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Human Monoclonal PKN2 Primary Antibody für FACS, IHC - ABIN969363
Cornelis, Qi, Zhang, Kraft, Manson, Cai, Hunter, Hu: Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. in Annals of internal medicine 2009
Steady-state kinetic analysis revealed that PKN1 (zeige PKN1 Antikörper)-3 follows a sequential ordered Bi-Bi (zeige CACNA1A Antikörper) kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors.
PKN2 knockdown in vitro decreased insulin-stimulated glucose uptake, incorporation into glyco (zeige PRKAA1 Antikörper)gen, and oxidation. Thus, PKN2 alters key signaling pathways and transcriptional networks to regulate glucose and lipid metabolism.
Helicobacter pylori CagA (zeige S100A8 Antikörper) interacts with PRK2 and inhibits its kinase activity.
TXA2 (zeige TBXA2R Antikörper)-mediated neoplastic responses in prostate adenocarcinoma PC-3 (zeige PCSK1 Antikörper) cells occur through a PRK1 (zeige PKN1 Antikörper)/PRK2-dependent mechanism.
findings demonstrate that Yersinia enterocolitica rYopM interacts with RSK1 (zeige RPS6KA1 Antikörper) and PRK2 following cell-penetration
Regulation of protein kinase C-related (zeige PKN1 Antikörper) protein kinase 2 (zeige PKC Antikörper) (PRK2) by an intermolecular PRK2-PRK2 interaction mediated by Its N-terminal domain.
these findings suggest that Hsp90 (zeige HSP90 Antikörper) plays a critical role in the regulation of HCV RNA polymerase phosphorylation via the PDK1 (zeige PDK1 Antikörper)-PRK2 signaling pathway.
PKN (zeige PKN1 Antikörper) isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It
Rho binding is essential for PRK2 function and facilitates PRK2 recruitment to junctions. Kinase-dead PRK2 acts as a dominant-negative mutant and prevents apical junction formation.
Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.
In mature skeletal muscle, in vivo PKN2 knockdown decreased glucose uptake and increased AMPK (zeige PRKAA1 Antikörper) phosphorylation. Thus, PKN2 alters key signaling pathways and transcriptional networks to regulate glucose and lipid metabolism.
Mechanistically, Yersinia pseudotuberculosis YopM recruits and activates the mouse host kinases PRK1 (zeige PKN1 Antikörper) and PRK2 to negatively regulate pyrin (zeige MEFV Antikörper) by phosphorylation.
PKN2 formed complexes with Cdo (zeige CDO1 Antikörper), APPL1 (zeige APPL1 Antikörper) and AKT (zeige AKT1 Antikörper) via its C-terminal region and this interaction appeared to be important for induction of AKT (zeige AKT1 Antikörper) activity as well as myoblast differentiation.
To unravel the in vivo physiological function of PKN2, we targeted the PKN2 gene. Constitutive disruption of the mouse PKN2 gene resulted in growth retardation and lethality before embryonic day (E) 10.5. PKN2(-/-) embryo did not undergo axial turning and showed insufficient closure of the neural tube.Mouse embryonic fibroblasts (MEFs) derived from PKN2(-/-) embryos at E9.5 failed to grow.
Yersinia pseudotuberculosis mutants expressing YopM proteins unable to interact with either RSK1 (zeige RPS6KA1 Antikörper) or PRK2 were defective for virulence in this assay, indicating that both interaction domains are important for YopM to promote pathogenesis.
phospholipid-regulated protein kinase, phosphorylates ribosomal protein S6\; may play a role in hepatic regulation
, cardiolipin-activated protein kinase Pak2
, protein kinase C-like 2
, protein-kinase C-related kinase 2
, serine/threonine-protein kinase N2
, serine/threonine kinase 7
, p140 kinase
, protease-activated kinase 2
, protein kinase N2
, protein kinase C-related kinase 2
, serine/threonine-protein kinase N2-like