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Human ITGB1 Protein expressed in Wheat germ - ABIN2752830
Ahn, Mohamedali, Anand, Cheruku, Birch, Sowmya, Cantor, Ranganathan, Inglis, Frank, Agrez, Nice, Baker: Characterization of the interaction between heterodimeric ?v?6 integrin and urokinase plasminogen activator receptor (uPAR) using functional proteomics. in Journal of proteome research 2014
Findings demonstrate the neurotrophin (zeige BDNF Proteine), BDNF (zeige BDNF Proteine)-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (zeige MAG Proteine) .
Findings identify beta(1)-integrin as an important functional cargo during Ca(2+)-dependent rapid endocytosis stimulated by a diffusible guidance cue in Xenopus spinal neurons.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
integrin alpha4beta1 mediates the inhibitory effect of oncofetal Fibronectin (zeige FN1 Proteine) both in vitro as well as in vivo.
Integrin beta1 and dystroglycan compensate each other to mediate laminin-dependent basement membrane assembly and epiblast polarization.
The results of this study suggest that the effects of beta1-integrin gene knockout on these results suggest that the effects of beta1-integrin gene knockout on NSC maintenance and fate commitment in the DG follow a substantially slower time course in males compared to females because of increased persistence of beta1-integrin protein in males.
results suggest that Edil3 may stimulate osteoblast differentiation and matrix mineralization by increasing expression of Runx2 (zeige RUNX2 Proteine) through alpha5beta1 integrin /ERK (zeige EPHB2 Proteine) pathway
the cross-talk between SFRP4 (zeige SFRP4 Proteine), integrin alpha1beta1, and Notch1 (zeige NOTCH1 Proteine) suppresses the cardiac differentiation of P19CL6 cells.
Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism.
We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits it to PI3P-positive organelles, where RabGAP1L inactivates Rab22A, and promotes polarized trafficking to the leading edge of migrating fibroblasts. We further determine that a5b1-integrin depends on an AnkB/RabGAP1L complex for polarized recycling
Itgb1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of Sharpin-deficient mice.
Taken together, acid-induced acute lung injury results in epithelial microvesicle shuttling of miR-17/221 that in turn modulates macrophage beta1 integrin recycling, promoting macrophage recruitment and ultimately contributing to lung inflammation.
We demonstrate that ANGPT2 (zeige ANGPT2 Proteine) signaling activated after estrogen depletion paradoxically triggers ER+ tumor cell awakening from dormancy in their BM niche, partly indirectly via endothelial Tie2 (zeige TEK Proteine) receptor and partly directly via tumor cell surface integrin &1.
Our data suggest a previously unanticipated link between CAS (zeige CSE1L Proteine) and integrin beta1 signaling which correlates with an aggressive hepatocellular carcinoma phenotype.
Human pluripotent stem cells promote the expression of integrin alpha6beta1, and nuclear localization and inactivation of FAK (zeige PTK2 Proteine) to supports stem cell self-renewal.
ITGalpha4beta1 and TLR4 (zeige TLR4 Proteine) have roles in inducing fibrotic gene expression in response to fibronectin's EDA (zeige EDA Proteine) domain
focal adhesion kinase (FAK) transduces integrin activation and supports Human embryonic stem cell survival, substrate adhesion, and maintenance of the undifferentiated state.
Data show that the interaction of beta1 integrins with hERG1 (zeige KCNH2 Proteine) channels in cancer cells stimulated distinct signaling pathways that depended on the conformational state of hERG1 (zeige KCNH2 Proteine) and affected different aspects of tumor progression.
ANGPTL1 (zeige ANGPTL1 Proteine) inhibited angiogenesis by interacting with integrin alpha1beta1 receptor to suppress the downstreamJAK2-STAT3 (zeige STAT3 Proteine) signaling pathway.
Metastatic prostate cancer cells cultured on osteo-mimetic surfaces coated with tenascin C (zeige TNC Proteine) exhibited enhanced adhesion and colony formation as mediated by integrin alpha9beta1.
alpha5beta1 integrin can stimulate drug resistance in cancer cells via a mechanism based on inhibition of protein kinase (zeige CDK7 Proteine) Erk (zeige EPHB2 Proteine).
We measured the effect of recombinant Gal-3 (zeige LGALS3 Proteine) added exogenously on the lateral mobility of the alpha5b1 integrin on HeLa cells. Using single-particle tracking (SPT (zeige AGXT Proteine)) we detected increased lateral mobility of the integrin in the presence of Gal-3 (zeige LGALS3 Proteine), while its truncated C-terminal domain (Gal (zeige GAL Proteine)-3C) showed only minor reductions in lateral mobility.
beta1-integrin antigen-antibody interactions and the distribution of beta1-integrin protein on spermatogonial stem cell membrane were demonstrated using atomic force microscopy
The overall findings suggest that the secreted galectin-3 (zeige LGALS3 Proteine) stimulated by PGF (zeige PGF Proteine) plays a role in structural luteolysis by binding to beta 1 integrin.
Putative function of fibronectin (zeige FN1 Proteine) and its receptor (integrin alpha(5 (zeige ITGA5 Proteine))beta(1)) in male and female gametes during bovine fertilization in vitro.
integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myosin light chain diphosphorylation.
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
both the gpIb-VWF (zeige VWF Proteine) interaction and the integrin alpha(2 (zeige ITGA2 Proteine))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (zeige GSTA3 Proteine))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (zeige VWF Proteine) is bound
TRPV4 (zeige TRPV4 Proteine) channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
integrin beta 1
, integrin beta-1*
, integrin beta-1-B
, VLA-4 subunit beta
, fibronectin receptor subunit beta
, integrin beta-1
, beta OL
, beta oligodendroglia
, integrin VLA-4 subunit beta
, integrin beta 1 (fibronectin receptor beta)
, glycoprotein IIa
, integrin VLA-4 beta subunit
, very late activation protein, beta polypeptide
, integrin beta-1 subunit
, CSAT antigen
, JG22 antigen
, Fibronectin receptor subunit beta
, Integrin VLA-4 subunit beta
, Integrin subunit beta-1