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Here, the first crystal structure of human liver FBPase in the R-state conformation is presented, determined at a resolution of 2.2 A in a tetragonal setting that exhibits an unusual arrangement of noncrystallographic symmetry (NCS) elements.
Studied association of fructose 1,6-bisphosphatase 1 (FBP1) expression with fluorine 18 ((18)F) fluorodeoxyglucose (FDG (zeige SMUG1 Proteine)) accumulation in patients with hepatocellular carcinoma. Found that in patients with HCC (zeige FAM126A Proteine), both 18F FDG (zeige SMUG1 Proteine) accumulation and tumor grade (from differentiated to undifferentiated) were inversely correlated with the expression of FBP1.
These findings indicate that FBP1 appears to be a tumor suppressor in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)). Strategies to restore the levels and activities of FBP1 might be developed to treat patients with HCC (zeige FAM126A Proteine).
The redistribution of FBP3 (zeige FUBP3 Proteine) in subcellular compartments was observed after Enterovirus 71 (EV71) infection, and the decreased expression of FBP3 (zeige FUBP3 Proteine) in host neuronal cells markedly inhibited viral replication. The results reveal various host proteins that potentially interact with the EV71 5'UTR in neuronal cells, and study found that FBP3 (zeige FUBP3 Proteine) could serve as a positive regulator in host cells.
FBP1 underexpression is associated with Tumor Progression in Hepatocellular Carcinoma.
fructose-1,6-bisphosphatase 1 facilitated co-action between Bcl-2 (zeige BCL2 Proteine) and Beclin 1 (zeige BECN1 Proteine), which may be important in the mechanism of fructose-1,6-bisphosphatase 1-mediated mitophagy inhibition. In summary, loss of mitophagy by fructose-1,6-bisphosphatase 1-mediated repression promotes apoptosis in breast cancer
Downregulation of FBP1 promotes gastric cancer metastasis by facilitating EMT (zeige ITK Proteine) and acts as a potential prognostic factor and therapeutic target in gastric cancer.
we show that EV71 viral proteinase 2A is capable of cleaving far upstream element-binding protein 1 (FBP1), a positive internal ribosome entry sitet rans-acting factor that directly binds to the EV71 5' UTR linker region to promote viral IRES-driven translation
Cox (zeige COX8A Proteine) multivariate regression analysis demonstrated that DUOX1 (zeige DUOX1 Proteine), GLS2 (zeige GLS2 Proteine), FBP1 and age were independent risk factors for the prognosis of HCC (zeige FAM126A Proteine) patients after surgery
Elevated FBP1 is a critical modulator in breast cancer progression by altering glucose metabolism and the activity of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway.
The Identification of FBPase interacting partners with mass spectrometry reveals a set of nuclear proteins involved in cell cycle regulation, mRNA processing and in stabilization of genomic DNA structure.
FBPase plays an important role in regulating glucose sensing and insulin (zeige INS Proteine) secretion of beta-cells and serves a promising target for diabetes treatment.
Data show that NF-kappaB (zeige NFKB1 Proteine) functions downstream of Ras to promote epigenetic downregulation of FBP1 (zeige FBP2 Proteine).
Directed mutations, kinetics, and structure determinations link the central cavity of FBP to AMP (zeige TMPRSS5 Proteine)/fructose 2,6-bisphosphate synergism.
The AMP (zeige TMPRSS5 Proteine)/Mg(2 (zeige MCOLN1 Proteine)+) and AMP (zeige TMPRSS5 Proteine)/Zn(2+) complexes of Asp (zeige ASIP Proteine)(10) FBPase are in intermediate quaternary conformations.
each subunit in the wild-type tetramer can independently achieve maximum velocity when activated by Mg(2 (zeige MCOLN1 Proteine)+); findings are fully consistent with a mechanism of cooperativity that arises from within a single subunit of fructose-1,6-bisphosphatase.
Ca2 (zeige CA2 Proteine)+ appears to be a strong inhibitor of muscle FBPase (fructose 1,6-diphosphatase).
May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression.
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
, FBPase 1
, fructose-bisphosphatase 1
, growth-inhibiting protein 17
, D-fructose-1,6-bisphosphate 1-phosphohydrolase 3
, FBPase brain isoform
, FBPase liver
, fructose-1,6-bisphosphatase 1
, fructose-1,6-bisphosphatase isozyme 3
, fructose 1,6-bisphosphatase
, FUSE-binding protein 3
, far upstream element-binding protein 3
, Fructose-16- biphosphatase
, fructose-1,6- biphosphatase 1
, fructose-1,6-bisphosphatase 1, like
, fructose-bisphosphatase 1 S homeolog