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This study also validated the interaction between HAP1 and Sec23A (zeige SEC23A Proteine) using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins
findings provide evidence that endogenous APE1 (zeige APEX1 Proteine) protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury
HAP1 co-localizes with synapsin I (zeige SYN1 Proteine) in cortical neurons as discrete puncta
Suppression of Ape1/Ref-1 (zeige APEX1 Proteine) redox function leads to an increased cell surface retention of IL-12 (zeige IL12A Proteine) and enhances Th1 (zeige HAND1 Proteine) responses.
findings suggest that Hap1 is important for insulin (zeige INS Proteine) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (zeige CACNA1C Proteine), providing new insight into the mechanisms that regulate insulin (zeige INS Proteine) release from pancreatic beta-cells.
Is closely associated with upregulation of the Ref1 (zeige THOC4 Proteine)/Nrf2 (zeige NFE2L2 Proteine) signalling pathway.
Results show the stimulatory effect of PARP-1 (zeige PARP1 Proteine) on APE1 (zeige APEX1 Proteine)-dependent base excision repair (BER). PARP-1 (zeige PARP1 Proteine) and APE1 (zeige APEX1 Proteine) appear to have a functional interaction in BER since PARP-1 (zeige PARP1 Proteine) can stimulate the strand incision activity of APE1 (zeige APEX1 Proteine).
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (zeige BCR Proteine) on microtubules to regulate neuronal differentiation.
increases in APEX1 (zeige APEX1 Proteine) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (zeige APEX1 Proteine) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells
HAP1 (zeige APEX1 Proteine) is expressed in endocrine cells of the human gut (zeige GUSB Proteine).
data fully support that HAP1 (zeige APEX1 Proteine) is a GKAP (zeige DLGAP1 Proteine), anchoring specifically to the cGMP-dependent protein kinase (zeige CDK7 Proteine) isoform Ibeta, and provide further evidence that also PKG (zeige PRKG1 Proteine) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (zeige APEX1 Proteine) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (zeige APEX1 Proteine) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (zeige APEX1 Proteine) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (zeige APEX1 Proteine) co-localizes and associates with APP (zeige APP Proteine) in physiological conditions of mouse and human brain.
WT HTT (zeige HTT Proteine) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (zeige PCM1 Proteine)).
HAP1 (zeige APEX1 Proteine)/stigmoid body interacts with the normal ataxin-3 (zeige ATXN3 Proteine) through Josephin (zeige ATXN3 Proteine) domain
sortilin (zeige SORT1 Proteine) stabilizes the proBDNF.HAP1 complex
ADORA2A (zeige ADORA2A Proteine), but not HAP1 (zeige APEX1 Proteine) or OGG1 (zeige OGG1 Proteine), may have a role in age at onset in Huntington's disease
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
AP endonuclease 1
, APEX nuclease
, DNA-(apurinic or apyrimidinic site) lyase
, apurinic-apyrimidinic endonuclease 1
, redox factor-1
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)