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anti-Human GALR3 Antikörper:
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Human Polyclonal GALR3 Primary Antibody für IHC (p), IHC - ABIN251332
Swanson, Blackburn, Zhang, Zheng, Xu, Hökfelt, Wolinsky, Konkel, Chen, Zhong, Walker, Craig, Gerald, Branchek: Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. in Proceedings of the National Academy of Sciences of the United States of America 2005
Study showed that galanin receptor 3 is present in endothelial cells in human and murine dermal vessels and is co-expressed with nestin in neo-vessels of psoriatic patients.
GAL and its receptor GALR3 are differentially methylated and expressed in brains of major depressive disorder subjects in a region- and sex-specific manner.
Data from ligand-receptor interaction studies suggest that human spexin-1 and zebrafish spexin-2 activate galanin receptors GALR2/GALR3 (but not GALR1); thus spexins appear to be natural ligands for human/Xenopus/zebrafish GALR2/GALR3.
Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
The results suggest that GalR3, a receptor for the neuroendocrine peptide galanin, is a potential marker for relapsing pituitary tumors.
Mutated human GalR3 receptors are tested with competitive binding analysis in vitro, identifying six different sites in GalR3 that determine binding to galanin.
Elevated expression of galanin receptors in childhood neuroblastic tumors.
GALR3 showed a significant association with alcoholism that was driven by one SNP (rs3,091,367).
In a murine psoriasis model C57/BL6 mice lacking galanin receptor 3 display a milder course of psoriasis upon imiquimod treatment, leading to decreased disease severity, delayed neo-vascularization, reduced infiltration of neutrophils, and significantly lower levels of proinflammatory cytokines compared with wild-type mice.
does not influence oxazolone-induced contact dermatitis
After arthritis induction, GAL3 knockouts demonstrated increased clinical disease severity and earlier hindlimb edema than wild types.
Our data suggest involvement of GAL3 receptors in GAL-mediated effects on mood, anxiety, and behavior.
This study shows GalR3-mediated neuroprotection, supporting a potential future therapeutic development, based on GalR3 activation, for the treatment of brain disorders
Data show that galanin receptor mRNA and protein are expressed in mouse pancreas, with GALR3 mRNA predominating.
GalR3 is the receptor subtype mediating galanin's effects on the dermal microvasculature
Receptor for the hormone galanin.
galanin receptor type 3
, galanin receptor 3
, galanin receptor, family member 3