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anti-Mouse (Murine) Antikörper:
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Rat (Rattus) Polyclonal AGER Primary Antibody für FACS, IF (p) - ABIN725900
Huang, Yao, Zhang, Dong, Yu, Sheng: The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats. in Shock (Augusta, Ga.) 2009
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Human Polyclonal AGER Primary Antibody für IHC (fro), IHC (p) - ABIN3044329
Qin, Niu, Wang, Xu, Qiao, Gu: Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway. in Cardiovascular diabetology 2013
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Human Polyclonal AGER Primary Antibody für IHC (p), WB - ABIN3043529
Wang, Zhang, Liu, Cui, Yang, Li, Du: Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. in Brain research 2010
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Human Polyclonal AGER Primary Antibody für IHC (p), WB - ABIN548553
Taguchi, Blood, del Toro, Canet, Lee, Qu, Tanji, Lu, Lalla, Fu, Hofmann, Kislinger, Ingram, Lu, Tanaka, Hori, Ogawa, Stern, Schmidt: Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. in Nature 2000
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Human Polyclonal AGER Primary Antibody für IF (p), IHC (p) - ABIN1386239
Durning, Preston-Hurlburt, Clark, Xu, Herold: The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus. in Journal of immunology (Baltimore, Md. : 1950) 2016
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Rat (Rattus) Polyclonal AGER Primary Antibody für FACS, IF (p) - ABIN725907
Zhu, Yao, Zhang, Dong, Yu, Sheng: Anti-RAGE antibody ameliorates severe thermal injury in rats through regulating cellular immune function. in Acta pharmacologica Sinica 2014
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Human Polyclonal AGER Primary Antibody für ELISA, WB - ABIN1573995
Milutinovic, Alcorn, Englert, Crum, Oury: The receptor for advanced glycation end products is a central mediator of asthma pathogenesis. in The American journal of pathology 2012
Human Polyclonal AGER Primary Antibody für IHC (p), WB - ABIN1397268
Guan, Sheu, Wu, Chiang, Liu: ATP synthase subunit-β down-regulation aggravates diabetic nephropathy. in Scientific reports 2015
Cow (Bovine) Polyclonal AGER Primary Antibody für WB - ABIN2786877
Luo, Saiardi, Nagata, Ye, Yu, Jung, Luo, Jain, Sawa, Snyder: GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. in Neuron 2001
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Decreased soluble RAGE in neutrophilic asthma is correlated with disease severity and RAGE G82S variants.
Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer.
Plasmatic RAGE level is significantly lower in patients with prosthetic-joint-associated infections.
Inhibition of GLO1 (zeige GLO1 Antikörper) in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models
a significant association between RAGE gene rs1800624 and rs1800625 polymorphisms and Age-related macular degeneration risk, is reported.
HMGB1 (zeige HMGB1 Antikörper) mediates fibroblast activity via RAGE-MAPK (zeige MAPK1 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) signaling in keloid scar formation.
Data revealed that hESC accumulates CML (zeige BCR Antikörper) and RAGE under oxidative stress conditions in different ways than somatic cells, being the accumulation of CML (zeige BCR Antikörper) statistically significant only in somatic cells and, conversely, the RAGE increase exclusively appreciated in hESC.
In women with Polycystic ovary syndrome(PCOS), the low ovarian levels of the anti-inflammatory sRAGE suggest that sRAGE could represent a biomarker and a potential therapeutic target for ovarian dysfunction in PCOS. Whether there is a direct causal relationship between sRAGE and vit (zeige VIT Antikörper) D in the ovaries remains to be determined
current research highlighted the Glo-I/AGE/RAGE system as an interesting therapeutic target in chronic liver diseases. These findings need further elucidation in preclinical and clinical studies.
Our findings suggested that polymorphisms in the RAGE gene are involved in genetic susceptibility to Alzheimer disease but did not modify the risk of lewy body disease.
Chronic unpredictable stress (CUS) promotes significant morphological changes and causes robust upregulation of HMGB1 (zeige HMGB1 Antikörper) messenger RNA in enriched hippocampal microglia and robust and persistent upregulation of RAGE messenger RNA. CUS increased surface expression of RAGE protein on hippocampal microglia and anhedonic behavior. RAGE knockout mice were resilient to stress-induced anhedonia.
study found that diabetes predisposes to more severe infections because of additional inflammatory output through dual activation of MyD88 (zeige MYD88 Antikörper) by not only TLR4 (zeige TLR4 Antikörper) but also RAGE
RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway.
these data provide a previously uncharacterized in vivo mechanism contingent on oligodeoxy-nucleotide -administered dose, where TLR9 (zeige TLR9 Antikörper) governs the primary response and RAGE plays a distinct and cooperative function in providing a pivotal role in balancing the immune response.
data demonstrate that under the diabetic condition, DRG neurons are directly affected by elevated levels of glucose, independent of vascular or glial signals, and dependent on RAGE expression.
findings suggest that HMGB1 (zeige HMGB1 Antikörper) induces the transcytosis of albumin (zeige ALB Antikörper) via RAGE-dependent Src (zeige SRC Antikörper) phosphorylation and Cav-1 (zeige CAV1 Antikörper) phosphorylation. These studies revealed a new mechanism of HMGB1 (zeige HMGB1 Antikörper)-induced endothelial hyperpermeability.
data suggest that S100A8 (zeige S100A8 Antikörper)/A9 acts directly on BV-2 microglial cells via binding to TLR4 (zeige TLR4 Antikörper) and RAGE on the membrane and then stimulates the secretion of proinflammatory cytokines through ERK (zeige EPHB2 Antikörper) and JNK (zeige MAPK8 Antikörper)-mediated NF-kappaB (zeige NFKB1 Antikörper) activity in BV-2 microglial cells.
Activation of RAGE facilitates the development of hypoxia-induced pulmonary hypertension by increasing ECM (zeige MMRN1 Antikörper) deposition in pulmonary arteries.
knockout of RAGE significantly ameliorates mainstream cigarette smoke-induced airway inflammation in mice
Here, the authors show that RAGE deficiency impairs anti-viral immunity during an early-life infection with pneumonia virus of mice (PVM; a murine analogue of RSV). The elevated viral load was associated with the release of high mobility group box-1 (HMGB1 (zeige HMGB1 Antikörper)) which triggered airway smooth muscle remodelling in early-life.
Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan (zeige ACAN Antikörper) content in nucleus pulposus.
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
RAGE isoform NtRAGE-delta
, RAGE isoform sRAGE-delta
, advanced glycation end-products receptor
, receptor for advanced glycosylation end products
, advanced glycosylation end product-specific receptor variant 2
, advanced glycosylation end product-specific receptor variant 3
, advanced glycosylation end product-specific receptor variant 4
, advanced glycosylation end product-specific receptor variant 5
, advanced glycosylation end product-specific receptor variant 1
, advanced glycosylation end product-specific receptor variant 6
, advanced glycosylation end product-specific receptor variant 7
, advanced glycosylation end product-specific receptor variant 8
, advanced glycation end product receptor
, advanced glycosylation end product-specific receptor
, MAPK/MAK/MRK overlapping kinase
, renal tumor antigen