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Homozygous Alu element insertion in the FBP1 gene is associated with Fructose-1,6-bisphosphatase deficiency.
decreased levels of FBP1 may be used as a predictor for poor prognosis of cervical cancer patients
Study identified for the first time that HNF4alpha (zeige HNF4A Proteine) and C/EBPalpha (zeige CEBPA Proteine) are important transcriptional regulators for FBP1 expression in human hepatoma HepG2 cells.
FBP1 mutation was associated with fructose-1,6-bisphosphatase deficiency
Results identified FBP1 as a promising acute liver failure (ALF (zeige GTF2A1L Proteine)) biomarker among energy metabolism-related proteins. It may serve as a short-term prognosis indicator for ALF (zeige GTF2A1L Proteine), with higher serum level of FBP1 correlated with higher ALF (zeige GTF2A1L Proteine)-related mortality in human studies.
Here, the first crystal structure of human liver FBPase in the R-state conformation is presented, determined at a resolution of 2.2 A in a tetragonal setting that exhibits an unusual arrangement of noncrystallographic symmetry (NCS) elements.
Studied association of fructose 1,6-bisphosphatase 1 (FBP1) expression with fluorine 18 ((18)F) fluorodeoxyglucose (FDG (zeige SMUG1 Proteine)) accumulation in patients with hepatocellular carcinoma. Found that in patients with HCC (zeige FAM126A Proteine), both 18F FDG (zeige SMUG1 Proteine) accumulation and tumor grade (from differentiated to undifferentiated) were inversely correlated with the expression of FBP1.
These findings indicate that FBP1 appears to be a tumor suppressor in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)). Strategies to restore the levels and activities of FBP1 might be developed to treat patients with HCC (zeige FAM126A Proteine).
FBP1 underexpression is associated with Tumor Progression in Hepatocellular Carcinoma.
fructose-1,6-bisphosphatase 1 facilitated co-action between Bcl-2 (zeige BCL2 Proteine) and Beclin 1 (zeige BECN1 Proteine), which may be important in the mechanism of fructose-1,6-bisphosphatase 1-mediated mitophagy inhibition. In summary, loss of mitophagy by fructose-1,6-bisphosphatase 1-mediated repression promotes apoptosis in breast cancer
The results suggested that the FBP1 (zeige FBP2 Proteine) signaling pathway may serve an important role in normal follicle growth and hyperandrogenisminduced abnormal development, which may be associated with abnormal glucose metabolism induced by high concentrations of testosterone.
The Identification of FBPase interacting partners with mass spectrometry reveals a set of nuclear proteins involved in cell cycle regulation, mRNA processing and in stabilization of genomic DNA structure.
FBPase plays an important role in regulating glucose sensing and insulin (zeige INS Proteine) secretion of beta-cells and serves a promising target for diabetes treatment.
Data show that NF-kappaB (zeige NFKB1 Proteine) functions downstream of Ras to promote epigenetic downregulation of FBP1 (zeige FBP2 Proteine).
Directed mutations, kinetics, and structure determinations link the central cavity of FBP to AMP (zeige TMPRSS5 Proteine)/fructose 2,6-bisphosphate synergism.
The AMP (zeige TMPRSS5 Proteine)/Mg(2 (zeige MCOLN1 Proteine)+) and AMP (zeige TMPRSS5 Proteine)/Zn(2+) complexes of Asp (zeige ASIP Proteine)(10) FBPase are in intermediate quaternary conformations.
each subunit in the wild-type tetramer can independently achieve maximum velocity when activated by Mg(2 (zeige MCOLN1 Proteine)+); findings are fully consistent with a mechanism of cooperativity that arises from within a single subunit of fructose-1,6-bisphosphatase.
Ca2 (zeige CA2 Proteine)+ appears to be a strong inhibitor of muscle FBPase (fructose 1,6-diphosphatase).
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
, FBPase 1
, fructose-bisphosphatase 1
, growth-inhibiting protein 17
, D-fructose-1,6-bisphosphate 1-phosphohydrolase 3
, FBPase brain isoform
, FBPase liver
, fructose-1,6-bisphosphatase 1
, fructose-1,6-bisphosphatase isozyme 3
, fructose 1,6-bisphosphatase
, Fructose-16- biphosphatase
, fructose-1,6- biphosphatase 1
, fructose-1,6-bisphosphatase 1, like
, fructose-bisphosphatase 1 S homeolog