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Cow (Bovine) Polyclonal NOX4 Primary Antibody für ICC, IHC (fro) - ABIN189715
Maranchie, Zhan: Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. in Cancer research 2005
Show all 49 Pubmed References
Human Polyclonal NOX4 Primary Antibody für FACS, ICC - ABIN4340462
Weyemi, Caillou, Talbot, Ameziane-El-Hassani, Lacroix, Lagent-Chevallier, Al Ghuzlan, Roos, Bidart, Virion, Schlumberger, Dupuy: Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues. in Endocrine-related cancer 2010
Show all 37 Pubmed References
Human Polyclonal NOX4 Primary Antibody für IF (p), IHC (p) - ABIN702610
Kashiwabara, Ambe, Nakagawa, Watanabe: Immunohistochemical localization of Nox in mouse circumvallate papillae. in Tissue & cell 2015
Dog (Canine) Polyclonal NOX4 Primary Antibody für IF (p), IHC (p) - ABIN737526
Khan, Byer, Khan: Exposure of Madin-Darby canine kidney (MDCK) cells to oxalate and calcium oxalate crystals activates nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase. in Urology 2014
Human Polyclonal NOX4 Primary Antibody für IHC, IHC (p) - ABIN409683
Zhang, Liu, Hu: Inhibiting cancer metastasis via targeting NAPDH oxidase 4. in Biochemical pharmacology 2013
Nox4 not only mediated TGF-beta1 (zeige TGFB1 Antikörper)- induced collagen type I synthesis but also the expression of the myofibroblast markers alpha-SMA (zeige SMN1 Antikörper) and fibronectin 1 (zeige FN1 Antikörper).
High NOX4 expression is associated with drug resistance in renal cell carcinoma (zeige MOK Antikörper).
Nox4 potentially mediates HGinduced HKC cell apoptosis.
Our results showed that lowering NOX4 oxidase below physiological level leads to cellular senescence of vascular smooth muscle cells
Extracellular advanced oxidative protein products accumulation triggered NOX4-dependent reactive oxygen species production, which activated ERK1/2 and p38 MAPK (zeige MAPK14 Antikörper), and induced HaCaT cell apoptosis by activating caspase 3 (zeige CASP3 Antikörper) and PARP-1 (zeige PARP1 Antikörper).
The results establish a link between BRAF (zeige BRAF Antikörper)(V600E) and NOX4, which is confirmed by a comparative analysis of NOX4 expression in human (TCGA) and mouse thyroid cancers.
This study also showed that UCH-L1 (zeige UCHL1 Antikörper) promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS (zeige ROS1 Antikörper) by deubiquitination of NOX4, suggesting that UCH-L1 (zeige UCHL1 Antikörper) plays a key role in angiogenesis of HUVECS by regulating ROS (zeige ROS1 Antikörper) levels by deubiquitination of NOX4.
The results reveal that NOX4 promotes glycolysis, contributing to non-small cell lung cancer cells growth, and supports glutaminolysis for oxidative resistance.
Metformin attenuates idiopathic lung fibrosis development via suppression of myofibroblast NOX4 expression.
Letter: airway smooth muscle cell NOX4 expression is increased in vivo and in vitro in COPD (zeige ARCN1 Antikörper).
Strong dityrosine formation was observed, but was significantly weaker in NOX4-/- mice (p<0.05). NOX2 (zeige CYBB Antikörper), HIF1alpha (zeige HIF1A Antikörper) and CD31 (zeige PECAM1 Antikörper) expression was significantly weaker in NOX4-/- mice (p<0.05). In this study we show for the first time that NOX4 plays a role in cutaneous wound repair.
These results indicated that carnosic acid (CA)attenuated oxidative stress via inhibition of Nox4 expression in TGF-beta (zeige TGFB1 Antikörper)-stimulated fibroblasts and UUO operated-kidneys, suggesting that CA may be useful for the treatment of fibrosis-related diseases
Spinal cord injury leads to a significant increase in NOX4 expression.
NOX4 actively regulates smooth muscle cells (SMC (zeige DYM Antikörper)) pathophysiological responses in diabetic Apoe (zeige APOE Antikörper)(-/-) mice and in primary mouse SMCs through the activities of PDGF (zeige PDGFA Antikörper) and NOX1 (zeige NOX1 Antikörper).
we used the Ang II (zeige AGT Antikörper) infused hph-1 (zeige EGLN2 Antikörper) mice to examine the roles of NOX isoforms in the development of AAA (zeige AAAS Antikörper). We generated double mutants of hph-1 (zeige EGLN2 Antikörper)-NOX1 (zeige NOX1 Antikörper), hph-1 (zeige EGLN2 Antikörper)-NOX2 (zeige CYBB Antikörper), hph-1 (zeige EGLN2 Antikörper)-p47phox, and hph-1 (zeige EGLN2 Antikörper)-NOX4
The major reactive oxygen species (ROS (zeige ROS1 Antikörper)) source in brain, NADPH oxidase (zeige NOX1 Antikörper) subunit 4 increased in hypoxia but not in hyperoxia, whereas neither affected nuclear factor (erythroid-derived 2)-like 2 (zeige NFE2L2 Antikörper), a transcription factor that regulates the expression of antioxidant proteins
Nox4 has no influence on lifespan of healthy mice.
MFA has a protective effect on alcohol-induced liver injury, which may be related to its antioxidant,anti-inflammatory,lipid-eliminating properties and its ability to regulate the NOX4/ROS (zeige ROS1 Antikörper)-MAPK (zeige MAPK1 Antikörper) signalling pathway.
Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.
MRTF down-regulation/inhibition suppresses TGFbeta (zeige TGFB1 Antikörper)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.
Nox4 NADPH oxidase (zeige NOX1 Antikörper) mediates oxidative stress and apoptosis caused by TNF-alpha (zeige TNF Antikörper) in cerebral vascular endothelial cells.
Nox4 NADPH oxidase (zeige NOX1 Antikörper)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (zeige HMOX2 Antikörper).
proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (zeige NOX1 Antikörper) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (zeige P4HB Antikörper) mRNA expression
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
, kidney superoxide-producing NADPH oxidase
, renal NAD(P)H-oxidase
, superoxide-generating NADPH oxidase 4
, NADPH oxidase 4
, predicted NADPH oxidase-4