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genetic alterations in RPH3AL are associated with aggressive behavior of breast cancers and with short survival of patients.
Noc2 may function as a Rab3B (zeige RAB3B Proteine) effector protein in epithelial cells.
These results suggest that the dual effector, Noc2, regulates the transition from Rab2a (zeige RAB2A Proteine)-mediated granule biogenesis to Rab27a (zeige RAB27A Proteine)-mediated granule exocytosis.
In pancreatic acinar cells, Noc2 is not indispensable for the membrane fusion of ZG per se, but instead performs a novel function favoring agonist-induced physiological [Ca(2 (zeige CA2 Proteine)+)](i) increases.
Results show that Noc2, a critical effector of Rab3 (zeige RAB3A Proteine), is essential in normal regulation of exocytosis in both endocrine and exocrine cells.
investigated localization of Noc2 immunohistochemically in various endocrine and exocrine tissues in normal mice, including pancreatic islets, the adrenal gland, pituitary gland, salivary gland, and thyroid gland
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
no C2 domains protein
, rab effector Noc2
, rabphilin-3A-like protein