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EGF (zeige EGF Proteine) suppresses specifically CAR signaling mainly through transcriptional regulation and drives the xenobiotic response toward a pregnane X receptor (PXR (zeige NR1I2 Proteine))-mediated mechanism.
Membrane Dynamics and Signaling of the Coxsackievirus and Adenovirus Receptor.
Combining CAR activation with limited beta-catenin (zeige CTNNB1 Proteine) activation induces tumorigenesis, and the tumours share a conserved gene expression signature with beta-catenin (zeige CTNNB1 Proteine)-positive human hepatocellular carcinoma.
Subsequent experiments also proved that both the rno (zeige NLRP12 Proteine)-miR (zeige MLXIP Proteine)-466d and the human hsa (zeige CD24 Proteine)-miR (zeige MLXIP Proteine)-466, which are orthologs of the miR (zeige MLXIP Proteine)-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively
CAR regulates epithelial cell junction stability through control of E-cadherin (zeige CDH1 Proteine) trafficking.
CAR belongs to the increasing list of cell surface molecules that undergo ectodomain shedding and that are substrates for -secretase-mediated RIP.
CAR and ASIC3 (zeige ACCN3 Proteine) co-immunoprecipitate only when co-expressed with PSD-95 (zeige DLG4 Proteine).
In blastocysts, CAR was expressed at the cell contacts within the inner cell mass as well as in the trophectoderm (TE) where CAR was found together with ZO1 (zeige TJP1 Proteine) at the apical contacts, suggesting that CAR builds up apical TJs in TE and mediates cell adhesion in TE and inner cell mass. CAR was expressed in TE of implanting embryos as well as endometrial epithelium.
Coxsackievirus and Adenovirus Receptor and potentially an unidentified factor present in mouse serum might be important mediators of Human adenoviral serotype 5 transduction.
Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response
the intracellular domain of CAR differentially regulates AdV (zeige AVIL Proteine) entry and trafficking. Our study highlights the mechanistic differences that a receptor can have for two viruses from the same family.
Conclude that CXADR possesses no direct role in testicular physiology in vivo.
crystal structure of junctional adhesion molecule-like (zeige AMICA1 Proteine) protein (JAML (zeige AMICA1 Proteine)) and coxsackie and adenovirus receptor; data show how CAR-mediated clustering of JAML (zeige AMICA1 Proteine) recruits phosphoinositide 3-kinase to a JAML (zeige AMICA1 Proteine) intracellular sequence motif
Adoptive transfer of Tregs protected mice from coxsackievirus B3-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway.
Coxsackievirus and adenovirus receptor (CAR) is found in complex with the PDZ domain-containing protein (zeige USH1C Proteine) ligand-of-numb protein (zeige NUMBL Proteine)-X (LNX (zeige LNX1 Proteine))
The mCAR gene is situated on the distal portion of murine chromosome 16, and is composed of at least eight exons, with intron-exon boundaries similar to those reported for the human CAR gene
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.
46 kD coxsackievirus and adenovirus receptor (CAR) protein
, CVB3-binding protein
, coxsackievirus B-adenovirus receptor
, coxsackievirus and adenovirus receptor
, coxsackievirus and adenovirus receptor homolog
, adenovirus receptor
, coxsackie virus and adenovirus receptor
, coxsackievirus and adenovirus receptor-like