Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human Neurofibromin 1 Antikörper:
anti-Rat (Rattus) Neurofibromin 1 Antikörper:
anti-Mouse (Murine) Neurofibromin 1 Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal Neurofibromin 1 Primary Antibody für ICC, IHC (fro) - ABIN152500
Kuorilehto, Ekholm, Nissinen, Hietaniemi, Hiltunen, Paavolainen, Penttinen, Peltonen: NF1 gene expression in mouse fracture healing and in experimental rat pseudarthrosis. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006
Show all 4 Pubmed References
Monoclonal Neurofibromin 1 Primary Antibody für IHC (fro), IP - ABIN534031
Reed, Gutmann: Tumorigenesis in neurofibromatosis: new insights and potential therapies. in Trends in molecular medicine 2001
Show all 3 Pubmed References
Guinea Pig Monoclonal Neurofibromin 1 Primary Antibody für IHC (p), IP - ABIN152499
Hisaoka, Hashimoto, Ohguri, Aoki, Okamoto, Tanaka, Okimoto, Nakamura, Ishida: Congenital (infantile) pseudarthrosis of the fibula associated with osteofibrous dysplasia. in Skeletal radiology 2004
Show all 3 Pubmed References
Monoclonal Neurofibromin 1 Primary Antibody für IP, ELISA - ABIN534030
Zhu, Parada: Neurofibromin, a tumor suppressor in the nervous system. in Experimental cell research 2001
Show all 2 Pubmed References
Guinea Pig Monoclonal Neurofibromin 1 Primary Antibody für IHC (p), IP - ABIN152498
Tucker, Riccardi, Brown, Fee, Sutcliffe, Vielkind, Wechsler, Wolkenstein, Friedman: S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas. in Journal of neuroscience research 2011
Findings indicate neurofibromin 1 (NF1) as the most frequently occurring driver mutation in mucosal melanoma, and RAS alterations, consisting of NRAS (zeige NRAS Antikörper) and KRAS mutations, were the second most frequent mutation type.
Mutation in NF1 gene is associated with mucosal melanoma.
Results show that the NF1 protein negatively regulates Ccl5 (zeige CCL5 Antikörper) expression through suppression of AKT (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling.
The fusion transcript codes for a protein in which the last 114 amino acids of SETD2 (zeige SETD2 Antikörper), i.e., the entire Set2 (zeige SETD2 Antikörper) Rpb1 (zeige POLR2A Antikörper) interacting (SRI (zeige SRI Antikörper)) domain of SETD2 (zeige SETD2 Antikörper), are replaced by 30 amino acids encoded by the NF1 sequence.
this studies show the ability of miR (zeige MLXIP Antikörper)-10b to activate the expression of c-Jun (zeige JUN Antikörper) through RhoC (zeige RHOC Antikörper) and NF1, which represents a novel pathway for promoting migration and invasion of human cancer cells
This study identifies a novel cohort of non-small cell lung cancer defined by NF1 mutation and suggests that ongoing therapeutic targeting strategies for KRAS tumors may also have efficacy in this population.
3 patients with urachal adenocarcinoma had neurofibromin 1 (NF1) mutations
the human nonsense NF1(Arg681*) and missense NF1(Gly848Arg) mutations have different effects on neurofibromin expression in the mouse and each recapitulates unique aspects of the NF1 phenotype.
the NF1 phenotype and genotype were similar between children with and without Moyamoya syndrome (MMS). Interestingly, three children experienced tumors with malignant histology or behavior. The presence of two first cousins in our cohort suggested that there may be potential genetic factors, not linked to NF1, with an additional role respect of NF1 might play a role in MMS pathogenesis
the NF1-mutated subtype of melanoma had a higher mutational burden and strongest ultraviolet rays mutation signature.
Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.
