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Human APP ELISA Kit für Sandwich ELISA - ABIN921082
Turner, OConnor, Tate, Abraham: Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. in Progress in neurobiology 2003
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Human APP ELISA Kit für Sandwich ELISA - ABIN414520
Shi, Wu, Xu, Zou: Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. in Neurochemistry international 2011
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Rat (Rattus) APP ELISA Kit für Sandwich ELISA - ABIN579070
Grolla, Fakhfouri, Balzaretti, Marcello, Gardoni, Canonico, DiLuca, Genazzani, Lim: Aβ leads to Ca²⁺ signaling alterations and transcriptional changes in glial cells. in Neurobiology of aging 2012
Mouse (Murine) APP ELISA Kit - ABIN1882413
Zhang, Hu, Teng, Tang, Chen: Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Human APP ELISA Kit - ABIN1882410
Qosa, Abuasal, Romero, Weksler, Couraud, Keller, Kaddoumi: Differences in amyloid-? clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling. in Neuropharmacology 2014
Rat (Rattus) APP ELISA Kit für Sandwich ELISA - ABIN810848
Tian, Guo, Yue, Lv, Ye, Wang, Chen, Wu, Xu, Liu: Intranasal administration of nerve growth factor ameliorate ?-amyloid deposition after traumatic brain injury in rats. in Brain research 2012
In Alzheimer's Disease brain, amyloid Beta-protein binds to synapses and requires the expression of amyloid precursor protein to disrupt synaptic activity.
activation of mTOR (zeige FRAP1 ELISA Kits) signalling via RHEB (zeige RHEB ELISA Kits) over-expression inhibited the starvation-induced autophagy but did not affect trafficking of tf-Amyloid precursor protein (APP). These results show tf-APP can be used to determine how APP is trafficked through the lysosomal system of the cell.
Study found that FERMT2 (zeige FERMT2 ELISA Kits) (a beta3-integrin (zeige ITGB3 ELISA Kits) co-activator) was significantly associated with a variation in cerebrospinal fluid Abeta peptide levels in 2886 Alzheimer's disease cases.Under-expression of FERMT2 (zeige FERMT2 ELISA Kits) increases Abeta peptide production by raising levels of mature APP at the cell surface and facilitating its recycling
a 99-aa C-terminal fragment of APP,C99, in addition to its localization in endosomes, can also be found in mitochondria-associated endoplasmic reticulum (ER) membranes, where it is normally processed rapidly by gamma-secretase.
Photoinduced electrons of g-C3 N4 generate reactive oxygen resulting in photooxidation of amyloid peptides that blocks Abeta aggregation.
Studies indicate that amyloid precursor-like protein 2 (APLP2 (zeige APLP2 ELISA Kits)) and amyloid precursor protein (APP) are linked to increased tumor cell proliferation, migration, and invasion.
the precise and complex regulation of APP phosphorylation, abundance, and cleavage impacts the generation of nuclear spheres, which are under discussion of being of relevance in neurodegeneration and dementia.
Decreased lipoprotein endocytosis and transcytosis of APP to the axon suggest that a neuron-specific impairment in endocytic axonal delivery of lipoproteins and other key materials might compromise synaptic maintenance in familial Alzheimer's disease.
Our results suggested that hAPP was more likely an important factor inhibiting adult neurogenesis, and Abeta was not the major factor affecting neurogenesis in the adult hippocampus of hAPP mice.
the AOEP2 peptide binds to Abeta monomers and inhibits the formation of Abeta oligomers and beta-sheet structure, reduces Abeta42-induced neurotoxicity, and decreases the release of proinflammatory cytokines.
Results show that Drosophila APPL-RNAi largely mimics transgenic amyloid beta in various phenotypes which include eye degeneration, reduced longevity and motor neuron deficit functions. This is the first report showing comparable phenotypes between APPL and amyloid beta in Alzheimer's disease model of Drosophila.
Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate (zeige GRIN2A ELISA Kits) recycling.
memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.
Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.
findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease
APPL is the first example of a modulator of the Wnt (zeige WNT4 ELISA Kits)-PCP (zeige PRCP ELISA Kits) pathway specifically required for axon outgrowth.
Data show that Appl is directly regulated by the Ras/MAPK (zeige MAPK1 ELISA Kits) pathway through a mechanism mediated by PntP2 (zeige ETS2 ELISA Kits).
[review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.
Disruption of amyloid protein (zeige IAPP ELISA Kits) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.
Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (zeige ABCA2 ELISA Kits)) reduces amyloid-beta production by altering Nicastrin (zeige NCSTN ELISA Kits) maturation and intracellular localization.
This study describes Abeta deposition in 102 clinically characterized cattle brains from animals aged 0 to 20 years, demonstrates certain similarities between Abeta deposition patterns exhibited in cattle brains and those in the human brain in early stages of aging
release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1
Amyloid-beta inhibits No-cGMP signaling in a CD36 (zeige CD36 ELISA Kits)- and CD47 (zeige CD47 ELISA Kits)-dependent manner
These experiments demonstrate the roles of Chol and ApoE (zeige APOE ELISA Kits) in the modulation of membrane insertion of APP.
Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.
APP could be acting through a semaphorin receptor as well
The authors concluded that the FcgammaRIIb-SHIP2 (zeige INPPL1 ELISA Kits) axis links Abeta neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
results suggest that PrP(C (zeige PRNP ELISA Kits)) recognizes structural features common to both Abeta oligomers and fibril ends and that this interaction could contribute to the neurotoxic effect of Abeta aggregates.
Our study provides the first direct evidence that Abeta, an AD-linked factor, is associated to the pathogenesis of ALS and provides molecular clues to understand common aggregation mechanisms in the pathogenesis of neurodegenerative diseases.
Although hyperactivity and hypersynchronicity were respectively detected in mice expressing the PS2 (zeige PDCD6 ELISA Kits)-N141I or the APP Swedish mutant alone, the increase in cross-frequency coupling specifically characterized the 6-month-old PS2APP mice, just before the surge of the cognitive decline
these results uncover a novel role for mDia1 in Abeta-mediated synaptotoxicity and demonstrate that inhibition of MT dynamics and accumulation of PTMs are driving factors for the induction of tau-mediated neuronal damage.
APP and its metabolites are capable of influencing the basic physiology of the pancreas.
treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4
These results provide evidence supporting a key role for the p38 MAPK (zeige MAPK14 ELISA Kits) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 (zeige LRP1 ELISA Kits) in vivo.
increased APP and/or beta-CTF (zeige NFIA ELISA Kits) impact the endocytic pathway to disrupt NGF (zeige NGFB ELISA Kits) trafficking and signaling, resulting in trophic deficits in basal forebrain cholinergic neurons.
Amyloid beta precursor protein and prion protein (zeige PRNP ELISA Kits) have a conserved interaction affecting cell adhesion and central nervous system development.
A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.
these results indicate the Appa-RFP (zeige MKRN1 ELISA Kits) and Aplp2 (zeige APLP2 ELISA Kits) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.
Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (zeige PSEN1 ELISA Kits)), does not.
Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.
A "CAGA (zeige S100A8 ELISA Kits)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.
endogenous cleavages at prohormone convertase-like sites in APP
amyloid and oxidative stress-related disease proteins like Alzheimer A beta (zeige SUCLA2 ELISA Kits) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.
study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (zeige IGF1 ELISA Kits) signaling
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
alzheimer disease amyloid protein
, amyloid beta A4 protein
, beta-amyloid peptide
, cerebral vascular amyloid peptide
, peptidase nexin-II
, protease nexin-II
, amyloid protein
, alzheimer disease amyloid A4 protein homolog
, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
, Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4)
, amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease)
, amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease)
, beta-amyloid precursor protein
, amyloid precursor protein
, amyloid precursor protein-like
, amyloid A4
, amyloidogenic glycoprotein
, protease nexin II
, amyloid beta precursor protein a
, beta-amyloid precursor protein A