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PAR3 is essential in thrombin (zeige F2 Proteine) stimulated insulin (zeige INS Proteine) secretion.
TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS (zeige NOS3 Proteine)-Thr (zeige TRH Proteine)-495 with minimal phosphorylation of eNOS (zeige NOS3 Proteine)-Ser (zeige SIGLEC1 Proteine)-1177 with no change in nitric oxide production.
These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR (zeige JTB Proteine) activation, such as the activation of vascular-protective Tie2 (zeige TEK Proteine) by noncanonical PAR3 activation.
In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin (zeige CDH1 Proteine), leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav.
Data indicate that knockdowns of all three PARs (zeige EPRS Proteine) PAR-1 (zeige MARK2 Proteine), PAR-2 (zeige F2RL1 Proteine), and PAR-3 exhibited changes in the expression of CDC42 (zeige CDC42 Proteine), which correlated with the changes in their invasion.
Elevated expression of PAR-3, b (zeige MARK2 Proteine)ut not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients.
A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C (zeige PROC Proteine) cytoprotective effects.
PAR-3 receptors interact with thrombin (zeige F2 Proteine) and increase heme oxygenase-1 (zeige HMOX1 Proteine) expression in synovial fibroblasts.
Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR (zeige ELAVL1 Proteine), whereas transcriptional control involves nuclear factor of activated T cells (NFAT (zeige NFATC1 Proteine)).
FXa (zeige F10 Proteine) bound in a punctate manner to thrombi under shear, while thrombin (zeige F2 Proteine) and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi
Data show that activated protein C (zeige PROC Proteine) signals via protease activated receptors PAR2 (zeige F2RL1 Proteine)/PAR3 to expand Treg cells, mitigating the disease in mice.
found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2 (zeige IQGAP2 Proteine)) and F2rl2
Simultaneous depletion of PAR-1 (zeige MARK2 Proteine) and PAR-3 almost completely inhibited epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.
these data point to a novel kallikrein 6 (zeige KLK1 Proteine) -signaling axis in neurons that is mediated by PAR1 (zeige F2R Proteine) and PAR2 (zeige F2RL1 Proteine) and is positioned to contribute to neurodegeneration
Par3(-/-) mice were protected against ferric chloride-induced thrombosis of mesenteric arterioles and against thromboplastin (zeige F3 Proteine)-induced pulmonary embolism (protease-activated receptor-3 (PAR3)
PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1 (zeige F2R Proteine)-type thrombin (zeige F2 Proteine) receptors
Crystal structures reveal the molecular basis of the cofactor function of cleaved PAR3, bound to exosite I, on recognition of PAR4 (zeige F2RL3 Proteine) by the active site of thrombin (zeige F2 Proteine).
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.
Coagulation factor II receptor-like 2 (protease-actovated receptor 3)
, protease-activated receptor 3
, proteinase-activated receptor 3
, proteinase-activated receptor-3
, thrombin receptor-like 2
, Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)
, coagulation factor II receptor-like 2
, coagulation factor II (thrombin) receptor-like 2 L homeolog