anti-Ratte (Rattus) NUMA1 Antikörper für ELISA

Recommended NUMA1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antikörper
  • NUMA
  • 6720401E04Rik
  • AA764025
  • AL022610
  • AU014979
  • NUMA1
  • NuMA
  • SP-H
  • numa
  • numa1
  • nuclear mitotic apparatus protein 1
  • nuclear mitotic apparatus protein 1 S homeolog
  • NUMA1
  • Numa1
  • numa1
  • numa1.S
Epitop
pSer1225
16
7
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
131
34
28
3
3
2
2
1
1
1
1
1
1
1
1
Wirt
Kaninchen
86
46
Klonalität
Polyklonal
Konjugat
Dieser NUMA1 Antikörper ist unkonjugiert
4
4
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
66
48
35
33
32
26
26
22
13
9
4
2
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN6270194
$ 450.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2917851 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1089545 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN5872763 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN802652 IHC ELISA Rabbit Anmelden zum Anzeigen Polyclonal 0

General

Antigen Nuclear Mitotic Apparatus Protein 1 (NUMA1) Antikörper
Epitop pSer1225
(16), (7), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(131), (34), (28), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Wirt Kaninchen
(86), (46)
Klonalität
Polyklonal
Konjugat Dieser NUMA1 Antikörper ist unkonjugiert
(4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(66), (48), (35), (33), (32), (26), (26), (22), (13), (9), (4), (2), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-NUMA1 Antikörper

Target Details NUMA1 Anwendungsinformationen Handhabung Bilder
Spezifität Phospho-NuMA (Ser1225) Antibody detects endogenous levels of NuMA only when phosphorylated at Ser1225
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human NuMA around the phosphorylation site of Ser1225
Isotyp IgG
Plasmids, Primers & others

Target Details NUMA1

Produktdetails anti-NUMA1 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung NuMA (NUMA1 Antibody Abstract)
Hintergrund

Description: Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity).

Gene: NUMA1

Molekulargewicht 240kDa
Gen-ID 4926
UniProt Q14980
Pathways Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, M Phase

Anwendungsinformationen

Produktdetails anti-NUMA1 Antikörper Target Details NUMA1 Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:500-1:2000, IHC 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-NUMA1 Antikörper Target Details NUMA1 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months