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General |
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Antigen | Carboxypeptidase B2 (Plasma) (CPB2) Antikörper |
Epitop | AA 126-156 Alternativen |
Reaktivität | Human Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Unkonjugiert Alternativen |
Applikation |
Enzyme Immunoassay (EIA), Western Blotting (WB)
Alternativen
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1 Publikation vorhanden |
Hersteller | Anmelden zum Anzeigen |
ProduktdetailsAntigendetails Anwendungsinformationen Handhabung Referenzen Bilder |
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Spezifität | This antibody detects CPB2 (aa 126~156). |
Kreuzreaktivität (Details) | Species reactivity (tested):Human, |
Reinigung | Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Immunogen | KLH conjugated synthetic peptide selected between 126~156 amino acids from the Center region of Human CPB2 |
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Antigen | |
Andere Bezeichnung | Carboxypeptidase B2 (CPB2 Antibody Abstract) |
Hintergrund | Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for its gene and its promoter region.Synonyms: CPB2, CPU, Carboxypeptidase U, Plasma carboxypeptidase B, TAFI, Thrombin-activable fibrinolysis inhibitor, pCPB |
Molekulargewicht | 48412 Da |
Gen-ID | 1361 |
NCBI Accession | NP_001863 |
UniProt | Q96IY4 |
Pathways | Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis |
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Applikationshinweise |
ELISA: 1/1,000. Western blot: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | 0.25 mg/mL |
Buffer | PBS with 0.09 % (W/V) Sodium Azide as preservative. |
Konservierungsmittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freezing and thawing. |
Lagerung | 4 °C/-20 °C |
Informationen zur Lagerung | Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. |
ReferenzenProduktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Allgemeine Veröffentlichungen |
Valnickova, Thogersen, Christensen, Chu, Pizzo, Enghild: "Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12937-43, 1996 |
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Bilder des Herstellers |