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anti-Rat (Rattus) GABBR2 Antikörper:
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Mammalian Monoclonal GABBR2 Primary Antibody für ISt, IHC - ABIN1304652
Workman, Haddick, Bush, Dilly, Niere, Zemelman, Raab-Graham: Rapid antidepressants stimulate the decoupling of GABA(B) receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η. in Molecular psychiatry 2015
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Mammalian Monoclonal GABBR2 Primary Antibody für ISt, IHC - ABIN1304653
Fernández-Alacid, Aguado, Ciruela, Martín, Colón, Cabañero, Gassmann, Watanabe, Shigemoto, Wickman, Bettler, Sánchez-Prieto, Luján: Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. in Journal of neurochemistry 2009
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Human Monoclonal GABBR2 Primary Antibody für ICC, IHC - ABIN1724937
Balasubramanian, Fam, Hall: GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function. in The Journal of biological chemistry 2007
Rat (Rattus) Polyclonal GABBR2 Primary Antibody für IF, WB - ABIN361471
Kuramoto, Wilkins, Fairfax, Revilla-Sanchez, Terunuma, Tamaki, Iemata, Warren, Couve, Calver, Horvath, Freeman, Carling, Huang, Gonzales, Cooper, Smart, Pangalos, Moss: Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. in Neuron 2007
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Human Polyclonal GABBR2 Primary Antibody für WB - ABIN6140885
Zhou, Chen, Liu, Manyande, Zhang, Yang, Xiong, Fu, Song, Rittner, Ye, Tian: The Role of Spinal GABAB Receptors in Cancer-Induced Bone Pain in Rats. in The journal of pain : official journal of the American Pain Society 2018
GABA B receptor expression in myometrium
We demonstrated that GABBR2 gene might be a novel potential epigenetic treatment target with induction erlotinib treatment for stage IIIa (N2) EGFR 19 deletion lung adenocarcinoma
There was no statistically significant association for the two SNPs of the GABBR1 gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 gene.
Missense Mutation in GABBR2 gene is associated with Neurodevelopmental Disorders.
GABBR2 is a genetic factor that determines Rett syndrome- or epileptic encephalopathy-like phenotype expression depending on the variant positions. GABBR2-mediated gamma-aminobutyric acid signaling is a crucial factor in determining the severity and nature of neurodevelopmental phenotypes.
Using a ligand-guided approach, eight GABAB2 homology models have been chosen as possible structural representatives of the transmembrane domain of the GABAB2 subunit.
a GABBR2 variant, predicted to be disease-causative, was significantly associated with corticospinal excitability at corrected levels. A subsequent uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 and DRD2 variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset.
The rare variants in GABBR2 were significantly associated with smoking status.
GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2+)]i via a Gi/o-coupled receptor pathway and a phospholipase C activation pathway.
Putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.
The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation.
gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity
and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities.
Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA.
The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system.
The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 and GABBR2 genes.
Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit.
The results of this study provided evidence of Gabbr2 Deficit in schizophrenia and mood disorders.
GABA(B) receptor subunit 2 levels are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls.
variants of GABBR1 and GABBR2 are associated with nicotine dependence in European- and African-American populations
Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 and GABABR2 at both protein and mRNA levels in the CNC
GABABR2 has a role as a regulator of glutamine synthetase stability
siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1.
Cadm1 specifically interacts with Mupp1, and may form a ternary complex with Mupp1-GABBR2 in the cerebellum.
Gabbr1 and Gabbr2 transcription levels were altered in cerebral areas related to drug taking only in mice behaviorally classified as "addicted" drinkers
GABA(B)R is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 expression toward disturbance of osteoclastogenesis after down-regulation of RANKL expression in mouse bone.
results suggest that GABA(B)R2 protein levels are closely correlated with the partner subunit GABA(B)R1 protein levels in mouse brains during postnatal development in vivo
GABA(B) receptors are abundantly expressed on the vestibulospinal neurons of Deiters in mice. They contribute to the compensation of static vestibular reflexes following unilateral peripheral damage.
Our data suggest that association of GABAB(2) with GABAB(1) is essential for receptor localization in distal processes but not absolutely necessary for signaling. Functional GABAB receptors may exist in neurons that naturally lack GABAB(2) subunits.
heterodimeric GABAB(2) receptors are required for the normal regulation of emotional behaviour.
postsynaptic, and perhaps presynaptic, GABAB receptors may be expressed at GABAergic synapses between dendrites of periglomerular interneurons and projection neurons.
The presence of GABA(B)Rs in developing oligodendrocytes provides a new mechanism for neuronal-glial interactions during development and may offer a novel target for promoting remyelination following white matter injury.
Endogenous modulation of respiratory rhythm by GABA(B)-receptorsis mediated through activation of an inwardly rectifying potassium channel.conductance
Activation of GABA(B) receptor by either GABA or the selective agonist baclofen induces ERK(1/2) phosphorylation in cultured cerebellar granule neurons.
Postsynaptic GABA(B) receptors activated GIRK current and would further modulate the activity of FCs.
GABABR2 are expressed in the cerebellar cortex, supporting previous studies showing that inhibitory neurotransmission is highly patterned in the cerebellar cortex.
GABA B heteroreceptors regulating glutamate release are predominantly, but not exclusively composed of GABA B(1a) and GABA B(2) subunits
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
gamma-aminobutyric acid (GABA) B receptor, 2
, gamma-aminobutyric acid type B receptor subunit 2-like
, G protein-coupled receptor 51
, G-protein coupled receptor 51
, GABA-B R2 receptor
, GABA-B receptor 2
, gamma-aminobutyric acid type B receptor subunit 2
, GABA-B receptor, R2 subunit
, gamma-aminobutyric acid B receptor 2
, gamma-aminobutyric acid type B receptor, subunit 2
, ortholog of human G protein-coupled receptor 51 GPR51