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These studies revealed a previously unappreciated role for WNT11 for dorsal mesenchymal protrusion (DMP) formation and distinct tissue-specific requirements for WNT11 in outflow tract and DMP development.
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Wnt4 and Wnt11 cooperatively contribute to mammalian neuromuscular junction formation.
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Results provide evidence that Wnt11 is involved in the organization of kidney tubules through the planar cell polarity pathway taking part in fine-tuning of nephrogenesis.
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under tensile stress, miR-154-5p negatively regulates ADSCs osteogenic differentiation through the Wnt/PCP pathway by directly targeting Wnt11
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a mechanistic link between E-cadherin loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso-dependent expression of Wnt11, is reported.
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Studied groups of embryoid bodies (EBs) with different starting numbers of ESCs & found differential gene expression patterns for Wnt5a & Wnt11. Wnt11 inc'd the percentage of beating EBs by upregulating expression of cardiac-specific genes.
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Data show that Wnt5a and Wnt11 are required for proper patterning of the neural tube and somites by regulating notochord formation.
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These results provide formal genetic proof that the majority of the endocardium and myocardium diverge by mid-gastrulation in the mouse, and suggest a tight spatial and temporal control of Wnt11 expression in the myocardial lineage.
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Wnt5a/Wnt11 inhibit beta-catenin to promote SHF development through Caspase-dependent Akt degradation
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Notch1-induced WISP-1 expression appeared to be Wnt11-dependent, but Wnt1-independent
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The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms.
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demonstrates that the combination of Wnt11 and BMP-2 effectively promotes cardiomyogenic differentiation of BM-MSCs in vitro. The synergistic effect of Wnt11 and BMP-2 on the cardiomyogenic differentiation of BM-MSCs is further enhanced in myocardium
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all the TGF-beta, Wnt11, and JNK targets were activated in a unilateral ureteral obstruction (UUO) model of renal fibrosis in vivo.
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Transplantation of MSC(Wnt11) improved cardiac function. The release of Wnt11 and other factors from transplanted MSC(Wnt11) is more likely responsible for protection of native CM at risk.
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Wnt11 is involved in the protection of the host intestinal cells by blocking the invasion of pathogenic bacteria, suppressing inflammation, and inhibiting apoptosis.
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noncanonical Wnt (Wnt11) enhanced cardiomyocyte differentiation while preventing stabilization of the beta-catenin protein, suggesting active repression of canonical Wnt signals
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GLI3 repressor controls nephron number by regulating ureteric tip cell expression of Wnt11 and Ret
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Wnt-11 signalling serves as a critical cell adhesion cue for the organization of the cardiomyocytes in the developing ventricular wall, which is essential for the establishment of a functional heart.
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Data show that the higher expression of WNT5a in smaller EBs enhanced endothelial cell differentiation, and in contrast, the increased expression of WNT11 enhanced cardiogenesis.
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Wnt11 and Ret/Gdnf cooperate in coordinating ureteric branching by maintaining a balance of Wnt11-expressing ureteric epithelium and Gdnf-expressing mesenchyme in developing kidney