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anti-Human PDE7A Antikörper:
anti-Mouse (Murine) PDE7A Antikörper:
anti-Rat (Rattus) PDE7A Antikörper:
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Human Polyclonal PDE7A Primary Antibody für CM, ICC - ABIN2747196
Ong, Gribble, Reimann, Lynch, Houslay, Baillie, Furman, Pyne: The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release. in British journal of pharmacology 2009
Show all 2 Pubmed References
Human Polyclonal PDE7A Primary Antibody für ELISA, WB - ABIN562151
Bazhin, Kahnert, Kimpfler, Schadendorf, Umansky: Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells. in Molecular immunology 2010
Here we describe a compound, BC54, that is a selective inhibitor of enzymes from the cAMP-specific PDE4 (zeige PDE4A Antikörper) and PDE7 families. Consistent with the biological effect of other PDE4 (zeige PDE4A Antikörper) and PDE7 inhibitors, BC54 displays potent anti-inflammatory properties and is superior to a combination of rolipram (a PDE4 (zeige PDE4A Antikörper) inhibitor) and BRL50481 (a PDE7A inhibitor) for inducing apoptosis in chronic lymphocytic leukemia (CLL) cells
Low PDE7A expression is associated with sepsis.
PDE7A is a high-speed and low-affinity phosphodiesterase for cCMP.
Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells; PDE7A was expressed in neutrophils and alveolar macrophages
crystal structure of PDE7A1 catalytic domain complexed with the inhibitor 3 (zeige PPP1R11 Antikörper)-isobutyl-1-methylxanthine & kinetic analysis on mutant PDE7A1 and PDE4D2; results show several residues must work together to switch inhibitor selectivity between PDE4 (zeige PDE4A Antikörper) & PDE7
PDE7A is not essential for activation of T lymphocytes; its inactivation by targeted gene disruption appears to enhance in vivo humoral immune responses.
results demonstrate that PDE7A might regulate TNF-alpha (zeige TNF Antikörper) production in keratinocytes in a cAMP-dependent fashion
PDE7A is involved in regulation of cell proliferation and cytokine production of NKT (zeige CTSL1 Antikörper) cells.
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
, phosphodiesterase isozyme 7
, rolipram-insensitive phosphodiesterase type 7
, high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
, phosphodiesterase 7A
, high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A-like