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EGF suppresses specifically CAR signaling mainly through transcriptional regulation and drives the xenobiotic response toward a pregnane X receptor (PXR)-mediated mechanism.
The results pf this study demonstrated that CAR is expressed by mature neurons throughout the brain. In addition, we propose divergent roles for CAR in immature neurons, during neurogenesis, and at the mature synapse.
data indicate that glycosylation of the extracellular CAR domain has only minor importance for the function of CAR as Coxsackievirus B3 (CVB3) receptor and that the D2 domain is not essential per se but contributes to receptor function by promoting the exposure of the D1 domain on the cell surface
CAR expression has potential as a marker for monitoring and/or predicting the outcome of gene therapy, and increasing its expression levels may contribute to the upregulation of cellular sensitivity towards adenovirus infection.
Membrane Dynamics and Signaling of the Coxsackievirus and Adenovirus Receptor.
Combining CAR activation with limited beta-catenin activation induces tumorigenesis, and the tumours share a conserved gene expression signature with beta-catenin-positive human hepatocellular carcinoma.
Glycan microarray, flow cytometry, surface plasmon resonance and ELISA analyses reveal that the terminal knob domain of the long fiber (52LFK) binds to CAR, and the knob domain of the short fiber (52SFK) binds to sialylated glycoproteins.
Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells.
Suggest that distinct forms of CAR play different roles in the undifferentiated state and tight junction formation of human embryos and embryonic stem cells.
CAR might play a role in adipose tissue dysfunction, given its dual associations with adipogenic and inflammatory genes.
Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively
This study shows for the first time that lovastatin reduces the expression of CAR and subsequently the replication of CVB3 in human umbilical vein endothelial cells.
CAR regulates epithelial cell junction stability through control of E-cadherin trafficking.
Kinetic analyses show that the apparent first-order rate constant for the inactivation of coxsackievirus B3 by soluble CAR (sCAR) at physiological temperatures varies nonlinearly with sCAR concentration.
CAR substantially impacts the growth and survival of oral squamous cell carcinoma cells as a negative regulator of ROCK in vitro and in vivo.
novel modifier of ventricular conduction and arrhythmia vulnerability in the setting of myocardial ischemia
CAR belongs to the increasing list of cell surface molecules that undergo ectodomain shedding and that are substrates for -secretase-mediated RIP.
The expression of CAR was detected in all normal organs, except in the brain. In malignancies, a high degree of variability was notable, ranging from significantly elevated CAR expression to decreased CAR expression.
CAR expression in tumor tissues was significantly higher than that in normal lung tissues. CAR expression had a correlation with the histological grade of lung squamous cell carcinoma.
CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95.
These results establish a requirement for CAR in the terminal differentiation of renal glomerular and tubular cell types.
In blastocysts, CAR was expressed at the cell contacts within the inner cell mass as well as in the trophectoderm (TE) where CAR was found together with ZO1 at the apical contacts, suggesting that CAR builds up apical TJs in TE and mediates cell adhesion in TE and inner cell mass. CAR was expressed in TE of implanting embryos as well as endometrial epithelium.
Coxsackievirus and Adenovirus Receptor and potentially an unidentified factor present in mouse serum might be important mediators of Human adenoviral serotype 5 transduction.
Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response
the intracellular domain of CAR differentially regulates AdV entry and trafficking. Our study highlights the mechanistic differences that a receptor can have for two viruses from the same family.
Conclude that CXADR possesses no direct role in testicular physiology in vivo.
with significant difference). At dpc 8.5, CAR expression was increased slightly again. It is concluded that during implantation, the expression of CAR mRNA and protein is declined, resulting in the impairment of tight junction.
These findings indicate that CAR plays an important role in the initiation of coxsackievirus B virus infections and is closely associated with hepatotropism and age-specific susceptibility.
CAR plays an essential role in development of the lymphatic vasculature in the mouse embryo by promoting appropriate formation of lymphatic endothelial cell-cell junctions.
CAR exerts important functions in the physiology of several organs in vivo
Data show for the first time that CAR upregulation in the adult mouse heart induces cardiac inflammation reminiscent of early viral myocarditis.
increased CAR expression has a role in inducing cardiomyopathy
crystal structure of junctional adhesion molecule-like protein (JAML) and coxsackie and adenovirus receptor; data show how CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase to a JAML intracellular sequence motif
Adoptive transfer of Tregs protected mice from coxsackievirus B3-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway.
Blocking antibodies were found to inhibit neurite extension in retina organ and retinal explant cultures, whereas the application of extracellular CAR domains promoted neurite extension and adhesion to extracellular matrices.
Review: Receptor for the group B coxsackieviruses and adenoviruses, CAR
Coxsackievirus and adenovirus receptor (CAR) is found in complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)
The mCAR gene is situated on the distal portion of murine chromosome 16, and is composed of at least eight exons, with intron-exon boundaries similar to those reported for the human CAR gene
CAR provides positive survival signals to cardiomyocytes that are essential for normal heart development.
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.
46 kD coxsackievirus and adenovirus receptor (CAR) protein
, CVB3-binding protein
, coxsackievirus B-adenovirus receptor
, coxsackievirus and adenovirus receptor
, coxsackievirus and adenovirus receptor homolog
, adenovirus receptor
, coxsackie virus and adenovirus receptor
, coxsackievirus and adenovirus receptor-like