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anti-Human MC2R Antikörper:
anti-Mouse (Murine) MC2R Antikörper:
anti-Rat (Rattus) MC2R Antikörper:
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Human Polyclonal MC2R Primary Antibody für ELISA, WB - ABIN408678
Kilianova, Basora, Kilian, Payet, Gallo-Payet: Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. in Endocrinology 2006
Human Polyclonal MC2R Primary Antibody für FACS, IHC (p) - ABIN651731
Roy, Perron, Gallo-Payet: Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells. in Endocrinology 2010
Show all 2 Pubmed References
Results show regulation of melanocortin receptors MC2R, MC3R (zeige MC3R Antikörper) and MC4R (zeige MC4R Antikörper) gene expressions in CD8 (zeige CD8A Antikörper)(+) cytotoxic T-lymphocytes and CD19 (zeige CD19 Antikörper)(+) B lymphocytes in rheumatoid arthritis (RA) treated with tumor necrosis factor-alpha (TNF-alpha (zeige TNF Antikörper)) inhibitor (zeige ZFP36 Antikörper) adalimumab.
Four rare missense variants were identified (ACTBL2 (zeige ACTBL2 Antikörper) rs73757391 (5q11.2), BTD (zeige BTD Antikörper) rs200337373 (3p25.1), KRT13 (zeige KRT13 Antikörper) rs150321809 (17q21.2) and MC2R rs104894658 (18p11.21)), but only MC2R rs104894668 had a large effect size (OR = 9.66).
melanocortin receptors MC2R, MC3R (zeige MC3R Antikörper) and MC5R (zeige MC5R Antikörper) are most abundantly expressed in glandular epithelium of the endometrium
MC2R and MC1R (zeige MSHR Antikörper) signals are consecutively required for the regulation of EPO (zeige EPO Antikörper) signal transduction in erythroblast differentiation, and MC5R (zeige MC5R Antikörper) signal transduction is required to induce enucleation.
the MC2R gene may contribute to the development of intracerebral hemorrhage.
The A allele at rs1941088 in the MC2R gene, which encodes the adrenocorticotropic hormone (corticotropin, ACTH) receptor, is associated with a low cortisol response in critically ill children.
results suggest that Phe(7) in ACTH (zeige POMC Antikörper) plays an important role in ligand selectivity and that the third transmembrane domain of MC2R is crucial for ACTH (zeige POMC Antikörper) selectivity and potency
MC2R overexpression is associated with myelolipomas.
The patient with familial glucocorticoid deficiency was found to be homozygous for a novel mutation in the melanocortin-2 receptor gene (635insC, I154H).
Our observations suggest that MC2R is involved in prostate carcinogenesis and that targeting MC2R signaling may provide a novel avenue in prostate carcinoma treatment.
JDP2 (zeige JDP2 Antikörper) acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 (zeige JDP2 Antikörper) may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands.
Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice.
MC2R plays an important role for regular lipolytic function and lipid composition in 3T3-L1 adipocytes.
melanocortin 2 receptor and melanocortin 5 receptor (zeige MC5R Antikörper) are lipolytic mediators in differentiated 3T3-L1 adipocytes
MC2R+/- pups delivered from MC2R-/- females crossed with MC2R+/+ males mice thrived poorly with MC2R-/- mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R-/- females are poor mothers or cannot nurse.
The promoter activity of Mc2r is activated by FOXL2 (zeige FOXL2 Antikörper) in a dose-dependent manner; transcriptional activity of Mc2r is up-regulated by synergistic interaction of FOXL2 (zeige FOXL2 Antikörper) and NR5A1 (zeige NR5A1 Antikörper).
Data show that melanocortins regulate Il6 (zeige IL6 Antikörper) gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.
MC2R in Y1 cells internalizes by a G protein coupled receptor (zeige GPR34 Antikörper) kinase dependent clathrin-coated pit (zeige IRF6 Antikörper) mechanism.
Data show that adrenocorticotrophic hormone resistance in tumor cell mutants is associated with a base change polymorphism in the steroidogenic factor 1 (zeige NR5A1 Antikörper) gene.
Novel 135-bp exon 1f of ACTH-R gene was located 1.4 kb downstream in genome of exon 1a transcribed in adrenal gland. Promoter region flanking to exon 1f may be essential for adipose tissue; that flanking to exon 1a is specific for the adrenal gland.
zfMC2R is not functional in the absence of MRAP expression.
Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: MC2R (melanocortin 2 receptor); StAR (steroidogenic acute regulatory protein (zeige STAR Antikörper)); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.
Rainbow trout melanocortin-2 receptor structure and function analysis.
ACTH (zeige POMC Antikörper) regulation of MC2R is highly conserved in vertebrates.
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
, MC2 receptor
, adrenocorticotropic hormone receptor
, adrenocorticotropin receptor
, corticotropin receptor
, melanocortin receptor 2
, melanocortin 2 receptor
, melanocortin 2-receptor
, adrenal ACTH receptor
, G-protein-coupled receptor
, melanocortin 2 receptor-like
, putative melanocortin 2 receptor
, Adrenocorticotropin receptor
, Melanocortin receptor 2
, melanocortin 2 receptor (adrenocorticotropic hormone receptor)