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Human Polyclonal NUMA1 Primary Antibody für ICC, IF - ABIN152988
Gaglio, Saredi, Compton: NuMA is required for the organization of microtubules into aster-like mitotic arrays. in The Journal of cell biology 1995
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Human Monoclonal NUMA1 Primary Antibody für IHC (fro), IHC (p) - ABIN966706
Compton, Szilak, Cleveland: Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. in The Journal of cell biology 1992
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Human Polyclonal NUMA1 Primary Antibody für ICC, IF - ABIN261713
Yan, Li, Wang, Hong, Zhang, Yang, Lin, Zhang, He, Zheng, Tang, Yin, Shao: The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells. in The Journal of cell biology 2015
Cow (Bovine) Polyclonal NUMA1 Primary Antibody für WB - ABIN2784222
Kilpivaara, Rantanen, Tamminen, Aittomäki, Blomqvist, Nevanlinna: Comprehensive analysis of NuMA variation in breast cancer. in BMC cancer 2008
Here, the authors use quantitative imaging and laser ablation to show that NuMA targets dynactin to spindle microtubule minus-ends, localizing dynein activity there.
All urine samples were analyzed by voided urine and bladder washing cytology, NMP22 and UBC (zeige RPS27A Antikörper) rapid test (qualitatively and quantitatively). The best cutoff (highest Youden index; >/=6.7 ng/ml) for the quantitative UBC (zeige RPS27A Antikörper) was determined by receiver operating characteristic curves.
Short isoform of NuMA might be functioned as a putative role of tumor suppressor. Further studies should be made to illuminate the relationship between ACTN4 (zeige ACTN4 Antikörper), MYBL2 (zeige MYBL2 Antikörper), and tumor progression.
The function of nuclear mitotic apparatus protein (NuMA) in rDNA transcription and p53 (zeige TP53 Antikörper)-independent nucleolar stress response suggests a central role for NuMA in cellular homeostasis.
Importin-alpha/-beta regulates the NuMA functioning required for assembly of higher-order microtubule structures including the mitotic spindle.
Low post translational modifications of NuMA protein is associated with neoplasms.
Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. Both exons 15 and 16 in long NuMA were "hotspot" for alternative splicing. Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls.
Chimeric proteins constructed by fusion of LANA of Kaposi's sarcoma-associated herpesvirus with the NuMA could bind with ori-P and enhance replication of an ori-P-containing plasmid.
findings reveal a direct physical link between two important regulators of mitotic progression and demonstrate the critical role of the NuMA-Astrin (zeige SPAG5 Antikörper) interaction for accurate cell division.
Aurora-A (zeige AURKA Antikörper) governs the dynamic exchange between the cytoplasmic and the spindle pole-localized pools of NuMA. Aurora-A (zeige AURKA Antikörper) phosphorylates directly the C terminus of NuMA on three Ser (zeige SIGLEC1 Antikörper) residues, of which Ser1969 determines the dynamic behavior and the spindle orientation functions of NuMA.
These results reveal an additional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative use of spindle orientation in the skin to build diverse structures.
Suppressor APC domain containing 2 negatively regulates the localization of LGN (zeige GPSM2 Antikörper) at the cell cortex, likely by competing with NuMA for its binding
Loss of 4.1/NuMA interaction results in spindle orientation defects and inhibition of Cdk1 (zeige CDK1 Antikörper) causes increase in cortical NuMA localization
ectopic expression of BRAP2 (zeige BRAP Antikörper) inhibits nuclear localization of HMG20A (zeige HMG20A Antikörper) and NuMA1, and prevents nuclear envelope accumulation of SYNE2 (zeige SYNE2 Antikörper).
Fusion protein NuMA-RARalpha (zeige RARA Antikörper) cooperates with RXRalpha (zeige RXRA Antikörper) in the development of leukemia in hCG (zeige CGA Antikörper)-NuMA-RARalpha (zeige RARA Antikörper) transgenic mice.
Thus, NuMA is a defining feature of the mammalian spindle pole and functions as an essential tether linking bulk microtubules of the spindle to centrosomes.
Inhibiting Crm1 (zeige XPO1 Antikörper) in early metaphase causes the formation of excess acentriolar spindle poles containing NuMA and B23 (zeige NPM1 Antikörper), but does not affect centrosome numbers.
The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 (zeige JUN Antikörper) DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
MCAK (zeige KIF2C Antikörper) colocalized with NuMA and XMAP215 (zeige CKAP5 Antikörper) at the center of Ran asters where its activity is regulated by Aurora A (zeige AURKA Antikörper)-dependent phosphorylation of S196, which contributes to proper pole focusing
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
, centrophilin stabilizes mitotic spindle in mitotic cells
, structural nuclear protein
, nuclear mitotic apparatus protein 1
, nuclear mitotic apparatus protein 1-like
, nuclear mitotic apparatus protein 1 S homeolog
, nuclear/mitotic apparatus protein