The N-terminal region of NF1 mediates the interaction with Fak56 and is required for the signaling activity and presynaptic localization of NF1
These results identify dAlk as an upstream activator of dNf1-regulated Ras signaling responsible for several dNf1 defects, and they implicate human Alk as a potential therapeutic target in NF1
memory-related functions of Rut (zeige ADCY5 Antikörper)-AC are both Nf1-dependent and -independent, that Nf1 mediates the formation of two distinct memory components within a single neuron population.
survival of a subset of midline glia cells depends upon direct suppression of the proapoptotic protein HID via the EGF receptor (zeige EGFR Antikörper)/RAS/MAPK (zeige MAPK1 Antikörper) pathway
role in insulin (zeige INS Antikörper)-mediated proliferation of Schneider cells
preliminary crystallographic characterization of a novel segment (homologous to the yeast Sec14p lipid exchange protein) from the neurofibromatosis type 1 protein
Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras
Loss of NF1 can give rise to non-cell-autonomous developmental defects, implicate aberrant Ras-mediated signaling in larval neurons as the primary cause of the NF1 growth deficiency.
Neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS (zeige ROS1 Antikörper) production, and NF1 may be treatable using catalytic antioxidants.
DNA variants in the NF1 gene are associated with genetic disposition to bovine spongiform encephalopathy.
The authors demonstrate in zebrafish that nf1 loss leads to aberrant activation of RAS (zeige RAB1A Antikörper) signaling in MYCN (zeige MYCN Antikörper)-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (zeige ARHGEF16 Antikörper) in nf1-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 mutant embryos.
study shows negative regulation of Ras (zeige RAB1A Antikörper) pathway through GAP activity of NF1 limits oligodendrocyte progenitor cell (OPC) proliferation and motility during development; provides insight into oncogenic mechanisms by which NF1 loss contributes to glial tumors
identification and characterization of nf1a and nf1b, orthologues of NF1, that show neural crest and cardiovascular defects resulting from morpholino knockdown, including vascular and cardiac valvular abnormalities
Low NF1 expression is associated with optic gliomagenesis.
these findings suggest that disrupting 5-HT6 (zeige HTR6 Antikörper) receptor-neurofibromin interaction prevents agonist-independent 5-HT6 (zeige HTR6 Antikörper) receptor-operated cAMP signaling in prefrontal cortex, an effect that might underlie neuronal abnormalities in NF1 patients.
Neurofibromin regulates macrophage superoxide production via p21Ras.Neurofibromin-deficient smooth muscle cells are sensitive to oxidative stress.NADPH oxidase 2 is required for NF1 arterial stenosis.Neurofibromatosis type 1 patients have evidence of chronic oxidative stress.
A major Ras regulator, neurofibromin 1 (NF1), is a direct effector of G-protein-coupled receptors signaling via Gbetagamma subunits in the striatum. Binding of Gbetagamma to NF1 inhibits its ability to inactivate Ras-regulated kinase pathways. Deletion of NF1 in striatal neurons prevents the opioid-receptor-induced activation of Ras and eliminates its coupling to Akt (zeige AKT1 Antikörper)-mTOR (zeige FRAP1 Antikörper)-signaling pathway.
NF1 germline mutation is associated with optic gliomas.
Notch (zeige NOTCH1 Antikörper) is an Nf1 effector.
Spatially- and temporally-controlled postnatal p53 (zeige TP53 Antikörper) knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation.
These findings demonstrate a role for Ras-GAP (zeige RASA1 Antikörper) activity in suppressing the hemogenic potential of the heart and restricting growth of neural crest-derived tissues.
identified p21Ras-dependent hyperphosphorylation of Pu.1 within the nucleus of Nf1 haploinsufficient myelomonocytic osteoclast precursors, providing a novel therapeutic target for the potential treatment of NF1 associated osteolytic manifestations.
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
neurofibromatosis-related protein NF-1
, Neurofibromatosis type 1
, neurofibromatosis 1
, neurofibromatosis factor 1
, neurofibromatosis type 1
, neurofibromin 1
, neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)