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Ca(v)2.3 Ca2 (zeige CA2 Antikörper)+ channel interacts with the G1-subunit of V-ATPase (zeige ATP6V1H Antikörper).
This study identified a polymorphism in exon 20 of the CACNA1E gene (Asp859Glu - rs35737760) that is more prevalent in hemiplegic and brain stem aura (zeige AURKA Antikörper) migraine.
Data suggest that, in vascular smooth muscle cells, increase in cytosolic endothelin-1 (EDN1 (zeige EDN1 Antikörper)) induces sustained increase in nuclear Ca2 (zeige CA2 Antikörper)+ via stimulation of R-type calcium channel (CACNA1E) present at the nuclear membrane.
CACNA1E gene single nucleotide polymorphisms may be involved in fentanyl sensitivity.
The C-terminus of human Ca(v)2.3 voltage-gated calcium channel interacts with alternatively spliced calmodulin-2 expressed in two human cell lines
quartet of leucine residues in the guanylate kinase (zeige GUK1 Antikörper) domain of CaVbeta determines the plasma membrane density of the CaV2.3 channel.
CACNA1E variants affect beta cell function in patients with newly diagnosed type 2 diabetes.
the II-III loop of the Ca(v)2.3 calcium channel binds APLP1 (zeige APLP1 Antikörper) and that this binding promotes internalization of the channel
Lack of high-voltage activated Cav2.3 channels results in a marked decrease in the sensitivity of transgenic animals to gamma-butyrolactone-induced absence epilepsy.
Swapping the I-II intracellular linker between L-type CaV1.2 (zeige CACNA1C Antikörper) and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes.
The results of this study showed that Cav2.3 is a novel mechanistic target for a key pronociceptive miRNA, miR (zeige MLXIP Antikörper)-34c-5p.
Data show that apamin boosts evoked excitatory postsynaptic potentials (EPSPs) in CaV2.3 R-Type Ca2 (zeige CA2 Antikörper)+ Channel knockout (CaV2.3-/-) mice.
under conditions of Zn2+ deficiency, ablation or dysfunction of Cav2.3 channels may lead to severe disturbances in glucose homeostasis.
Cav2.1 (zeige CACNA1A Antikörper)-2.3 have unique contributions to the dynamics at the Schaffer collateral synapse that are engaged by the complex patterns of afferent activity seen in vivo
Low-voltage activated CaV2.3 R-type Ca(2 (zeige CA2 Antikörper)+) channels in the thalamocortical loop and extra-thalamocortical circuitries substantially regulate rodent sleep architecture and represent a novel potential target for pharmacological treatment of sleep disorders
Cacna1e expression (and Cacna1h (zeige CACNA1H Antikörper)) is essential for paraventricular hypothalamic neuronal activity and preventing hyperphagia.
Cav2.3 does not only contribute to the cardiac autonomous nervous system but also to intrinsic rhythm propagation.
Cav2.3 voltage-gated divalent calcium channels (VGCC) are an important factor in septohippocampal synchronization associated with theta; oscillation.
stimulation with exogenous PACAP (zeige ADCYAP1 Antikörper) and native neuronal stress stimulation both lead to a PKC (zeige PKC Antikörper)-mediated phosphodependent recruitment of a T-type Ca(v)3.2 Ca(2 (zeige CA2 Antikörper)+) influx, which in turn evokes catecholamine release during the acute sympathetic stress response
Both high-affinity Ni(2 (zeige VMP1 Antikörper)+)-sensitive Ca(2 (zeige CA2 Antikörper)+) channels contribute to transretinal signalling.
Inhibition of CaV2.3 channels by NK1 (zeige B3GAT1 Antikörper) receptors is sensitive to membrane cholesterol but insensitive to caveolin-1 (zeige CAV1 Antikörper).
Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
voltage-dependent R-type calcium channel subunit alpha-1E
, voltage-gated calcium channel alpha 1E subunit
, calcium channel, voltage-dependent, R type, alpha 1E subunit
, brain calcium channel II
, calcium channel, L type, alpha-1 polypeptide
, calcium channel, R type, alpha-1 polypeptide
, calcium channel, voltage-dependent, alpha 1E subunit
, voltage-dependent calcium channel alpha 1E subunit
, voltage-gated calcium channel alpha subunit Cav2.3
, voltage-gated calcium channel subunit alpha Cav2.3
, calcium channel, voltage-dependent, L type, alpha 1E subunit
, voltage gated calcium channel alpha1E subunit
, voltage-dependent calcium channel alpha1-E subunit
, brain calcium channel BII-1
, brain calcium channel BII-2