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data suggest that NFASC is a novel regulator of non-small cell lung cancer cell motility and support a role of NFASC in the regulation of non-small cell lung cancer progression
identified neurofascin as the target of the autoantibodies in Chronic inflammatory demyelination polyneuropathy patients.
-NF155 IgG4 antibodies were associated with a subgroup of patients with CIDP showing a younger age at onset, ataxia, tremor, CNS demyelination, and a poor response to IV immunoglobulin.
Anti-neurofascin antibody is frequently present in patients with CCPD.
Three neuronal proteins (Huntingtin interacting protein 1 (zeige HIP1 Proteine), neurofascin, and olfactomedin-like 2a) are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent (zeige SFRP5 Proteine) formation.
gliomedin (zeige GLDN Proteine), NF186, and contactin are novel target antigens in Guillain-Barre syndrome
Neurofascin isoforms of 186, 180, 166 and 155 kDa are generated by alternative splicing and provide a switch between neuronal plasticity and stability. (Review)
Cerebellar pinceau organization requires coordinated mechanisms involving specific neurofascin functions in both Purkinje and basket neurons.
Fibronectin (zeige FN1 Proteine) type III-like domains of neurofascin-186 protein mediate gliomedin (zeige GLDN Proteine) binding and its clustering at the developing nodes of Ranvier
two crystal structures of a dimeric form of the headpiece of neurofascin
we identify QKI (zeige QKI Proteine) as the long-sought regulator of Neurofascin alternative splicing
P0/NFasc Interaction critical for the integrity of paranodal/nodal structures, but not for the stability of myelin
Neurofascin 140 is essential for assembly of the node of Ranvier in embryogenesis.
In embryonic mouse axons, AnkG is expressed at the beginning of axonogenesis at E9.5 and initially distributed homogeneously along the entire growing axon. From E11.5 the protein progressively becomes restricted to the proximal axon.
the apparent dependency on sulfatide for maintaining Nfasc155 and MAG (zeige MAG Proteine) associations is intriguing since the fatty acid composition of sulfatide is altered and paranodal ultrastructure is compromised in multiple sclerosis
Neurofascin is O-mannosylated and the glycosylation sites have been mapped.
We propose that neurofascin optimizes communication between mature neurons by anchoring the key elements of the adult axon initial segment complex.
Results suggest that neurofascin-dependent assembly of the nodal complex acts as a molecular boundary, facilitating axonal domain organization and saltatory conduction along myelinated axons.
Nfasc isoforms use distinct protein-protein interaction modules to organize and stabilize specific axonal domains in myelinated axons: loss of Nfasc immunoglobulin domains 5 and 6 in mice mimics complete ablation of Nfasc.
In both mouse and human samples, the expression pattern of neurofascin 155(high) and neurofascin 155(low) is altered coincident with paranodal decay.
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
, neurofascin homolog
, neurofascin homolog (chicken)
, neurofascin homolog (chicken) isoform 1
, neurofascin homolog (chicken) isoform 2
, neurofascin homolog (chicken) isoform 3