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results provide evidence that PGI2/IP signaling suppresses the STAT6 (zeige STAT6 Proteine)-independent pathway of allergic airway inflammation
Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (Ptgir) is involved in insulin (zeige INS Proteine) secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin (zeige NPHS1 Proteine).
Deletion of the I prostanoid receptor had no effect on the attenuation of atherogenesis by mPGES-1 (zeige PTGES Proteine) deletion in the low-density lipoprotein receptor (zeige LDLR Proteine) knockout mice.
Prostacyclin promotes the up-regulation of Nox4 (zeige NOX4 Proteine) in endothelial cells, which opens up a novel strategy that protects and enhances endothelial cell functions in cardiovascular disease, such as repair after myocardial infarction or other ischemic conditions.
Its signaling increase cAMP concentration, which prototes sysnesis of HGF (zeige HGF Proteine), causing angiogenesis.
an essential role of the COX-2/PGI2 receptor axis in the cardioprotection afforded by the late ischemic preconditioning
findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target
PGI2-induced PPAR delta (zeige PPARD Proteine) activation accelerates blastocyst hatching in mice
For the first time these results show that activation of prostaglandin I2 receptor can attenuate damage following cerebral ischemia.
identify PGI(2)-prostaglandin I2 receptor as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4 (zeige CD4 Proteine)(+) Th2 cells into the inflammatory site
these studies are not only the first to identify alpha4 helix of Rab11a as a protein binding domain on the GTPase but also reveal novel mechanistic insights into the intracellular trafficking of the human prostacyclin receptor (hIP), and potentially of other members of the GPCR superfamily, involving Rab11-dependent mechanisms.
role of IP-PPARdelta (zeige PPARD Proteine) signal transduction pathway in the production of sAPPalpha in cerebral microvasculature.
Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (PTGIR) is involved in insulin (zeige INS Proteine) secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin (zeige NPHS1 Proteine).
The human prostacyclin receptor gene is under the transcriptional regulation of dihydrotestosterone, where this regulation is further influenced by serum-cholesterol levels.
these findings suggest that reduced IPR expression in DM2 (zeige CNBP Proteine) platelets may contribute to platelet hyperactivity in humans with type 2 diabetes.
Prostaglandin I2- Prostaglandin I2 receptor signaling regulates human Th17 and Treg cell differentiation.
these data provide critical insights into the transcriptional regulation of the human prostacyclin receptor gene within the vasculature, including during megakaryocytic differentiation
IP receptor heteridimerization with thromboxane receptor (zeige TBXA2R Proteine) facilitates receptor trafficking to membrane lipid rafts.
Prostacyclin receptor-dependent inhibition of human erythroleukemia cell differentiation is STAT3 (zeige STAT3 Proteine)-dependent
IKEPP (zeige PDZD3 Proteine) was also found to be expressed in vascular endothelial cells where it co-localizes and complexes with the hIP
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.
, PGI2 receptor
, prostacyclin receptor
, prostaglandin I2 receptor
, prostanoid IP receptor
, prostaglandin I receptor (IP)