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Human TFAP2A Protein expressed in Wheat germ - ABIN1322523
Zhang, Li, Shibahara, Takahashi: Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2alpha. in Peptides 2008
AP2a initiates neural border patterning and is sufficient to elicit a neural border-like pattern in neuralized (zeige NEURL Proteine) ectoderm.
Genetic interaction between tfap2a and mitfa suggest that the factors en (zeige MITF Proteine)coded by these genes regulate shared targets in melanocytes, possibly within single or converging pathways.
these data support a model in which Tfap2a, acting through Bmp7a (zeige BMP7 Proteine), modulates Fgf and Notch (zeige NOTCH1 Proteine) signaling to control the duration, amount and speed of SAG (zeige SAG Proteine) neural development.
Prdm1a directly binds and activates a tfap2a enhancer at the NPB
Low Bmp activates expression of the transcription factor Tfap2a as part of a gene regulatory network that coordinates development of neural crest, preplacodal ectoderm and individual placodes in zebrafish.
tfap2a and foxd3 (zeige FOXD3 Proteine) are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 (zeige FOXD3 Proteine) in the dorsal mesendoderm and ectoderm
These results reveal that mutations in TFAP2A are associated with a wide range of eye phenotypes and that hypomorphic tfap2a mutations can increase the risk of developmental defects arising from mutations at other loci.
These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e (zeige TFAP2E Proteine), promotes melanophore differentiation in parallel with Mitf (zeige MITF Proteine) by an effector other than Kit.
Results demonstrate that tfap2a is required for early steps in neural crest development and for the survival of a subset of neural crest derivatives.
data show that hindbrain noradrenergic neurons of the locus coeruleus and the posterior groups both require Tfap2a to establish their noradrenergic identity
Ap-2alpha regulates multiple steps of melanophore development, and is required for development of other neuronal and non-neuronal neural crest derivatives.
High-confidence AP2alpha (zeige AP2A1 Proteine)-binding peaks were detected in the regulatory regions of many target genes involved in the development of facial tissues including MSX1 (zeige MSX1 Proteine), IRF6 (zeige IRF6 Proteine), TBX22 (zeige TBX22 Proteine), and MAFB (zeige MAFB Proteine). In addition, we uncovered multiple single-nucleotide polymorphisms (SNPs) disrupting a conserved AP2alpha (zeige AP2A1 Proteine) consensus sequence.
We identified two SLN genes (PIGR and TFAP2A) that provided high prognostic accuracy in SLN-positive melanoma patients (AUC = 0.864). These two SLN genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients
We identified miR (zeige MLXIP Proteine)-1254 as a negative regulator inhibiting HO-1 (zeige HMOX1 Proteine) translation by directly targeting HO-1 (zeige HMOX1 Proteine) 3'UTR via its seed region, and suppressing HO-1 (zeige HMOX1 Proteine) transcription via non-seed region-dependent inhibition of transcriptional factor AP-2 alpha (TFAP2A), a transcriptional activator of HO-1 (zeige HMOX1 Proteine).
dimerization-defective mutant of Nef failed to interact with either CD4 (zeige CD4 Proteine) or AP-2 (zeige GTF3A Proteine) in the BiFC assay, indicating that Nef quaternary structure is required for CD4 (zeige CD4 Proteine) and AP-2 (zeige GTF3A Proteine) recruitment as well as CD4 (zeige CD4 Proteine) down-regulation
Data show that TFAP2A binds many of the same regulatory elements as MITF (zeige MITF Proteine) in melanocytes.
the atrial fibrillation (AF)-associated SNP rs2595104 altered PITX2c (zeige PITX2 Proteine) expression via interaction with TFAP2a; such a pathway could ultimately contribute to AF susceptibility at the PITX2 (zeige PITX2 Proteine) locus associated with AF
AP-2a is an important transcription factor of DEK (zeige DEK Proteine) expression, which is correlated with the methylation level of the DEK (zeige DEK Proteine) core promoter in hepatocellular carcinoma .
AP-2alpha expression has a role in human hepatocellular cancer by regulating signaling to affect cell growth and migration
Hepatitis B virus X protein is able to elevate the expression of SPHK1 (zeige SPHK1 Proteine) in hepatoma cells by upregulating transcription factor AP2 alpha.
Results indicate that AP-2alpha activates COX-2 expression to promote NPC (zeige NPC1 Proteine) growth.
RNA interference of transcriptional factor activator protein 2alpha (AP-2alpha) reversed the inhibitory effects of aspirin on atherosclerosis in Apoe (zeige APOE Proteine)-/- mice.
Study systematically examined the expression profile of AP-2 family in the developing mouse and chick spinal cord and found that AP-2alpha and AP-2beta (zeige TFAP2B Proteine) are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha and AP-2beta (zeige TFAP2B Proteine) have distinct functions in dorsal interneuron specification and differentiation.
MEX3C (zeige MEX3C Proteine) associates with the endolysosomal compartment through an endocytosis-like process. siRNA-mediated inhibition of the MEX3C (zeige MEX3C Proteine) or AP-2 complex (zeige AP2B1 Proteine) substantially decreased exosomal but not cellular microRNA miR (zeige MLXIP Proteine)-451a expression
High AP-2 alpha phosphorylation is associated with abdominal aortic aneurysm.
overexpression of Dnmt3a (zeige DNMT3A Proteine) partially rescued the impairment of adipogenesis induced by AP2alpha knockdown.
TFAP2A is a conserved component of the core network that regulates EMT, acting as a repressor of many genes, including ZEB2.
The AP-2beta (zeige TFAP2B Proteine) transcription factor is an important effector of PITX2 (zeige PITX2 Proteine) function during corneal development, required for differentiation of corneal endothelium and establishment of angiogenic privilege.
the regulation of synaptic-vesicle (SV) recycling via early endosomes by the interdependent regulation of AP-2-mediated endocytosis and AP-1 (zeige JUN Proteine)/sigma1B (zeige AP1S2 Proteine)-mediated SV reformation, is reported.
By gain-of function and loss-of-function approaches, ap2a and 2b were identified to be the major downstream targets of Ptf1a (zeige PTF1A Proteine) to specify the amacrine cell fate.
The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
, transcription factor AP-2 alpha
, AP-2 transcription factor
, transcription factor AP-2-alpha
, transcription factor AP-2
, Transcription factor AP-2 alpha
, adipocyte lipid-binding protein
, adipocyte-type fatty acid-binding protein
, fatty acid-binding protein 4
, fatty acid-binding protein, adipocyte
, activating enhancer-binding protein 2 alpha
, activating enhancer-binding protein 2-alpha
, activator protein 2
, mont blanc
, AP-2 alpha
, Ap-2 (a)