls.
HNP1 upregulation of cytokine expression in pDCs was inhibited by blockade of NF-kappaB (zeige NFKB1 Antikörper) activation or knockdown of IRF1 (zeige IRF1 Antikörper), demonstrating the importance of these two signaling events in HNP1-induced pDC (zeige PNKD Antikörper) activation.
these results demonstrate that HNPs1-3 may be potent inhibitors of ADAMTS13 (zeige ADAMTS13 Antikörper) activity, likely by binding to the central A2 domain of VWF (zeige VWF Antikörper) and physically blocking ADAMTS13 (zeige ADAMTS13 Antikörper) binding.
Increased alpha-defensin (zeige DEF Antikörper) expression is associated with risk of coronary heart disease in hyperlipidemia patients.
Levels in sera and CSF (zeige CSF2 Antikörper) were elevated in Alzheimer disease patients compared with controls.
the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases.
Increased levels of neutrophil defensin 1, apolipoprotein E (zeige APOE Antikörper), clusterin (zeige CLU Antikörper), and zinc-alpha-2-glycoprotein (zeige AZGP1 Antikörper) are present in carotid atherosclerotic plaque secretomes.
HNP1 functions as a "molecular brake" on macrophage-driven inflammation, ensuring both pathogen clearance and the resolution of inflammation with minimal bystander tissue damage.
HP1 binding to the chromosomal passenger complex becomes particularly important when Aurora B (zeige AURKB Antikörper) phosphorylates kinetochore targets to eliminate erroneous microtubule attachments
data demonstrate that HNP-1 induces IL-8 production not only through P2Y6, but also through additional P2 receptors via an ERK1/2-dependent mechanism in intestinal epithelial cells.
Decreased alpha-defensin (zeige DEF Antikörper) is associated with intestinal inflammation in a model of inflammatory bowel disease.
cryptdin-1 and cryptdin-4 exhibit circadian oscillation
the Arg5-Glu13 salt bridge in alpha-defensin (zeige DEF Antikörper) is conserved for defensin (zeige DEF Antikörper) in vivo stability
MMP-7 (zeige MMP7 Antikörper) activates mouse paneth cell pro-alpha-defensins
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
defensin, alpha 1, myeloid-related sequence
, defensin, alpha 2
, myeloid-related sequence
, neutrophil defensin 1
, alpha-defensin 1
, defensin related cryptdin peptide 1
, defensin-related cryptdin peptide
, defensin alpha 1
, Paneth cell-specific alpha-defensin 2
, Neutrophil defensin 1
, Neutrophil defensin 3
, neutrophil defensin 8