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anti-Rat (Rattus) GABBR2 Antikörper:
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Mammalian Monoclonal GABBR2 Primary Antibody für ISt, IHC - ABIN1304652
Workman, Haddick, Bush, Dilly, Niere, Zemelman, Raab-Graham: Rapid antidepressants stimulate the decoupling of GABA(B) receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η. in Molecular psychiatry 2015
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Mammalian Monoclonal GABBR2 Primary Antibody für ISt, IHC - ABIN1304653
Fernández-Alacid, Aguado, Ciruela, Martín, Colón, Cabañero, Gassmann, Watanabe, Shigemoto, Wickman, Bettler, Sánchez-Prieto, Luján: Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. in Journal of neurochemistry 2009
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Rat (Rattus) Polyclonal GABBR2 Primary Antibody für IF, WB - ABIN361471
Kuramoto, Wilkins, Fairfax, Revilla-Sanchez, Terunuma, Tamaki, Iemata, Warren, Couve, Calver, Horvath, Freeman, Carling, Huang, Gonzales, Cooper, Smart, Pangalos, Moss: Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. in Neuron 2007
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Human Monoclonal GABBR2 Primary Antibody für ICC, IHC - ABIN1724937
Balasubramanian, Fam, Hall: GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function. in The Journal of biological chemistry 2007
Chicken Polyclonal GABBR2 Primary Antibody für IF, WB - ABIN2473737
Roudier, Krause, Fierer, Guiney: Correlation between the presence of sequences homologous to the vir region of Salmonella dublin plasmid pSDL2 and the virulence of twenty-two Salmonella serotypes in mice. in Infection and immunity 1990
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There was no statistically significant association for the two SNPs of the GABBR1 (zeige GABBR1 Antikörper) gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 gene.
Missense Mutation in GABBR2 gene is associated with Neurodevelopmental Disorders.
GABBR2 is a genetic factor that determines Rett syndrome- or epileptic encephalopathy-like phenotype expression depending on the variant positions. GABBR2-mediated gamma-aminobutyric acid signaling is a crucial factor in determining the severity and nature of neurodevelopmental phenotypes.
a GABBR2 variant, predicted to be disease-causative, was significantly associated with corticospinal excitability at corrected levels. A subsequent uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 (zeige GABRA2 Antikörper) and DRD2 (zeige DRD2 Antikörper) variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset.
The rare variants in GABBR2 were significantly associated with smoking status.
GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2 (zeige CA2 Antikörper)+)]i via a Gi/o-coupled receptor pathway and a phospholipase C (zeige PLC Antikörper) activation pathway.
Putative GABAA (zeige GABRg1 Antikörper) and ASIC1a (zeige ACCN2 Antikörper) channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.
gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase (zeige DNAH8 Antikörper) Rtp6 and regulated by neuronal activity
and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities.
The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system.
Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma (zeige PRKCG Antikörper) but decreased that of GABABR1 (zeige GABBR1 Antikörper) and GABABR2 at both protein and mRNA levels in the CNC
GABABR2 has a role as a regulator of glutamine synthetase (zeige GLUL Antikörper) stability
siRNA knock-down of NgR1 (zeige NEUROG1 Antikörper) resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1 (zeige KCNJ3 Antikörper).
Cadm1 (zeige CADM1 Antikörper) specifically interacts with Mupp1 (zeige MPDZ Antikörper), and may form a ternary complex with Mupp1 (zeige MPDZ Antikörper)-GABBR2 in the cerebellum.
Gabbr1 (zeige GABBR1 Antikörper) and Gabbr2 transcription levels were altered in cerebral areas related to drug taking only in mice behaviorally classified as "addicted" drinkers
GABA(B)R is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 (zeige BMP2 Antikörper) expression toward disturbance of osteoclastogenesis after down-regulation of RANKL (zeige TNFSF11 Antikörper) expression in mouse bone.
results suggest that GABA(B)R2 protein levels are closely correlated with the partner subunit GABA(B)R1 (zeige GABBR1 Antikörper) protein levels in mouse brains during postnatal development in vivo
Our data suggest that association of GABAB(2) with GABAB(1 (zeige GABBR1 Antikörper)) is essential for receptor localization in distal processes but not absolutely necessary for signaling. Functional GABAB receptors may exist in neurons that naturally lack GABAB(2) subunits.
Activation of GABA(B) receptor by either GABA or the selective agonist baclofen induces ERK(1 (zeige MAPK3 Antikörper)/2) phosphorylation in cultured cerebellar granule neurons.
GABABR2 are expressed in the cerebellar cortex, supporting previous studies showing that inhibitory neurotransmission is highly patterned in the cerebellar cortex.
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
gamma-aminobutyric acid (GABA) B receptor, 2
, gamma-aminobutyric acid type B receptor subunit 2-like
, G protein-coupled receptor 51
, G-protein coupled receptor 51
, GABA-B R2 receptor
, GABA-B receptor 2
, gamma-aminobutyric acid type B receptor subunit 2
, GABA-B receptor, R2 subunit
, gamma-aminobutyric acid B receptor 2
, gamma-aminobutyric acid type B receptor, subunit 2
, ortholog of human G protein-coupled receptor 51 GPR51