Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Mouse (Murine) Antikörper:
anti-Rat (Rattus) Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal EGLN1 Primary Antibody für FACS, ICC - ABIN151071
Elvidge, Glenny, Appelhoff, Ratcliffe, Ragoussis, Gleadle: Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. in The Journal of biological chemistry 2006
Show all 66 Pubmed References
Human Polyclonal EGLN1 Primary Antibody für ICC, IF - ABIN250635
Mikhaylova, Ignacak, Barankiewicz, Harbaugh, Yi, Maxwell, Schneider, Van Geyte, Carmeliet, Revelo, Wyder, Greis, Meller, Czyzyk-Krzeska: The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. in Molecular and cellular biology 2008
Show all 24 Pubmed References
Human Polyclonal EGLN1 Primary Antibody für EM, FACS - ABIN151072
Baek, Mahon, Oh, Kelly, Krishnamachary, Pearson, Chan, Giaccia, Semenza: OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. in Molecular cell 2005
Show all 16 Pubmed References
Human Monoclonal EGLN1 Primary Antibody für IHC, IHC (p) - ABIN440716
Stolze, Tian, Appelhoff, Turley, Wykoff, Gleadle, Ratcliffe: Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. in The Journal of biological chemistry 2004
Show all 4 Pubmed References
Human Polyclonal EGLN1 Primary Antibody für ELISA, WB - ABIN565755
Aprelikova, Pandolfi, Tackett, Ferreira, Salnikow, Ward, Risinger, Barrett, Niederhuber: Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. in Cancer research 2009
oxygen via Phd2 has a decisive influence on the formation of the vascular network during vertebrate embryogenesis.
comparative analysis of phd1 (zeige EGLN2 Antikörper), 2, and 3 expression in Xenopus laevis
brain tissue protection and increased angiogenesis upon sub-acute ischemic stroke was completely absent in Phd2 knockout mice that were additionally deficient for both Hif1a (zeige HIF1A Antikörper) and Hif2a (zeige EPAS1 Antikörper)
expression of PHD2 in endothelial cells plays a critical role in preventing pulmonary arterial remodeling in mice
PHD-2 knockdown mesenchymal stromal cells overexpressed HIF-1alpha (zeige HIF1A Antikörper) and multiple angiogenic factors compared to control. Wounds treated with PHD-2 knockdown mesenchymal stromal cells healed at a significantly accelerated rate compared with wounds treated with shScramble mesenchymal stromal cells.
data identify the PHD2:HIF-2alpha:EPO axis as a so far unknown regulator of osteohematology by controlling bone homeostasis.
miR-21 contributes to the protection of delayed ischemic preconditioning against renal ischemia reperfusion injury in mice, which is at least in part mediated by targeting of PHD2 and subsequently up-regulating HIF-1alpha/VEGF pathway.
Phd2 is the dominant HIF-hydroxylase in neutrophils under normoxic conditions; intrinsic regulation of glycolysis and glycogen (zeige GYS1 Antikörper) stores is linked to the resolution of neutrophil-mediated inflammatory responses
Epo (zeige EPO Antikörper) transcription in brain pericytes was HIF-2 dependent and cocontrolled by PHD2 and PHD3 (zeige EGLN3 Antikörper), oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.
Notch ligand (zeige JAG2 Antikörper) genes Jag1 (zeige JAG1 Antikörper), Jag2 (zeige JAG2 Antikörper), and Dll1 (zeige DLL1 Antikörper) and target Hes1 became downregulated upon aging HIF-2alpha (zeige EPAS1 Antikörper) dependently.
Results identified a critical role of PHD2 for a reversible glycolytic reprogramming in macrophages with a direct impact on their function.
Results found that loss of endothelial PHD2 induced pulmonary arterial hypertension and vascular remodeling in a HIF-2-dependent fashion.
We genotyped 347 Tibetan individuals from varying altitudes for both the Tibetan-specific EGLN1 haplotype and 10 candidate SNPs in the EPAS1 haplotype and correlated their association with hemoglobin levels.
PHD2 is a direct binding partner of EGFR (zeige EGFR Antikörper) and show that PHD2 regulates EGFR (zeige EGFR Antikörper) stability as well as its subsequent signaling in breast carcinoma cells.
A mechanism of PHD2 regulation that involves the mTOR (zeige FRAP1 Antikörper) and PP2A (zeige PPP2R4 Antikörper) pathways.
These data unravel B55alpha (zeige PPP2R2A Antikörper) as a PHD2 substrate and highlight a role for PHD2-B55alpha (zeige PPP2R2A Antikörper) in the response to nutrient deprivation.
Genetic variants in HIF-1alpha (zeige HIF1A Antikörper) and PHD2 genes exist in Caucasians but do not appear to alter 30-day mortality in sepsis
The role of PHD-2 in breast cancer [review]
Sulfur mustard negatively affects hypoxia-stimulated HIF-1alpha (zeige HIF1A Antikörper) signaling in keratinocytes and fibroblasts and thus possibly contributes to delayed wound healing in SM-injured patients, which could be treated with PHD-2 inhibitors.
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
egl nine homolog 1 (C. elegans)
, egl nine homolog 1
, egl nine homolog 1-like
, egl nine homolog 2
, HIF-prolyl hydroxylase 2
, hypoxia-inducible factor prolyl hydroxylase 2
, prolyl hydroxylase domain-containing protein 2
, HIF prolyl hydroxylase 2
, egl nine-like protein 1
, zinc finger MYND domain-containing protein 6