anti-Human SPTAN1 Antikörper für Enzyme Immunoassay

Recommended SPTAN1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Spectrin alpha Chain, Brain (SPTAN1) Antikörper
  • im:7157190
  • wu:fa20e05
  • wu:fb33g08
  • wu:fk32a10
  • zgc:112229
  • 2610027H02Rik
  • Spna-2
  • Spna2
  • EIEE5
  • NEAS
  • SPTA2
  • A2a
  • IPF
  • SPECA
  • spectrin alpha, non-erythrocytic 1
  • spectrin, alpha, non-erythrocytic 1
  • SPTAN1
  • sptan1
  • Sptan1
Reaktivität
Human
99
62
53
29
21
5
5
4
4
4
3
3
1
1
1
Wirt
Maus
137
26
Klonalität
Monoklonal
Konjugat
Dieser SPTAN1 Antikörper ist unkonjugiert
21
18
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
142
62
40
35
20
20
19
15
14
5
3
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN1109119
$ 643.50
Zzgl. Versandkosten $45.00

General

Antigen Spectrin alpha Chain, Brain (SPTAN1) Antikörper
Reaktivität Human
(99), (62), (53), (29), (21), (5), (5), (4), (4), (4), (3), (3), (1), (1), (1)
Wirt Maus
(137), (26)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser SPTAN1 Antikörper ist unkonjugiert
(21), (18), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(142), (62), (40), (35), (20), (20), (19), (15), (14), (5), (3), (1)
Pubmed 10 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-SPTAN1 Antikörper

Target Details SPTAN1 Anwendungsinformationen Handhabung Referenzen für anti-SPTAN1 Antikörper (ABIN1109119) Bilder
Spezifität The antibody clone AA6 is specific to the 240 kDa Alpha-Fodrin molecule of all Mammalian nonerythroid cells and Chicken Alpha-Spectrin.
Kreuzreaktivität (Details) Species reactivity (tested):Human, Rat, Chicken, Rabbit and Guinea Pig.
Reinigung Ig Fraction
Immunogen Chicken red blood cell membranes purified by hypotonic lysis and mechanical enucleation. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Klon AA6
Isotyp IgG1
Plasmids, Primers & others

Target Details SPTAN1

Produktdetails anti-SPTAN1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-SPTAN1 Antikörper (ABIN1109119) Bilder zurück nach oben
Antigen
Andere Bezeichnung Spectrin alpha Chain (Brain) / SPTAN1 (SPTAN1 Antibody Abstract)
Hintergrund Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.Synonyms: Alpha-II spectrin, Fodrin alpha chain, SPTA2, Spectrin non-erythroid alpha chain
Gen-ID 374234
NCBI Accession NP_001036003
UniProt P07751
Pathways Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization

Anwendungsinformationen

Produktdetails anti-SPTAN1 Antikörper Target Details SPTAN1 Handhabung Referenzen für anti-SPTAN1 Antikörper (ABIN1109119) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-SPTAN1 Antikörper Target Details SPTAN1 Anwendungsinformationen Referenzen für anti-SPTAN1 Antikörper (ABIN1109119) Bilder zurück nach oben
Konzentration 0.1 mg/mL
Buffer PBS, 0.09 % Sodium Azide, 1.0 % BSA
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C.

Referenzen für anti-SPTAN1 Antikörper (ABIN1109119)

Produktdetails anti-SPTAN1 Antikörper Target Details SPTAN1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Sormunen, Leong, Vääräniemi, Fernando, Eskelinen: "Immunolocalization of the fodrin, E-cadherin, and beta-catenin adhesion complex in infiltrating ductal carcinoma of the breast-comparison with an in vitro model." in: The Journal of pathology, Vol. 187, Issue 4, pp. 416-23, 1999

McClintock, Rising, Lerner: "Melanophore pigment dispersion responses to agonists show two patterns of sensitivity to inhibitors of cAMP-dependent protein kinase and protein kinase C." in: Journal of cellular physiology, Vol. 167, Issue 1, pp. 1-7, 1996

Tuominen, Sormunen, Kallioinen: "Non-erythroid spectrin (fodrin) in cutaneous tumours: diminished in cell membranes, increased in the cytoplasm." in: The British journal of dermatology, Vol. 135, Issue 4, pp. 576-80, 1996

Wigler, Patterson: "Reversal agent inhibition of the multidrug resistance pump in human leukemic lymphoblasts." in: Biochimica et biophysica acta, Vol. 1189, Issue 1, pp. 1-6, 1994

Sormunen, Pääkkö, Palovuori, Soini, Lehto: "Fodrin and actin in the normal, metaplastic, and dysplastic respiratory epithelium and in lung carcinoma." in: American journal of respiratory cell and molecular biology, Vol. 11, Issue 1, pp. 75-84, 1994

Sormunen: "Alpha-spectrin in detergent-extracted whole-mount cytoskeletons of chicken embryo heart fibroblasts." in: The Histochemical journal, Vol. 25, Issue 9, pp. 678-86, 1993

Sormunen, Eskelinen, Lehto: "Bile canaliculus formation in cultured HEPG2 cells." in: Laboratory investigation, a journal of technical methods and pathology, Vol. 68, Issue 6, pp. 652-62, 1993

Reima, Lehtonen, Virtanen, Fléchon: "The cytoskeleton and associated proteins during cleavage, compaction and blastocyst differentiation in the pig." in: Differentiation, research in biological diversity, Vol. 54, Issue 1, pp. 35-45, 1993

Eskelinen, Huotari, Sormunen, Palovuori, Kok, Lehto: "Low intracellular pH induces redistribution of fodrin and instabilization of lateral walls in MDCK cells." in: Journal of cellular physiology, Vol. 150, Issue 1, pp. 122-33, 1992

Huotari, Sormunen, Lehto, Eskelinen: "Different organizational states of fodrin in cultured MDCK cells are induced by treatment with low pH, calmodulin antagonist TFP, and tumor promoter PMA." in: Journal of cellular physiology, Vol. 153, Issue 2, pp. 340-52, 1992